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Total number of protein in "GO:0004713" GO term:  135

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
AATK AATK Q6ZMQ8 Serine/threonine-protein kinase LMTK1 chr17 GO:0004713 Not Cancer Driver No 108 0.079 912 75 0.082 0
ABL1_ENST00000318560 ABL1 P00519 Tyrosine-protein kinase ABL1 chr9 GO:0004713 Census, Compendium Yes 139 0.123 604 73 0.121 2
ABL2 ABL2 P42684 Tyrosine-protein kinase ABL2 chr1 GO:0004713 Census, Compendium Yes 171 0.145 641 70 0.109 0
ALK ALK Q9UM73 ALK tyrosine kinase receptor chr2 GO:0004713 Census, Compendium Yes 303 0.187 575 114 0.198 16
AXL AXL P30530 Tyrosine-protein kinase receptor UFO chr19 GO:0004713 Not Cancer Driver No 168 0.188 341 64 0.188 0
BAZ1B_ENST00000404251 BAZ1B Q9UIG0 Tyrosine-protein kinase BAZ1B chr7 GO:0004713 Not Cancer Driver No 153 0.103 840 87 0.104 0
BCR BCR P11274 Breakpoint cluster region protein chr22 GO:0004713 Census, Compendium Yes 146 0.115 603 69 0.114 0
BLK BLK P51451 Tyrosine-protein kinase Blk chr8 GO:0004713 Not Cancer Driver No 94 0.186 75 21 0.28 0
BMX_ENST00000342014 BMX P51813 Cytoplasmic tyrosine-protein kinase BMX chrX GO:0004713 Not Cancer Driver No 106 0.157 172 27 0.157 0
BTK_ENST00000308731 BTK Q06187 Tyrosine-protein kinase BTK chrX GO:0004713 Census, Compendium Yes 147 0.223 114 27 0.237 110
CAMKK2 CAMKK2 Q96RR4 Calcium/calmodulin-dependent protein kinase kinase 2 chr12 GO:0004713 Not Cancer Driver No 65 0.111 281 35 0.125 0
CLK1_ENST00000321356 CLK1 P49759 Dual specificity protein kinase CLK1 chr2 GO:0004713 Not Cancer Driver No 64 0.132 131 21 0.16 0
CLK2 CLK2 P49760 Dual specificity protein kinase CLK2 chr1 GO:0004713 Not Cancer Driver No 104 0.208 151 37 0.245 0
CLK3 CLK3 P49761 Dual specificity protein kinase CLK3 chr15 GO:0004713 Not Cancer Driver No 67 0.105 295 27 0.092 0
CLK4 CLK4 Q9HAZ1 Dual specificity protein kinase CLK4 chr5 GO:0004713 Not Cancer Driver No 60 0.125 102 14 0.137 0
CRIM1 CRIM1 Q9NZV1 Cysteine-rich motor neuron 1 protein chr2 GO:0004713 Not Cancer Driver No 133 0.128 35 4 0.114 0
CSF1R CSF1R P07333 Macrophage colony-stimulating factor 1 receptor chr5 GO:0004713 Census Yes 133 0.137 124 17 0.137 20
CSK_ENST00000439220 CSK P41240 Tyrosine-protein kinase CSK chr15 GO:0004713 Not Cancer Driver No 41 0.091 18 1 0.056 0
DDR1_ENST00000324771 DDR1 Q08345 Epithelial discoidin domain-containing receptor 1 chr6 GO:0004713 Not Cancer Driver No 123 0.135 253 49 0.194 0
DDR2 DDR2 Q16832 Discoidin domain-containing receptor 2 chr1 GO:0004713 Census Yes 192 0.225 118 34 0.288 7
DSTYK DSTYK Q6XUX3 Dual serine/threonine and tyrosine protein kinase chr1 GO:0004713 Not Cancer Driver No 112 0.121 112 4 0.036 2
DYRK1A_ENST00000644942 DYRK1A Q13627 Dual specificity tyrosine-phosphorylation-regulated kinase 1A chr21 GO:0004713 Not Cancer Driver No 135 0.177 447 73 0.163 0
DYRK1B_ENST00000323039 DYRK1B Q9Y463 Dual specificity tyrosine-phosphorylation-regulated kinase 1B chr19 GO:0004713 Not Cancer Driver No 77 0.122 319 38 0.119 2
DYRK2 DYRK2 Q92630 Dual specificity tyrosine-phosphorylation-regulated kinase 2 chr12 GO:0004713 Not Cancer Driver No 77 0.128 294 39 0.133 0
DYRK3 DYRK3 O43781 Dual specificity tyrosine-phosphorylation-regulated kinase 3 chr1 GO:0004713 Not Cancer Driver No 87 0.148 193 20 0.104 0
DYRK4_ENST00000010132 DYRK4 Q9NR20 Dual specificity tyrosine-phosphorylation-regulated kinase 4 chr12 GO:0004713 Not Cancer Driver No 111 0.213 178 33 0.185 0
EFEMP1_ENST00000355426 EFEMP1 Q12805 EGF-containing fibulin-like extracellular matrix protein 1 chr2 GO:0004713 Not Cancer Driver No 95 0.193 73 21 0.288 1
EFNA3 EFNA3 P52797 Ephrin-A3 chr1 GO:0004713 Not Cancer Driver No 24 0.101 31 11 0.355 0
EFNA4_ENST00000368409 EFNA4 P52798 Ephrin-A4 chr1 GO:0004713 Not Cancer Driver No 28 0.139 17 3 0.176 0
EFNB3 EFNB3 Q15768 Ephrin-B3 chr17 GO:0004713 Not Cancer Driver No 45 0.132 183 22 0.12 0
EGFR EGFR P00533 Epidermal growth factor receptor chr7 GO:0004713 Census, Compendium Yes 444 0.367 223 35 0.157 1
EIF2AK2_ENST00000395127 EIF2AK2 P19525 Interferon-induced, double-stranded RNA-activated protein kinase chr2 GO:0004713 Not Cancer Driver No 59 0.107 188 22 0.117 0
EPHA1 EPHA1 P21709 Ephrin type-A receptor 1 chr7 GO:0004713 Not Cancer Driver No 147 0.151 211 38 0.18 0
EPHA10 EPHA10 Q5JZY3 Ephrin type-A receptor 10 chr1 GO:0004713 Not Cancer Driver No 171 0.17 225 41 0.182 0
EPHA2 EPHA2 P29317 Ephrin type-A receptor 2 chr1 GO:0004713 Compendium Yes 171 0.175 187 39 0.209 3
EPHA3 EPHA3 P29320 Ephrin type-A receptor 3 chr3 GO:0004713 Census, Compendium Yes 346 0.352 74 28 0.378 0
EPHA4_ENST00000409938 EPHA4 P54764 Ephrin type-A receptor 4 chr2 GO:0004713 Not Cancer Driver No 182 0.185 140 24 0.171 0
EPHA5_ENST00000273854 EPHA5 P54756 Ephrin type-A receptor 5 chr4 GO:0004713 Not Cancer Driver No 341 0.329 83 39 0.47 0
EPHA7 EPHA7 Q15375 Ephrin type-A receptor 7 chr6 GO:0004713 Census, Compendium Yes 280 0.281 71 15 0.211 0
EPHA8 EPHA8 P29322 Ephrin type-A receptor 8 chr1 GO:0004713 Not Cancer Driver No 197 0.196 121 17 0.14 0
EPHB1 EPHB1 P54762 Ephrin type-B receptor 1 chr3 GO:0004713 Not Cancer Driver No 316 0.321 67 17 0.254 0
EPHB2 EPHB2 P29323 Ephrin type-B receptor 2 chr1 GO:0004713 Not Cancer Driver No 186 0.176 119 17 0.143 7
EPHB3 EPHB3 P54753 Ephrin type-B receptor 3 chr3 GO:0004713 Not Cancer Driver No 155 0.155 137 16 0.117 0
EPHB4 EPHB4 P54760 Ephrin type-B receptor 4 chr7 GO:0004713 Not Cancer Driver No 125 0.127 184 19 0.103 11
EPHB6_ENST00000422643 EPHB6 O15197 Ephrin type-B receptor 6 chr7 GO:0004713 Not Cancer Driver No 227 0.222 246 45 0.183 0
ERBB2 ERBB2 P04626 Receptor tyrosine-protein kinase erbB-2 chr17 GO:0004713 Census, Compendium Yes 275 0.219 314 41 0.131 1
ERBB3 ERBB3 P21860 Receptor tyrosine-protein kinase erbB-3 chr12 GO:0004713 Census, Compendium Yes 298 0.222 396 70 0.177 3
ERBB4 ERBB4 Q15303 Receptor tyrosine-protein kinase erbB-4 chr2 GO:0004713 Census, Compendium Yes 428 0.327 323 116 0.359 2
FER FER P16591 Tyrosine-protein kinase Fer chr5 GO:0004713 Not Cancer Driver No 114 0.139 145 21 0.145 0
FES FES P07332 Tyrosine-protein kinase Fes/Fps chr15 GO:0004713 Census Yes 103 0.125 245 34 0.139 0
FGFR1_ENST00000447712 FGFR1 P11362 Fibroblast growth factor receptor 1 chr8 GO:0004713 Census, Compendium Yes 152 0.185 230 43 0.187 74
FGFR2_ENST00000358487 FGFR2 P21802 Fibroblast growth factor receptor 2 chr10 GO:0004713 Census, Compendium Yes 238 0.29 228 44 0.193 72
FGFR3_ENST00000440486 FGFR3 P22607 Fibroblast growth factor receptor 3 chr4 GO:0004713 Census, Compendium Yes 173 0.215 241 26 0.108 37
FGFR4 FGFR4 P22455 Fibroblast growth factor receptor 4 chr5 GO:0004713 Census, Compendium Yes 113 0.141 162 28 0.173 0
FGFRL1_ENST00000264748 FGFRL1 Q8N441 Fibroblast growth factor receptor-like 1 chr4 GO:0004713 Not Cancer Driver No 74 0.147 278 34 0.122 0
FGR_ENST00000374004 FGR P09769 Tyrosine-protein kinase Fgr chr1 GO:0004713 Not Cancer Driver No 85 0.161 52 8 0.154 0
FLT1 FLT1 P17948 Vascular endothelial growth factor receptor 1 chr13 GO:0004713 Not Cancer Driver No 299 0.223 103 20 0.194 0
FLT3 FLT3 P36888 Receptor-type tyrosine-protein kinase FLT3 chr13 GO:0004713 Census, Compendium Yes 200 0.201 64 27 0.422 0
FLT4 FLT4 P35916 Vascular endothelial growth factor receptor 3 chr5 GO:0004713 Census, Compendium Yes 253 0.186 259 41 0.158 13
FRK FRK P42685 Tyrosine-protein kinase FRK chr6 GO:0004713 Not Cancer Driver No 87 0.172 18 2 0.111 0
FYN FYN P06241 Tyrosine-protein kinase Fyn chr6 GO:0004713 Not Cancer Driver No 92 0.171 70 13 0.186 0
HCK_ENST00000534862 HCK P08631 Tyrosine-protein kinase HCK chr20 GO:0004713 Not Cancer Driver No 112 0.213 124 25 0.202 0
HIPK1_ENST00000426820 HIPK1 Q86Z02 Homeodomain-interacting protein kinase 1 chr1 GO:0004713 Not Cancer Driver No 158 0.131 565 89 0.158 0
HIPK2 HIPK2 Q9H2X6 Homeodomain-interacting protein kinase 2 chr7 GO:0004713 Not Cancer Driver No 154 0.129 686 96 0.14 0
HIPK3 HIPK3 Q9H422 Homeodomain-interacting protein kinase 3 chr11 GO:0004713 Not Cancer Driver No 128 0.105 559 51 0.091 0
HIPK4 HIPK4 Q8NE63 Homeodomain-interacting protein kinase 4 chr19 GO:0004713 Not Cancer Driver No 87 0.141 258 23 0.089 0
IGF1R IGF1R P08069 Insulin-like growth factor 1 receptor chr15 GO:0004713 Not Cancer Driver No 183 0.134 265 37 0.14 6
IGF2R IGF2R P11717 Cation-independent mannose-6-phosphate receptor chr6 GO:0004713 Not Cancer Driver No 318 0.128 255 20 0.078 0
INSR INSR P06213 Insulin receptor chr19 GO:0004713 Not Cancer Driver No 190 0.137 280 57 0.204 64
INSRR INSRR P14616 Insulin receptor-related protein chr1 GO:0004713 Not Cancer Driver No 262 0.202 228 37 0.162 0
ITK ITK Q08881 Tyrosine-protein kinase ITK/TSK chr5 GO:0004713 Census Yes 139 0.224 43 10 0.233 1
JAK1 JAK1 P23458 Tyrosine-protein kinase JAK1 chr1 GO:0004713 Census, Compendium Yes 147 0.127 120 7 0.058 2
JAK2 JAK2 O60674 Tyrosine-protein kinase JAK2 chr9 GO:0004713 Census, Compendium Yes 136 0.12 59 5 0.085 5
JAK3 JAK3 P52333 Tyrosine-protein kinase JAK3 chr19 GO:0004713 Census, Compendium Yes 167 0.149 63 10 0.159 7
KDR KDR P35968 Vascular endothelial growth factor receptor 2 chr4 GO:0004713 Census, Compendium Yes 357 0.263 275 55 0.2 2
KIT KIT P10721 Mast/stem cell growth factor receptor Kit chr4 GO:0004713 Census, Compendium Yes 226 0.232 83 33 0.398 21
LCK LCK P06239 Tyrosine-protein kinase Lck chr1 GO:0004713 Census Yes 86 0.169 94 13 0.138 1
LTK LTK P29376 Leukocyte tyrosine kinase receptor chr15 GO:0004713 Not Cancer Driver No 103 0.119 301 30 0.1 0
LYN LYN P07948 Tyrosine-protein kinase Lyn chr8 GO:0004713 Census Yes 95 0.186 84 12 0.143 0
MAP2K1 MAP2K1 Q02750 Dual specificity mitogen-activated protein kinase kinase 1 chr15 GO:0004713 Census, Compendium Yes 94 0.239 96 24 0.25 6
MAP2K2 MAP2K2 P36507 Dual specificity mitogen-activated protein kinase kinase 2 chr19 GO:0004713 Census Yes 58 0.145 105 14 0.133 4
MAP2K3 MAP2K3 P46734 Dual specificity mitogen-activated protein kinase kinase 3 chr17 GO:0004713 Not Cancer Driver No 104 0.3 75 27 0.36 0
MAP2K4_ENST00000353533 MAP2K4 P45985 Dual specificity mitogen-activated protein kinase kinase 4 chr17 GO:0004713 Census, Compendium Yes 89 0.223 137 28 0.204 0
MAP2K5 MAP2K5 Q13163 Dual specificity mitogen-activated protein kinase kinase 5 chr15 GO:0004713 Not Cancer Driver No 40 0.089 85 10 0.118 0
MAP2K6 MAP2K6 P52564 Dual specificity mitogen-activated protein kinase kinase 6 chr17 GO:0004713 Not Cancer Driver No 48 0.144 55 11 0.2 0
MAP2K7_ENST00000397979 MAP2K7 O14733 Dual specificity mitogen-activated protein kinase kinase 7 chr19 GO:0004713 Compendium Yes 89 0.212 144 20 0.139 0
MATK_ENST00000310132 MATK P42679 Megakaryocyte-associated tyrosine-protein kinase chr19 GO:0004713 Not Cancer Driver No 94 0.185 146 27 0.185 0
MELK MELK Q14680 Maternal embryonic leucine zipper kinase chr9 GO:0004713 Not Cancer Driver No 76 0.117 162 24 0.148 0
MET_ENST00000397752 MET P08581 Hepatocyte growth factor receptor chr7 GO:0004713 Census, Compendium Yes 226 0.163 62 15 0.242 19
MST1R MST1R Q04912 Macrophage-stimulating protein receptor chr3 GO:0004713 Not Cancer Driver No 178 0.127 182 27 0.148 1
MUSK MUSK O15146 Muscle, skeletal receptor tyrosine-protein kinase chr9 GO:0004713 Not Cancer Driver No 188 0.216 35 7 0.2 7
NEK1_ENST00000439128 NEK1 Q96PY6 Serine/threonine-protein kinase Nek1 chr4 GO:0004713 Not Cancer Driver No 131 0.104 879 98 0.111 3
NRP1 NRP1 O14786 Neuropilin-1 chr10 GO:0004713 Compendium Yes 146 0.158 211 31 0.147 0
NRP2 NRP2 O60462 Neuropilin-2 chr2 GO:0004713 Not Cancer Driver No 161 0.173 207 45 0.217 0
NTRK1 NTRK1 P04629 High affinity nerve growth factor receptor chr1 GO:0004713 Census, Compendium Yes 168 0.211 57 8 0.14 25
NTRK2_ENST00000323115 NTRK2 Q16620 BDNF/NT-3 growth factors receptor chr9 GO:0004713 Not Cancer Driver No 155 0.189 117 18 0.154 1
NTRK3_ENST00000629765 NTRK3 Q16288 NT-3 growth factor receptor chr15 GO:0004713 Census, Compendium Yes 249 0.297 57 21 0.368 0
PBK_ENST00000301905 PBK Q96KB5 Lymphokine-activated killer T-cell-originated protein kinase chr8 GO:0004713 Not Cancer Driver No 23 0.071 92 6 0.065 0
PDGFRA PDGFRA P16234 Platelet-derived growth factor receptor alpha chr4 GO:0004713 Census, Compendium Yes 290 0.266 173 45 0.26 2
PDGFRB PDGFRB P09619 Platelet-derived growth factor receptor beta chr5 GO:0004713 Census, Compendium Yes 164 0.148 231 44 0.19 7
PDGFRL PDGFRL Q15198 Platelet-derived growth factor receptor-like protein chr8 GO:0004713 Not Cancer Driver No 46 0.123 67 12 0.179 1
PEAK1_ENST00000312493 PEAK1 Q9H792 Inactive tyrosine-protein kinase PEAK1 chr15 GO:0004713 Not Cancer Driver No 222 0.127 1232 150 0.122 0
PKDCC PKDCC Q504Y2 Extracellular tyrosine-protein kinase PKDCC chr2 GO:0004713 Not Cancer Driver No 36 0.073 124 0 0.0 0
PRKCD_ENST00000330452 PRKCD Q05655 Protein kinase C delta type chr3 GO:0004713 Compendium Yes 79 0.117 43 9 0.209 0
PTK2B_ENST00000346049 PTK2B Q14289 Protein-tyrosine kinase 2-beta chr8 GO:0004713 Not Cancer Driver No 161 0.16 261 37 0.142 0
PTK2_ENST00000522684 PTK2 Q05397 Focal adhesion kinase 1 chr8 GO:0004713 Not Cancer Driver No 134 0.127 425 55 0.129 0
PTK6 PTK6 Q13882 Protein-tyrosine kinase 6 chr20 GO:0004713 Census Yes 42 0.093 12 0 0.0 0
RET RET P07949 Proto-oncogene tyrosine-protein kinase receptor Ret chr10 GO:0004713 Census, Compendium Yes 208 0.187 105 12 0.114 139
RIPK2 RIPK2 O43353 Receptor-interacting serine/threonine-protein kinase 2 chr8 GO:0004713 Not Cancer Driver No 63 0.117 143 20 0.14 0
ROS1 ROS1 P08922 Proto-oncogene tyrosine-protein kinase ROS chr6 GO:0004713 Census Yes 498 0.212 191 55 0.288 0
RYK_ENST00000623711 RYK P34925 Tyrosine-protein kinase RYK chr3 GO:0004713 Not Cancer Driver No 55 0.091 85 4 0.047 0
SCYL1 SCYL1 Q96KG9 N-terminal kinase-like protein chr11 GO:0004713 Not Cancer Driver No 85 0.105 312 32 0.103 0
SLA_ENST00000338087 SLA Q13239 Src-like-adapter chr8 GO:0004713 Not Cancer Driver No 59 0.214 51 11 0.216 0
SRC_ENST00000358208 SRC P12931 Proto-oncogene tyrosine-protein kinase Src chr20 GO:0004713 Census Yes 53 0.099 130 11 0.085 1
SRMS SRMS Q9H3Y6 Tyrosine-protein kinase Srms chr20 GO:0004713 Not Cancer Driver No 77 0.158 48 11 0.229 0
STK16_ENST00000396738 STK16 O75716 Serine/threonine-protein kinase 16 chr2 GO:0004713 Not Cancer Driver No 42 0.138 48 3 0.062 0
STYK1 STYK1 Q6J9G0 Tyrosine-protein kinase STYK1 chr12 GO:0004713 Not Cancer Driver No 83 0.197 35 10 0.286 0
SYK_ENST00000375746 SYK P43405 Tyrosine-protein kinase SYK chr9 GO:0004713 Census Yes 96 0.151 131 27 0.206 5
TEC TEC P42680 Tyrosine-protein kinase Tec chr4 GO:0004713 Census, Compendium Yes 91 0.144 57 15 0.263 0
TEK TEK Q02763 Angiopoietin-1 receptor chr9 GO:0004713 Not Cancer Driver No 219 0.195 126 22 0.175 10
TESK1_ENST00000336395 TESK1 Q15569 Dual specificity testis-specific protein kinase 1 chr9 GO:0004713 Not Cancer Driver No 63 0.101 339 35 0.103 0
TESK2 TESK2 Q96S53 Dual specificity testis-specific protein kinase 2 chr1 GO:0004713 Not Cancer Driver No 77 0.135 242 43 0.178 0
TNK1 TNK1 Q13470 Non-receptor tyrosine-protein kinase TNK1 chr17 GO:0004713 Not Cancer Driver No 51 0.077 298 24 0.081 0
TNK2_ENST00000333602 TNK2 Q07912 Activated CDC42 kinase 1 chr3 GO:0004713 Not Cancer Driver No 137 0.132 593 81 0.137 0
TTBK1 TTBK1 Q5TCY1 Tau-tubulin kinase 1 chr6 GO:0004713 Not Cancer Driver No 193 0.146 1045 154 0.147 0
TTK TTK P33981 Dual specificity protein kinase TTK chr6 GO:0004713 Not Cancer Driver No 136 0.159 352 46 0.131 0
TTN_ENST00000615779 TTN Q8WZ42 Titin chr2 GO:0004713 Not Cancer Driver No 7917 0.23 12926 2861 0.221 10
TWF1_ENST00000395510 TWF1 Q12792 Twinfilin-1 chr12 GO:0004713 Not Cancer Driver No 50 0.143 52 3 0.058 0
TXK TXK P42681 Tyrosine-protein kinase TXK chr4 GO:0004713 Not Cancer Driver No 87 0.165 61 9 0.148 0
TYK2 TYK2 P29597 Non-receptor tyrosine-protein kinase TYK2 chr19 GO:0004713 Not Cancer Driver No 148 0.125 213 29 0.136 0
TYRO3 TYRO3 Q06418 Tyrosine-protein kinase receptor TYRO3 chr15 GO:0004713 Not Cancer Driver No 119 0.134 197 17 0.086 0
WEE1 WEE1 P30291 Wee1-like protein kinase chr11 GO:0004713 Not Cancer Driver No 60 0.093 399 27 0.068 0
WEE2 WEE2 P0C1S8 Wee1-like protein kinase 2 chr7 GO:0004713 Not Cancer Driver No 104 0.183 345 65 0.188 1
YES1_ENST00000314574 YES1 P07947 Tyrosine-protein kinase Yes chr18 GO:0004713 Not Cancer Driver No 65 0.12 62 10 0.161 0
ZAP70 ZAP70 P43403 Tyrosine-protein kinase ZAP-70 chr2 GO:0004713 Not Cancer Driver No 126 0.204 117 17 0.145 8