Total number of protein in "GO:0004536" GO term: 50
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| APEX1_ENST00000555414 | APEX1 | P27695 | DNA-(apurinic or apyrimidinic site) endonuclease | chr14 | GO:0004536 | Not Cancer Driver | No | 34 | 0.107 | 103 | 14 | 0.136 | 0 |
| APEX2 | APEX2 | Q9UBZ4 | DNA-(apurinic or apyrimidinic site) endonuclease 2 | chrX | GO:0004536 | Not Cancer Driver | No | 66 | 0.127 | 148 | 14 | 0.095 | 0 |
| APTX_ENST00000379819 | APTX | Q7Z2E3 | Aprataxin | chr9 | GO:0004536 | Not Cancer Driver | No | 36 | 0.101 | 101 | 6 | 0.059 | 9 |
| DCLRE1A | DCLRE1A | Q6PJP8 | DNA cross-link repair 1A protein | chr10 | GO:0004536 | Not Cancer Driver | No | 92 | 0.088 | 514 | 45 | 0.088 | 0 |
| DCLRE1B | DCLRE1B | Q9H816 | 5' exonuclease Apollo | chr1 | GO:0004536 | Not Cancer Driver | No | 65 | 0.122 | 127 | 17 | 0.134 | 0 |
| DCLRE1C | DCLRE1C | Q96SD1 | Protein artemis | chr10 | GO:0004536 | Not Cancer Driver | No | 76 | 0.11 | 277 | 26 | 0.094 | 3 |
| DFFB_ENST00000378209 | DFFB | O76075 | DNA fragmentation factor subunit beta | chr1 | GO:0004536 | Not Cancer Driver | No | 37 | 0.109 | 27 | 1 | 0.037 | 0 |
| DICER1 | DICER1 | Q9UPY3 | Endoribonuclease Dicer | chr14 | GO:0004536 | Census, Compendium | Yes | 264 | 0.137 | 362 | 45 | 0.124 | 4 |
| DNA2 | DNA2 | P51530 | DNA replication ATP-dependent helicase/nuclease DNA2 | chr10 | GO:0004536 | Not Cancer Driver | No | 120 | 0.113 | 52 | 8 | 0.154 | 3 |
| DNASE1L1 | DNASE1L1 | P49184 | Deoxyribonuclease-1-like 1 | chrX | GO:0004536 | Not Cancer Driver | No | 30 | 0.099 | 0 | 0 | 0.0 | 0 |
| DNASE1L2_ENST00000567494 | DNASE1L2 | Q92874 | Deoxyribonuclease-1-like 2 | chr16 | GO:0004536 | Not Cancer Driver | No | 23 | 0.077 | 15 | 1 | 0.067 | 0 |
| DNASE1L3 | DNASE1L3 | Q13609 | Deoxyribonuclease gamma | chr3 | GO:0004536 | Not Cancer Driver | No | 43 | 0.141 | 15 | 4 | 0.267 | 0 |
| DNASE1_ENST00000246949 | DNASE1 | P24855 | Deoxyribonuclease-1 | chr16 | GO:0004536 | Not Cancer Driver | No | 24 | 0.085 | 0 | 0 | 0.0 | 0 |
| DNASE2 | DNASE2 | O00115 | Deoxyribonuclease-2-alpha | chr19 | GO:0004536 | Not Cancer Driver | No | 46 | 0.128 | 48 | 7 | 0.146 | 0 |
| DNASE2B | DNASE2B | Q8WZ79 | Deoxyribonuclease-2-beta | chr1 | GO:0004536 | Not Cancer Driver | No | 53 | 0.147 | 14 | 1 | 0.071 | 0 |
| ENDOG | ENDOG | Q14249 | Endonuclease G, mitochondrial | chr9 | GO:0004536 | Not Cancer Driver | No | 11 | 0.037 | 61 | 1 | 0.016 | 0 |
| ENDOV | ENDOV | Q8N8Q3 | Endonuclease V | chr17 | GO:0004536 | Not Cancer Driver | No | 28 | 0.099 | 43 | 3 | 0.07 | 0 |
| ERCC1_ENST00000589165 | ERCC1 | P07992 | DNA excision repair protein ERCC-1 | chr19 | GO:0004536 | Not Cancer Driver | No | 42 | 0.141 | 105 | 14 | 0.133 | 1 |
| ERCC4 | ERCC4 | Q92889 | DNA repair endonuclease XPF | chr16 | GO:0004536 | Census | Yes | 120 | 0.131 | 225 | 27 | 0.12 | 15 |
| EXD2 | EXD2 | Q9NVH0 | Exonuclease 3'-5' domain-containing protein 2 | chr14 | GO:0004536 | Not Cancer Driver | No | 58 | 0.093 | 176 | 15 | 0.085 | 0 |
| EXO1_ENST00000348581 | EXO1 | Q9UQ84 | Exonuclease 1 | chr1 | GO:0004536 | Not Cancer Driver | No | 123 | 0.145 | 472 | 76 | 0.161 | 0 |
| EXO5_ENST00000358527 | EXO5 | Q9H790 | Exonuclease V | chr1 | GO:0004536 | Not Cancer Driver | No | 39 | 0.105 | 36 | 3 | 0.083 | 0 |
| EXOG | EXOG | Q9Y2C4 | Nuclease EXOG, mitochondrial | chr3 | GO:0004536 | Not Cancer Driver | No | 42 | 0.114 | 52 | 1 | 0.019 | 0 |
| FAN1 | FAN1 | Q9Y2M0 | Fanconi-associated nuclease 1 | chr15 | GO:0004536 | Not Cancer Driver | No | 124 | 0.122 | 212 | 27 | 0.127 | 4 |
| FEN1 | FEN1 | P39748 | Flap endonuclease 1 | chr11 | GO:0004536 | Census | Yes | 35 | 0.092 | 111 | 11 | 0.099 | 0 |
| GEN1_ENST00000381254 | GEN1 | Q17RS7 | Flap endonuclease GEN homolog 1 | chr2 | GO:0004536 | Not Cancer Driver | No | 109 | 0.12 | 339 | 52 | 0.153 | 0 |
| ISG20 | ISG20 | Q96AZ6 | Interferon-stimulated gene 20 kDa protein | chr15 | GO:0004536 | Not Cancer Driver | No | 20 | 0.11 | 6 | 0 | 0.0 | 0 |
| MAP1S | MAP1S | Q66K74 | Microtubule-associated protein 1S | chr19 | GO:0004536 | Not Cancer Driver | No | 118 | 0.111 | 527 | 48 | 0.091 | 0 |
| MEIOB_ENST00000397344 | MEIOB | Q8N635 | Meiosis-specific with OB domain-containing protein | chr16 | GO:0004536 | Not Cancer Driver | No | 37 | 0.084 | 21 | 2 | 0.095 | 1 |
| MGME1 | MGME1 | Q9BQP7 | Mitochondrial genome maintenance exonuclease 1 | chr20 | GO:0004536 | Not Cancer Driver | No | 33 | 0.096 | 95 | 7 | 0.074 | 1 |
| MRE11 | MRE11 | P49959 | Double-strand break repair protein MRE11 | chr11 | GO:0004536 | Not Cancer Driver | No | 84 | 0.119 | 292 | 35 | 0.12 | 1 |
| MUS81 | MUS81 | Q96NY9 | Crossover junction endonuclease MUS81 | chr11 | GO:0004536 | Not Cancer Driver | No | 67 | 0.122 | 232 | 38 | 0.164 | 0 |
| NME1_ENST00000393196 | NME1 | P15531 | Nucleoside diphosphate kinase A | chr17 | GO:0004536 | Not Cancer Driver | No | 11 | 0.072 | 10 | 0 | 0.0 | 0 |
| PLD3_ENST00000409735 | PLD3 | Q8IV08 | 5'-3' exonuclease PLD3 | chr19 | GO:0004536 | Not Cancer Driver | No | 70 | 0.143 | 62 | 7 | 0.113 | 0 |
| PLD4_ENST00000392593 | PLD4 | Q96BZ4 | 5'-3' exonuclease PLD4 | chr14 | GO:0004536 | Not Cancer Driver | No | 46 | 0.091 | 76 | 10 | 0.132 | 0 |
| POLE | POLE | Q07864 | DNA polymerase epsilon catalytic subunit A | chr12 | GO:0004536 | Census, Compendium | Yes | 409 | 0.179 | 239 | 44 | 0.184 | 3 |
| RAD1 | RAD1 | O60671 | Cell cycle checkpoint protein RAD1 | chr5 | GO:0004536 | Not Cancer Driver | No | 29 | 0.103 | 4 | 1 | 0.25 | 0 |
| RAD50 | RAD50 | Q92878 | DNA repair protein RAD50 | chr5 | GO:0004536 | Not Cancer Driver | No | 157 | 0.12 | 730 | 84 | 0.115 | 0 |
| RAD51C | RAD51C | O43502 | DNA repair protein RAD51 homolog 3 | chr17 | GO:0004536 | Not Cancer Driver | No | 47 | 0.125 | 18 | 2 | 0.111 | 6 |
| RAD9A | RAD9A | Q99638 | Cell cycle checkpoint control protein RAD9A | chr11 | GO:0004536 | Not Cancer Driver | No | 34 | 0.087 | 135 | 7 | 0.052 | 0 |
| RAG1 | RAG1 | P15918 | V(D)J recombination-activating protein 1 | chr11 | GO:0004536 | Not Cancer Driver | No | 204 | 0.196 | 208 | 43 | 0.207 | 36 |
| RBBP8_ENST00000327155 | RBBP8 | Q99708 | DNA endonuclease RBBP8 | chr18 | GO:0004536 | Not Cancer Driver | No | 99 | 0.11 | 750 | 76 | 0.101 | 1 |
| SETMAR | SETMAR | Q53H47 | Histone-lysine N-methyltransferase SETMAR | chr3 | GO:0004536 | Not Cancer Driver | No | 62 | 0.091 | 154 | 12 | 0.078 | 0 |
| SLX1B | SLX1B | Q9BQ83 | Structure-specific endonuclease subunit SLX1 | chr16 | GO:0004536 | Not Cancer Driver | No | 3 | 0.011 | 80 | 1 | 0.013 | 0 |
| TEFM | TEFM | Q96QE5 | Transcription elongation factor, mitochondrial | chr17 | GO:0004536 | Not Cancer Driver | No | 37 | 0.103 | 26 | 5 | 0.192 | 0 |
| TREX1_ENST00000625293 | TREX1 | Q9NSU2 | Three-prime repair exonuclease 1 | chr3 | GO:0004536 | Not Cancer Driver | No | 26 | 0.083 | 98 | 10 | 0.102 | 18 |
| TREX2_ENST00000370231 | TREX2 | Q9BQ50 | Three prime repair exonuclease 2 | chrX | GO:0004536 | Not Cancer Driver | No | 33 | 0.14 | 23 | 6 | 0.261 | 0 |
| XRCC1 | XRCC1 | P18887 | DNA repair protein XRCC1 | chr19 | GO:0004536 | Not Cancer Driver | No | 85 | 0.134 | 426 | 53 | 0.124 | 1 |
| XRCC3_ENST00000352127 | XRCC3 | O43542 | DNA repair protein XRCC3 | chr14 | GO:0004536 | Not Cancer Driver | No | 24 | 0.069 | 35 | 2 | 0.057 | 1 |
| ZGRF1 | ZGRF1 | Q86YA3 | Protein ZGRF1 | chr4 | GO:0004536 | Not Cancer Driver | No | 216 | 0.103 | 881 | 95 | 0.108 | 0 |