Total number of protein in "GO:0004527" GO term: 62
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AEN | AEN | Q8WTP8 | Apoptosis-enhancing nuclease | chr15 | GO:0004527 | Not Cancer Driver | No | 39 | 0.12 | 183 | 21 | 0.115 | 0 |
| APEX1_ENST00000555414 | APEX1 | P27695 | DNA-(apurinic or apyrimidinic site) endonuclease | chr14 | GO:0004527 | Not Cancer Driver | No | 34 | 0.107 | 103 | 14 | 0.136 | 0 |
| APEX2 | APEX2 | Q9UBZ4 | DNA-(apurinic or apyrimidinic site) endonuclease 2 | chrX | GO:0004527 | Not Cancer Driver | No | 66 | 0.127 | 148 | 14 | 0.095 | 0 |
| APTX_ENST00000379819 | APTX | Q7Z2E3 | Aprataxin | chr9 | GO:0004527 | Not Cancer Driver | No | 36 | 0.101 | 101 | 6 | 0.059 | 9 |
| CNOT1 | CNOT1 | A5YKK6 | CCR4-NOT transcription complex subunit 1 | chr16 | GO:0004527 | Not Cancer Driver | No | 346 | 0.146 | 464 | 56 | 0.121 | 12 |
| CNOT2 | CNOT2 | Q9NZN8 | CCR4-NOT transcription complex subunit 2 | chr12 | GO:0004527 | Not Cancer Driver | No | 84 | 0.156 | 354 | 66 | 0.186 | 0 |
| CNOT6L | CNOT6L | Q96LI5 | CCR4-NOT transcription complex subunit 6-like | chr4 | GO:0004527 | Not Cancer Driver | No | 58 | 0.105 | 37 | 3 | 0.081 | 0 |
| CNOT6_ENST00000261951 | CNOT6 | Q9ULM6 | CCR4-NOT transcription complex subunit 6 | chr5 | GO:0004527 | Not Cancer Driver | No | 65 | 0.117 | 66 | 4 | 0.061 | 0 |
| CNOT7 | CNOT7 | Q9UIV1 | CCR4-NOT transcription complex subunit 7 | chr8 | GO:0004527 | Not Cancer Driver | No | 31 | 0.109 | 21 | 1 | 0.048 | 0 |
| CNOT8 | CNOT8 | Q9UFF9 | CCR4-NOT transcription complex subunit 8 | chr5 | GO:0004527 | Not Cancer Driver | No | 30 | 0.103 | 6 | 0 | 0.0 | 0 |
| CPSF3 | CPSF3 | Q9UKF6 | Cleavage and polyadenylation specificity factor subunit 3 | chr2 | GO:0004527 | Not Cancer Driver | No | 78 | 0.114 | 56 | 9 | 0.161 | 0 |
| DCLRE1A | DCLRE1A | Q6PJP8 | DNA cross-link repair 1A protein | chr10 | GO:0004527 | Not Cancer Driver | No | 92 | 0.088 | 514 | 45 | 0.088 | 0 |
| DCLRE1B | DCLRE1B | Q9H816 | 5' exonuclease Apollo | chr1 | GO:0004527 | Not Cancer Driver | No | 65 | 0.122 | 127 | 17 | 0.134 | 0 |
| DCLRE1C | DCLRE1C | Q96SD1 | Protein artemis | chr10 | GO:0004527 | Not Cancer Driver | No | 76 | 0.11 | 277 | 26 | 0.094 | 3 |
| DCP2 | DCP2 | Q8IU60 | m7GpppN-mRNA hydrolase | chr5 | GO:0004527 | Not Cancer Driver | No | 57 | 0.136 | 167 | 24 | 0.144 | 0 |
| DCPS | DCPS | Q96C86 | m7GpppX diphosphatase | chr11 | GO:0004527 | Not Cancer Driver | No | 48 | 0.142 | 53 | 6 | 0.113 | 1 |
| DDX1 | DDX1 | Q92499 | ATP-dependent RNA helicase DDX1 | chr2 | GO:0004527 | Not Cancer Driver | No | 82 | 0.111 | 91 | 15 | 0.165 | 0 |
| ENPP1 | ENPP1 | P22413 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 | chr6 | GO:0004527 | Not Cancer Driver | No | 148 | 0.16 | 101 | 5 | 0.05 | 33 |
| ENPP2_ENST00000075322 | ENPP2 | Q13822 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 | chr8 | GO:0004527 | Not Cancer Driver | No | 168 | 0.195 | 81 | 16 | 0.198 | 0 |
| ENPP3_ENST00000357639 | ENPP3 | O14638 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 3 | chr6 | GO:0004527 | Not Cancer Driver | No | 146 | 0.167 | 57 | 12 | 0.211 | 0 |
| EXD2 | EXD2 | Q9NVH0 | Exonuclease 3'-5' domain-containing protein 2 | chr14 | GO:0004527 | Not Cancer Driver | No | 58 | 0.093 | 176 | 15 | 0.085 | 0 |
| EXO1_ENST00000348581 | EXO1 | Q9UQ84 | Exonuclease 1 | chr1 | GO:0004527 | Not Cancer Driver | No | 123 | 0.145 | 472 | 76 | 0.161 | 0 |
| EXO5_ENST00000358527 | EXO5 | Q9H790 | Exonuclease V | chr1 | GO:0004527 | Not Cancer Driver | No | 39 | 0.105 | 36 | 3 | 0.083 | 0 |
| EXOSC1 | EXOSC1 | Q9Y3B2 | Exosome complex component CSL4 | chr10 | GO:0004527 | Not Cancer Driver | No | 14 | 0.072 | 14 | 2 | 0.143 | 1 |
| EXOSC10 | EXOSC10 | Q01780 | Exosome component 10 | chr1 | GO:0004527 | Not Cancer Driver | No | 87 | 0.098 | 375 | 35 | 0.093 | 0 |
| EXOSC2 | EXOSC2 | Q13868 | Exosome complex component RRP4 | chr9 | GO:0004527 | Not Cancer Driver | No | 21 | 0.072 | 47 | 6 | 0.128 | 2 |
| EXOSC3 | EXOSC3 | Q9NQT5 | Exosome complex component RRP40 | chr9 | GO:0004527 | Not Cancer Driver | No | 18 | 0.065 | 54 | 2 | 0.037 | 4 |
| EXOSC4 | EXOSC4 | Q9NPD3 | Exosome complex component RRP41 | chr8 | GO:0004527 | Not Cancer Driver | No | 34 | 0.139 | 23 | 0 | 0.0 | 0 |
| EXOSC5 | EXOSC5 | Q9NQT4 | Exosome complex component RRP46 | chr19 | GO:0004527 | Not Cancer Driver | No | 43 | 0.183 | 31 | 3 | 0.097 | 0 |
| EXOSC6 | EXOSC6 | Q5RKV6 | Exosome complex component MTR3 | chr16 | GO:0004527 | Not Cancer Driver | No | 3 | 0.011 | 102 | 0 | 0.0 | 0 |
| EXOSC7 | EXOSC7 | Q15024 | Exosome complex component RRP42 | chr3 | GO:0004527 | Not Cancer Driver | No | 41 | 0.141 | 8 | 1 | 0.125 | 0 |
| EXOSC8 | EXOSC8 | Q96B26 | Exosome complex component RRP43 | chr13 | GO:0004527 | Not Cancer Driver | No | 20 | 0.072 | 28 | 1 | 0.036 | 2 |
| EXOSC9_ENST00000243498 | EXOSC9 | Q06265 | Exosome complex component RRP45 | chr4 | GO:0004527 | Not Cancer Driver | No | 58 | 0.132 | 154 | 18 | 0.117 | 1 |
| FAN1 | FAN1 | Q9Y2M0 | Fanconi-associated nuclease 1 | chr15 | GO:0004527 | Not Cancer Driver | No | 124 | 0.122 | 212 | 27 | 0.127 | 4 |
| FEN1 | FEN1 | P39748 | Flap endonuclease 1 | chr11 | GO:0004527 | Census | Yes | 35 | 0.092 | 111 | 11 | 0.099 | 0 |
| ISG20 | ISG20 | Q96AZ6 | Interferon-stimulated gene 20 kDa protein | chr15 | GO:0004527 | Not Cancer Driver | No | 20 | 0.11 | 6 | 0 | 0.0 | 0 |
| ISG20L2 | ISG20L2 | Q9H9L3 | Interferon-stimulated 20 kDa exonuclease-like 2 | chr1 | GO:0004527 | Not Cancer Driver | No | 46 | 0.13 | 232 | 33 | 0.142 | 0 |
| MEIOB_ENST00000397344 | MEIOB | Q8N635 | Meiosis-specific with OB domain-containing protein | chr16 | GO:0004527 | Not Cancer Driver | No | 37 | 0.084 | 21 | 2 | 0.095 | 1 |
| MGME1 | MGME1 | Q9BQP7 | Mitochondrial genome maintenance exonuclease 1 | chr20 | GO:0004527 | Not Cancer Driver | No | 33 | 0.096 | 95 | 7 | 0.074 | 1 |
| NOCT | NOCT | Q9UK39 | Nocturnin | chr4 | GO:0004527 | Not Cancer Driver | No | 33 | 0.077 | 89 | 3 | 0.034 | 0 |
| PAN2_ENST00000548043 | PAN2 | Q504Q3 | PAN2-PAN3 deadenylation complex catalytic subunit PAN2 | chr12 | GO:0004527 | Not Cancer Driver | No | 139 | 0.116 | 78 | 10 | 0.128 | 0 |
| PAN3 | PAN3 | Q58A45 | PAN2-PAN3 deadenylation complex subunit PAN3 | chr13 | GO:0004527 | Not Cancer Driver | No | 104 | 0.117 | 323 | 35 | 0.108 | 0 |
| PARN | PARN | O95453 | Poly(A)-specific ribonuclease PARN | chr16 | GO:0004527 | Not Cancer Driver | No | 71 | 0.111 | 197 | 22 | 0.112 | 2 |
| PDE12 | PDE12 | Q6L8Q7 | 2',5'-phosphodiesterase 12 | chr3 | GO:0004527 | Not Cancer Driver | No | 59 | 0.097 | 129 | 8 | 0.062 | 0 |
| PLD3_ENST00000409735 | PLD3 | Q8IV08 | 5'-3' exonuclease PLD3 | chr19 | GO:0004527 | Not Cancer Driver | No | 70 | 0.143 | 62 | 7 | 0.113 | 0 |
| PLD4_ENST00000392593 | PLD4 | Q96BZ4 | 5'-3' exonuclease PLD4 | chr14 | GO:0004527 | Not Cancer Driver | No | 46 | 0.091 | 76 | 10 | 0.132 | 0 |
| PNLDC1_ENST00000610273 | PNLDC1 | Q8NA58 | Poly(A)-specific ribonuclease PNLDC1 | chr6 | GO:0004527 | Not Cancer Driver | No | 105 | 0.202 | 6 | 0 | 0.0 | 1 |
| POLE | POLE | Q07864 | DNA polymerase epsilon catalytic subunit A | chr12 | GO:0004527 | Census, Compendium | Yes | 409 | 0.179 | 239 | 44 | 0.184 | 3 |
| RAD1 | RAD1 | O60671 | Cell cycle checkpoint protein RAD1 | chr5 | GO:0004527 | Not Cancer Driver | No | 29 | 0.103 | 4 | 1 | 0.25 | 0 |
| RAD9A | RAD9A | Q99638 | Cell cycle checkpoint control protein RAD9A | chr11 | GO:0004527 | Not Cancer Driver | No | 34 | 0.087 | 135 | 7 | 0.052 | 0 |
| REXO1 | REXO1 | Q8N1G1 | RNA exonuclease 1 homolog | chr19 | GO:0004527 | Not Cancer Driver | No | 118 | 0.097 | 829 | 82 | 0.099 | 0 |
| REXO4 | REXO4 | Q9GZR2 | RNA exonuclease 4 | chr9 | GO:0004527 | Not Cancer Driver | No | 34 | 0.081 | 298 | 26 | 0.087 | 0 |
| REXO5 | REXO5 | Q96IC2 | RNA exonuclease 5 | chr16 | GO:0004527 | Not Cancer Driver | No | 89 | 0.115 | 101 | 12 | 0.119 | 0 |
| TDP1_ENST00000393454 | TDP1 | Q9NUW8 | Tyrosyl-DNA phosphodiesterase 1 | chr14 | GO:0004527 | Not Cancer Driver | No | 81 | 0.133 | 179 | 25 | 0.14 | 1 |
| TOE1 | TOE1 | Q96GM8 | Target of EGR1 protein 1 | chr1 | GO:0004527 | Not Cancer Driver | No | 44 | 0.086 | 210 | 22 | 0.105 | 10 |
| TREX1_ENST00000625293 | TREX1 | Q9NSU2 | Three-prime repair exonuclease 1 | chr3 | GO:0004527 | Not Cancer Driver | No | 26 | 0.083 | 98 | 10 | 0.102 | 18 |
| TREX2_ENST00000370231 | TREX2 | Q9BQ50 | Three prime repair exonuclease 2 | chrX | GO:0004527 | Not Cancer Driver | No | 33 | 0.14 | 23 | 6 | 0.261 | 0 |
| USB1 | USB1 | Q9BQ65 | U6 snRNA phosphodiesterase 1 | chr16 | GO:0004527 | Not Cancer Driver | No | 28 | 0.106 | 76 | 5 | 0.066 | 0 |
| WRN | WRN | Q14191 | Werner syndrome ATP-dependent helicase | chr8 | GO:0004527 | Census, Compendium | Yes | 164 | 0.115 | 373 | 41 | 0.11 | 2 |
| XRN1 | XRN1 | Q8IZH2 | 5'-3' exoribonuclease 1 | chr3 | GO:0004527 | Not Cancer Driver | No | 213 | 0.125 | 577 | 65 | 0.113 | 0 |
| XRN2 | XRN2 | Q9H0D6 | 5'-3' exoribonuclease 2 | chr20 | GO:0004527 | Not Cancer Driver | No | 129 | 0.136 | 427 | 63 | 0.148 | 0 |
| ZC3H12A | ZC3H12A | Q5D1E8 | Endoribonuclease ZC3H12A | chr1 | GO:0004527 | Not Cancer Driver | No | 90 | 0.15 | 396 | 44 | 0.111 | 0 |