Total number of protein in "GO:0004520" GO term: 37
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| APEX1_ENST00000555414 | APEX1 | P27695 | DNA-(apurinic or apyrimidinic site) endonuclease | chr14 | GO:0004520 | Not Cancer Driver | No | 34 | 0.107 | 103 | 14 | 0.136 | 0 |
| APLF | APLF | Q8IW19 | Aprataxin and PNK-like factor | chr2 | GO:0004520 | Not Cancer Driver | No | 64 | 0.125 | 407 | 57 | 0.14 | 0 |
| DCLRE1C | DCLRE1C | Q96SD1 | Protein artemis | chr10 | GO:0004520 | Not Cancer Driver | No | 76 | 0.11 | 277 | 26 | 0.094 | 3 |
| DFFB_ENST00000378209 | DFFB | O76075 | DNA fragmentation factor subunit beta | chr1 | GO:0004520 | Not Cancer Driver | No | 37 | 0.109 | 27 | 1 | 0.037 | 0 |
| DICER1 | DICER1 | Q9UPY3 | Endoribonuclease Dicer | chr14 | GO:0004520 | Census, Compendium | Yes | 264 | 0.137 | 362 | 45 | 0.124 | 4 |
| DNA2 | DNA2 | P51530 | DNA replication ATP-dependent helicase/nuclease DNA2 | chr10 | GO:0004520 | Not Cancer Driver | No | 120 | 0.113 | 52 | 8 | 0.154 | 3 |
| DNASE1L1 | DNASE1L1 | P49184 | Deoxyribonuclease-1-like 1 | chrX | GO:0004520 | Not Cancer Driver | No | 30 | 0.099 | 0 | 0 | 0.0 | 0 |
| DNASE1L2_ENST00000567494 | DNASE1L2 | Q92874 | Deoxyribonuclease-1-like 2 | chr16 | GO:0004520 | Not Cancer Driver | No | 23 | 0.077 | 15 | 1 | 0.067 | 0 |
| DNASE1L3 | DNASE1L3 | Q13609 | Deoxyribonuclease gamma | chr3 | GO:0004520 | Not Cancer Driver | No | 43 | 0.141 | 15 | 4 | 0.267 | 0 |
| DNASE1_ENST00000246949 | DNASE1 | P24855 | Deoxyribonuclease-1 | chr16 | GO:0004520 | Not Cancer Driver | No | 24 | 0.085 | 0 | 0 | 0.0 | 0 |
| DNASE2 | DNASE2 | O00115 | Deoxyribonuclease-2-alpha | chr19 | GO:0004520 | Not Cancer Driver | No | 46 | 0.128 | 48 | 7 | 0.146 | 0 |
| DNASE2B | DNASE2B | Q8WZ79 | Deoxyribonuclease-2-beta | chr1 | GO:0004520 | Not Cancer Driver | No | 53 | 0.147 | 14 | 1 | 0.071 | 0 |
| ENDOG | ENDOG | Q14249 | Endonuclease G, mitochondrial | chr9 | GO:0004520 | Not Cancer Driver | No | 11 | 0.037 | 61 | 1 | 0.016 | 0 |
| ENDOV | ENDOV | Q8N8Q3 | Endonuclease V | chr17 | GO:0004520 | Not Cancer Driver | No | 28 | 0.099 | 43 | 3 | 0.07 | 0 |
| ERCC1_ENST00000589165 | ERCC1 | P07992 | DNA excision repair protein ERCC-1 | chr19 | GO:0004520 | Not Cancer Driver | No | 42 | 0.141 | 105 | 14 | 0.133 | 1 |
| ERCC4 | ERCC4 | Q92889 | DNA repair endonuclease XPF | chr16 | GO:0004520 | Census | Yes | 120 | 0.131 | 225 | 27 | 0.12 | 15 |
| ERCC5 | ERCC5 | P28715 | DNA excision repair protein ERCC-5 | chr13 | GO:0004520 | Census | Yes | 175 | 0.148 | 816 | 121 | 0.148 | 6 |
| EXO1_ENST00000348581 | EXO1 | Q9UQ84 | Exonuclease 1 | chr1 | GO:0004520 | Not Cancer Driver | No | 123 | 0.145 | 472 | 76 | 0.161 | 0 |
| EXOG | EXOG | Q9Y2C4 | Nuclease EXOG, mitochondrial | chr3 | GO:0004520 | Not Cancer Driver | No | 42 | 0.114 | 52 | 1 | 0.019 | 0 |
| FAN1 | FAN1 | Q9Y2M0 | Fanconi-associated nuclease 1 | chr15 | GO:0004520 | Not Cancer Driver | No | 124 | 0.122 | 212 | 27 | 0.127 | 4 |
| FEN1 | FEN1 | P39748 | Flap endonuclease 1 | chr11 | GO:0004520 | Census | Yes | 35 | 0.092 | 111 | 11 | 0.099 | 0 |
| GEN1_ENST00000381254 | GEN1 | Q17RS7 | Flap endonuclease GEN homolog 1 | chr2 | GO:0004520 | Not Cancer Driver | No | 109 | 0.12 | 339 | 52 | 0.153 | 0 |
| MBD4 | MBD4 | O95243 | Methyl-CpG-binding domain protein 4 | chr3 | GO:0004520 | Not Cancer Driver | No | 61 | 0.105 | 268 | 27 | 0.101 | 0 |
| MRE11 | MRE11 | P49959 | Double-strand break repair protein MRE11 | chr11 | GO:0004520 | Not Cancer Driver | No | 84 | 0.119 | 292 | 35 | 0.12 | 1 |
| MUS81 | MUS81 | Q96NY9 | Crossover junction endonuclease MUS81 | chr11 | GO:0004520 | Not Cancer Driver | No | 67 | 0.122 | 232 | 38 | 0.164 | 0 |
| RAD50 | RAD50 | Q92878 | DNA repair protein RAD50 | chr5 | GO:0004520 | Not Cancer Driver | No | 157 | 0.12 | 730 | 84 | 0.115 | 0 |
| RAD51C | RAD51C | O43502 | DNA repair protein RAD51 homolog 3 | chr17 | GO:0004520 | Not Cancer Driver | No | 47 | 0.125 | 18 | 2 | 0.111 | 6 |
| RAG1 | RAG1 | P15918 | V(D)J recombination-activating protein 1 | chr11 | GO:0004520 | Not Cancer Driver | No | 204 | 0.196 | 208 | 43 | 0.207 | 36 |
| RBBP8_ENST00000327155 | RBBP8 | Q99708 | DNA endonuclease RBBP8 | chr18 | GO:0004520 | Not Cancer Driver | No | 99 | 0.11 | 750 | 76 | 0.101 | 1 |
| RPS3_ENST00000527446 | RPS3 | P23396 | 40S ribosomal protein S3 | chr11 | GO:0004520 | Not Cancer Driver | No | 22 | 0.091 | 48 | 4 | 0.083 | 0 |
| SETMAR | SETMAR | Q53H47 | Histone-lysine N-methyltransferase SETMAR | chr3 | GO:0004520 | Not Cancer Driver | No | 62 | 0.091 | 154 | 12 | 0.078 | 0 |
| SLX1B | SLX1B | Q9BQ83 | Structure-specific endonuclease subunit SLX1 | chr16 | GO:0004520 | Not Cancer Driver | No | 3 | 0.011 | 80 | 1 | 0.013 | 0 |
| TEFM | TEFM | Q96QE5 | Transcription elongation factor, mitochondrial | chr17 | GO:0004520 | Not Cancer Driver | No | 37 | 0.103 | 26 | 5 | 0.192 | 0 |
| XRCC1 | XRCC1 | P18887 | DNA repair protein XRCC1 | chr19 | GO:0004520 | Not Cancer Driver | No | 85 | 0.134 | 426 | 53 | 0.124 | 1 |
| XRCC3_ENST00000352127 | XRCC3 | O43542 | DNA repair protein XRCC3 | chr14 | GO:0004520 | Not Cancer Driver | No | 24 | 0.069 | 35 | 2 | 0.057 | 1 |
| ZGRF1 | ZGRF1 | Q86YA3 | Protein ZGRF1 | chr4 | GO:0004520 | Not Cancer Driver | No | 216 | 0.103 | 881 | 95 | 0.108 | 0 |
| ZRANB3 | ZRANB3 | Q5FWF4 | DNA annealing helicase and endonuclease ZRANB3 | chr2 | GO:0004520 | Not Cancer Driver | No | 126 | 0.117 | 261 | 31 | 0.119 | 0 |