Total number of protein in "GO:0004519" GO term: 90
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| AGO2 | AGO2 | Q9UKV8 | Protein argonaute-2 | chr8 | GO:0004519 | Not Cancer Driver | No | 126 | 0.147 | 141 | 15 | 0.106 | 11 |
| AGO3 | AGO3 | Q9H9G7 | Protein argonaute-3 | chr1 | GO:0004519 | Not Cancer Driver | No | 110 | 0.128 | 143 | 19 | 0.133 | 0 |
| ANG | ANG | P03950 | Angiogenin | chr14 | GO:0004519 | Not Cancer Driver | No | 19 | 0.129 | 36 | 2 | 0.056 | 14 |
| APEX1_ENST00000555414 | APEX1 | P27695 | DNA-(apurinic or apyrimidinic site) endonuclease | chr14 | GO:0004519 | Not Cancer Driver | No | 34 | 0.107 | 103 | 14 | 0.136 | 0 |
| APEX2 | APEX2 | Q9UBZ4 | DNA-(apurinic or apyrimidinic site) endonuclease 2 | chrX | GO:0004519 | Not Cancer Driver | No | 66 | 0.127 | 148 | 14 | 0.095 | 0 |
| DBR1 | DBR1 | Q9UK59 | Lariat debranching enzyme | chr3 | GO:0004519 | Not Cancer Driver | No | 58 | 0.107 | 185 | 28 | 0.151 | 3 |
| DCLRE1C | DCLRE1C | Q96SD1 | Protein artemis | chr10 | GO:0004519 | Not Cancer Driver | No | 76 | 0.11 | 277 | 26 | 0.094 | 3 |
| DICER1 | DICER1 | Q9UPY3 | Endoribonuclease Dicer | chr14 | GO:0004519 | Census, Compendium | Yes | 264 | 0.137 | 362 | 45 | 0.124 | 4 |
| DIS3 | DIS3 | Q9Y2L1 | Exosome complex exonuclease RRP44 | chr13 | GO:0004519 | Compendium | Yes | 121 | 0.126 | 235 | 32 | 0.136 | 0 |
| DNA2 | DNA2 | P51530 | DNA replication ATP-dependent helicase/nuclease DNA2 | chr10 | GO:0004519 | Not Cancer Driver | No | 120 | 0.113 | 52 | 8 | 0.154 | 3 |
| DNASE1L1 | DNASE1L1 | P49184 | Deoxyribonuclease-1-like 1 | chrX | GO:0004519 | Not Cancer Driver | No | 30 | 0.099 | 0 | 0 | 0.0 | 0 |
| DNASE1L2_ENST00000567494 | DNASE1L2 | Q92874 | Deoxyribonuclease-1-like 2 | chr16 | GO:0004519 | Not Cancer Driver | No | 23 | 0.077 | 15 | 1 | 0.067 | 0 |
| DNASE1L3 | DNASE1L3 | Q13609 | Deoxyribonuclease gamma | chr3 | GO:0004519 | Not Cancer Driver | No | 43 | 0.141 | 15 | 4 | 0.267 | 0 |
| DNASE1_ENST00000246949 | DNASE1 | P24855 | Deoxyribonuclease-1 | chr16 | GO:0004519 | Not Cancer Driver | No | 24 | 0.085 | 0 | 0 | 0.0 | 0 |
| DNASE2 | DNASE2 | O00115 | Deoxyribonuclease-2-alpha | chr19 | GO:0004519 | Not Cancer Driver | No | 46 | 0.128 | 48 | 7 | 0.146 | 0 |
| DNASE2B | DNASE2B | Q8WZ79 | Deoxyribonuclease-2-beta | chr1 | GO:0004519 | Not Cancer Driver | No | 53 | 0.147 | 14 | 1 | 0.071 | 0 |
| DROSHA_ENST00000344624 | DROSHA | Q9NRR4 | Ribonuclease 3 | chr5 | GO:0004519 | Census, Compendium | Yes | 175 | 0.127 | 682 | 100 | 0.147 | 0 |
| EDC3 | EDC3 | Q96F86 | Enhancer of mRNA-decapping protein 3 | chr15 | GO:0004519 | Not Cancer Driver | No | 43 | 0.085 | 185 | 22 | 0.119 | 1 |
| ELAC1 | ELAC1 | Q9H777 | Zinc phosphodiesterase ELAC protein 1 | chr18 | GO:0004519 | Not Cancer Driver | No | 40 | 0.11 | 47 | 4 | 0.085 | 0 |
| ELAC2 | ELAC2 | Q9BQ52 | Zinc phosphodiesterase ELAC protein 2 | chr17 | GO:0004519 | Not Cancer Driver | No | 86 | 0.104 | 208 | 30 | 0.144 | 10 |
| EME1_ENST00000338165 | EME1 | Q96AY2 | Crossover junction endonuclease EME1 | chr17 | GO:0004519 | Not Cancer Driver | No | 56 | 0.098 | 296 | 30 | 0.101 | 0 |
| EME2 | EME2 | A4GXA9 | Probable crossover junction endonuclease EME2 | chr16 | GO:0004519 | Not Cancer Driver | No | 28 | 0.074 | 125 | 7 | 0.056 | 0 |
| ENDOD1 | ENDOD1 | O94919 | Endonuclease domain-containing 1 protein | chr11 | GO:0004519 | Not Cancer Driver | No | 51 | 0.102 | 72 | 9 | 0.125 | 0 |
| ENDOG | ENDOG | Q14249 | Endonuclease G, mitochondrial | chr9 | GO:0004519 | Not Cancer Driver | No | 11 | 0.037 | 61 | 1 | 0.016 | 0 |
| ENDOV | ENDOV | Q8N8Q3 | Endonuclease V | chr17 | GO:0004519 | Not Cancer Driver | No | 28 | 0.099 | 43 | 3 | 0.07 | 0 |
| ERCC1_ENST00000589165 | ERCC1 | P07992 | DNA excision repair protein ERCC-1 | chr19 | GO:0004519 | Not Cancer Driver | No | 42 | 0.141 | 105 | 14 | 0.133 | 1 |
| ERCC4 | ERCC4 | Q92889 | DNA repair endonuclease XPF | chr16 | GO:0004519 | Census | Yes | 120 | 0.131 | 225 | 27 | 0.12 | 15 |
| ERCC5 | ERCC5 | P28715 | DNA excision repair protein ERCC-5 | chr13 | GO:0004519 | Census | Yes | 175 | 0.148 | 816 | 121 | 0.148 | 6 |
| ERN2 | ERN2 | Q76MJ5 | Serine/threonine-protein kinase/endoribonuclease IRE2 | chr16 | GO:0004519 | Not Cancer Driver | No | 192 | 0.207 | 213 | 45 | 0.211 | 0 |
| EXO1_ENST00000348581 | EXO1 | Q9UQ84 | Exonuclease 1 | chr1 | GO:0004519 | Not Cancer Driver | No | 123 | 0.145 | 472 | 76 | 0.161 | 0 |
| EXOG | EXOG | Q9Y2C4 | Nuclease EXOG, mitochondrial | chr3 | GO:0004519 | Not Cancer Driver | No | 42 | 0.114 | 52 | 1 | 0.019 | 0 |
| FAN1 | FAN1 | Q9Y2M0 | Fanconi-associated nuclease 1 | chr15 | GO:0004519 | Not Cancer Driver | No | 124 | 0.122 | 212 | 27 | 0.127 | 4 |
| FEN1 | FEN1 | P39748 | Flap endonuclease 1 | chr11 | GO:0004519 | Census | Yes | 35 | 0.092 | 111 | 11 | 0.099 | 0 |
| G3BP1 | G3BP1 | Q13283 | Ras GTPase-activating protein-binding protein 1 | chr5 | GO:0004519 | Not Cancer Driver | No | 85 | 0.182 | 352 | 65 | 0.185 | 0 |
| GEN1_ENST00000381254 | GEN1 | Q17RS7 | Flap endonuclease GEN homolog 1 | chr2 | GO:0004519 | Not Cancer Driver | No | 109 | 0.12 | 339 | 52 | 0.153 | 0 |
| KIAA0391 | PRORP | O15091 | Mitochondrial ribonuclease P catalytic subunit | chr14 | GO:0004519 | Not Cancer Driver | No | 62 | 0.106 | 60 | 12 | 0.2 | 0 |
| LAS1L | LAS1L | Q9Y4W2 | Ribosomal biogenesis protein LAS1L | chrX | GO:0004519 | Not Cancer Driver | No | 100 | 0.136 | 279 | 49 | 0.176 | 0 |
| MRE11 | MRE11 | P49959 | Double-strand break repair protein MRE11 | chr11 | GO:0004519 | Not Cancer Driver | No | 84 | 0.119 | 292 | 35 | 0.12 | 1 |
| MRPL44 | MRPL44 | Q9H9J2 | 39S ribosomal protein L44, mitochondrial | chr2 | GO:0004519 | Not Cancer Driver | No | 37 | 0.111 | 45 | 2 | 0.044 | 1 |
| MUS81 | MUS81 | Q96NY9 | Crossover junction endonuclease MUS81 | chr11 | GO:0004519 | Not Cancer Driver | No | 67 | 0.122 | 232 | 38 | 0.164 | 0 |
| N4BP2 | N4BP2 | Q86UW6 | NEDD4-binding protein 2 | chr4 | GO:0004519 | Census | Yes | 185 | 0.105 | 965 | 104 | 0.108 | 0 |
| NTHL1 | NTHL1 | P78549 | Endonuclease III-like protein 1 | chr16 | GO:0004519 | Census | Yes | 38 | 0.122 | 147 | 18 | 0.122 | 0 |
| NUDT12 | NUDT12 | Q9BQG2 | NAD-capped RNA hydrolase NUDT12 | chr5 | GO:0004519 | Not Cancer Driver | No | 65 | 0.141 | 11 | 2 | 0.182 | 0 |
| NUDT16L1 | NUDT16L1 | Q9BRJ7 | Tudor-interacting repair regulator protein | chr16 | GO:0004519 | Not Cancer Driver | No | 16 | 0.076 | 6 | 0 | 0.0 | 0 |
| NUDT16_ENST00000521288 | NUDT16 | Q96DE0 | U8 snoRNA-decapping enzyme | chr3 | GO:0004519 | Not Cancer Driver | No | 29 | 0.149 | 8 | 1 | 0.125 | 0 |
| OGG1_ENST00000344629 | OGG1 | O15527 | N-glycosylase/DNA lyase | chr3 | GO:0004519 | Not Cancer Driver | No | 37 | 0.107 | 71 | 12 | 0.169 | 0 |
| PELO | PELO | Q9BRX2 | Protein pelota homolog | chr5 | GO:0004519 | Not Cancer Driver | No | 38 | 0.099 | 67 | 10 | 0.149 | 0 |
| PGBD5 | PGBD5 | Q8N414 | PiggyBac transposable element-derived protein 5 | chr1 | GO:0004519 | Not Cancer Driver | No | 73 | 0.139 | 126 | 1 | 0.008 | 0 |
| PLD6 | PLD6 | Q8N2A8 | Mitochondrial cardiolipin hydrolase | chr17 | GO:0004519 | Not Cancer Driver | No | 27 | 0.107 | 24 | 6 | 0.25 | 0 |
| PMS2 | PMS2 | P54278 | Mismatch repair endonuclease PMS2 | chr7 | GO:0004519 | Census, Compendium | Yes | 117 | 0.136 | 331 | 44 | 0.133 | 9 |
| PNKP | PNKP | Q96T60 | Bifunctional polynucleotide phosphatase/kinase | chr19 | GO:0004519 | Not Cancer Driver | No | 53 | 0.102 | 177 | 23 | 0.13 | 4 |
| POP1_ENST00000349693 | POP1 | Q99575 | Ribonucleases P/MRP protein subunit POP1 | chr8 | GO:0004519 | Not Cancer Driver | No | 161 | 0.157 | 495 | 75 | 0.152 | 3 |
| POP4 | POP4 | O95707 | Ribonuclease P protein subunit p29 | chr19 | GO:0004519 | Not Cancer Driver | No | 25 | 0.114 | 53 | 9 | 0.17 | 0 |
| POP5 | POP5 | Q969H6 | Ribonuclease P/MRP protein subunit POP5 | chr12 | GO:0004519 | Not Cancer Driver | No | 17 | 0.104 | 9 | 2 | 0.222 | 0 |
| POP7 | POP7 | O75817 | Ribonuclease P protein subunit p20 | chr7 | GO:0004519 | Not Cancer Driver | No | 20 | 0.143 | 59 | 13 | 0.22 | 0 |
| PPP1R8 | PPP1R8 | Q12972 | Nuclear inhibitor of protein phosphatase 1 | chr1 | GO:0004519 | Not Cancer Driver | No | 24 | 0.068 | 251 | 19 | 0.076 | 0 |
| PXDNL | PXDNL | A1KZ92 | Probable oxidoreductase PXDNL | chr8 | GO:0004519 | Not Cancer Driver | No | 554 | 0.379 | 397 | 171 | 0.431 | 0 |
| RAD50 | RAD50 | Q92878 | DNA repair protein RAD50 | chr5 | GO:0004519 | Not Cancer Driver | No | 157 | 0.12 | 730 | 84 | 0.115 | 0 |
| RAD51C | RAD51C | O43502 | DNA repair protein RAD51 homolog 3 | chr17 | GO:0004519 | Not Cancer Driver | No | 47 | 0.125 | 18 | 2 | 0.111 | 6 |
| RAG1 | RAG1 | P15918 | V(D)J recombination-activating protein 1 | chr11 | GO:0004519 | Not Cancer Driver | No | 204 | 0.196 | 208 | 43 | 0.207 | 36 |
| RBBP8_ENST00000327155 | RBBP8 | Q99708 | DNA endonuclease RBBP8 | chr18 | GO:0004519 | Not Cancer Driver | No | 99 | 0.11 | 750 | 76 | 0.101 | 1 |
| REXO4 | REXO4 | Q9GZR2 | RNA exonuclease 4 | chr9 | GO:0004519 | Not Cancer Driver | No | 34 | 0.081 | 298 | 26 | 0.087 | 0 |
| RIDA | RIDA | P52758 | 2-iminobutanoate/2-iminopropanoate deaminase | chr8 | GO:0004519 | Not Cancer Driver | No | 20 | 0.146 | 3 | 0 | 0.0 | 0 |
| RNASE11_ENST00000620912 | RNASE11 | Q8TAA1 | Probable ribonuclease 11 | chr14 | GO:0004519 | Not Cancer Driver | No | 42 | 0.211 | 29 | 7 | 0.241 | 0 |
| RNASE1_ENST00000412779 | RNASE1 | P07998 | Ribonuclease pancreatic | chr14 | GO:0004519 | Not Cancer Driver | No | 17 | 0.109 | 49 | 11 | 0.224 | 0 |
| RNASE2 | RNASE2 | P10153 | Non-secretory ribonuclease | chr14 | GO:0004519 | Not Cancer Driver | No | 30 | 0.186 | 20 | 4 | 0.2 | 0 |
| RNASE3 | RNASE3 | P12724 | Eosinophil cationic protein | chr14 | GO:0004519 | Not Cancer Driver | No | 37 | 0.231 | 8 | 0 | 0.0 | 0 |
| RNASE4_ENST00000555597 | RNASE4 | P34096 | Ribonuclease 4 | chr14 | GO:0004519 | Not Cancer Driver | No | 24 | 0.163 | 9 | 2 | 0.222 | 0 |
| RNASE6 | RNASE6 | Q93091 | Ribonuclease K6 | chr14 | GO:0004519 | Not Cancer Driver | No | 26 | 0.173 | 0 | 0 | 0.0 | 0 |
| RNASE7 | RNASE7 | Q9H1E1 | Ribonuclease 7 | chr14 | GO:0004519 | Not Cancer Driver | No | 27 | 0.173 | 42 | 4 | 0.095 | 0 |
| RNASE8 | RNASE8 | Q8TDE3 | Ribonuclease 8 | chr14 | GO:0004519 | Not Cancer Driver | No | 18 | 0.117 | 17 | 2 | 0.118 | 0 |
| RNASEH1 | RNASEH1 | O60930 | Ribonuclease H1 | chr2 | GO:0004519 | Not Cancer Driver | No | 33 | 0.115 | 124 | 20 | 0.161 | 2 |
| RNASEH2A | RNASEH2A | O75792 | Ribonuclease H2 subunit A | chr19 | GO:0004519 | Not Cancer Driver | No | 42 | 0.14 | 31 | 3 | 0.097 | 7 |
| RNASET2_ENST00000476238 | RNASET2 | O00584 | Ribonuclease T2 | chr6 | GO:0004519 | Not Cancer Driver | No | 32 | 0.125 | 37 | 3 | 0.081 | 1 |
| RPP14_ENST00000295959 | RPP14 | O95059 | Ribonuclease P protein subunit p14 | chr3 | GO:0004519 | Not Cancer Driver | No | 8 | 0.065 | 0 | 0 | 0.0 | 0 |
| RPP21_ENST00000442966 | RPP21 | Q9H633 | Ribonuclease P protein subunit p21 | chr6 | GO:0004519 | Not Cancer Driver | No | 16 | 0.104 | 51 | 4 | 0.078 | 0 |
| RPP25 | RPP25 | Q9BUL9 | Ribonuclease P protein subunit p25 | chr15 | GO:0004519 | Not Cancer Driver | No | 11 | 0.055 | 162 | 11 | 0.068 | 0 |
| RPP30_ENST00000371703 | RPP30 | P78346 | Ribonuclease P protein subunit p30 | chr10 | GO:0004519 | Not Cancer Driver | No | 28 | 0.104 | 21 | 2 | 0.095 | 0 |
| RPP38_ENST00000378202 | RPP38 | P78345 | Ribonuclease P protein subunit p38 | chr10 | GO:0004519 | Not Cancer Driver | No | 36 | 0.127 | 118 | 19 | 0.161 | 0 |
| RPP40 | RPP40 | O75818 | Ribonuclease P protein subunit p40 | chr6 | GO:0004519 | Not Cancer Driver | No | 51 | 0.14 | 5 | 0 | 0.0 | 0 |
| SETMAR | SETMAR | Q53H47 | Histone-lysine N-methyltransferase SETMAR | chr3 | GO:0004519 | Not Cancer Driver | No | 62 | 0.091 | 154 | 12 | 0.078 | 0 |
| SLX1B | SLX1B | Q9BQ83 | Structure-specific endonuclease subunit SLX1 | chr16 | GO:0004519 | Not Cancer Driver | No | 3 | 0.011 | 80 | 1 | 0.013 | 0 |
| SND1 | SND1 | Q7KZF4 | Staphylococcal nuclease domain-containing protein 1 | chr7 | GO:0004519 | Census | Yes | 127 | 0.14 | 258 | 48 | 0.186 | 0 |
| TEFM | TEFM | Q96QE5 | Transcription elongation factor, mitochondrial | chr17 | GO:0004519 | Not Cancer Driver | No | 37 | 0.103 | 26 | 5 | 0.192 | 0 |
| TSEN2 | TSEN2 | Q8NCE0 | tRNA-splicing endonuclease subunit Sen2 | chr3 | GO:0004519 | Not Cancer Driver | No | 54 | 0.116 | 153 | 17 | 0.111 | 1 |
| TSEN34_ENST00000396383 | TSEN34 | Q9BSV6 | tRNA-splicing endonuclease subunit Sen34 | chr19 | GO:0004519 | Not Cancer Driver | No | 40 | 0.129 | 176 | 22 | 0.125 | 1 |
| TSN | TSN | Q15631 | Translin | chr2 | GO:0004519 | Not Cancer Driver | No | 30 | 0.132 | 0 | 0 | 0.0 | 0 |
| XRCC1 | XRCC1 | P18887 | DNA repair protein XRCC1 | chr19 | GO:0004519 | Not Cancer Driver | No | 85 | 0.134 | 426 | 53 | 0.124 | 1 |
| XRCC3_ENST00000352127 | XRCC3 | O43542 | DNA repair protein XRCC3 | chr14 | GO:0004519 | Not Cancer Driver | No | 24 | 0.069 | 35 | 2 | 0.057 | 1 |
| ZGRF1 | ZGRF1 | Q86YA3 | Protein ZGRF1 | chr4 | GO:0004519 | Not Cancer Driver | No | 216 | 0.103 | 881 | 95 | 0.108 | 0 |