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Total number of protein in "GO:0004175" GO term:  134

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ACE ACE P12821 Angiotensin-converting enzyme chr17 GO:0004175 Not Cancer Driver No 201 0.154 86 8 0.093 0
ACE2 ACE2 Q9BYF1 Angiotensin-converting enzyme 2 chrX GO:0004175 Not Cancer Driver No 104 0.129 68 5 0.074 0
ADAM10 ADAM10 O14672 Disintegrin and metalloproteinase domain-containing protein 10 chr15 GO:0004175 Not Cancer Driver No 88 0.118 156 20 0.128 4
ADAM17 ADAM17 P78536 Disintegrin and metalloproteinase domain-containing protein 17 chr2 GO:0004175 Not Cancer Driver No 80 0.097 182 17 0.093 0
ADAM19_ENST00000517905 ADAM19 Q9H013 Disintegrin and metalloproteinase domain-containing protein 19 chr5 GO:0004175 Not Cancer Driver No 172 0.18 370 77 0.208 0
ADAM28 ADAM28 Q9UKQ2 Disintegrin and metalloproteinase domain-containing protein 28 chr8 GO:0004175 Not Cancer Driver No 193 0.249 123 24 0.195 0
ADAM7 ADAM7 Q9H2U9 Disintegrin and metalloproteinase domain-containing protein 7 chr8 GO:0004175 Not Cancer Driver No 241 0.32 55 22 0.4 0
ADAMTS15 ADAMTS15 Q8TE58 A disintegrin and metalloproteinase with thrombospondin motifs 15 chr11 GO:0004175 Not Cancer Driver No 127 0.134 141 25 0.177 0
ADAMTS3 ADAMTS3 O15072 A disintegrin and metalloproteinase with thrombospondin motifs 3 chr4 GO:0004175 Not Cancer Driver No 253 0.21 295 78 0.264 2
ADAMTS5 ADAMTS5 Q9UNA0 A disintegrin and metalloproteinase with thrombospondin motifs 5 chr21 GO:0004175 Not Cancer Driver No 227 0.244 148 33 0.223 0
ADGB ADGB Q8N7X0 Androglobin chr6 GO:0004175 Not Cancer Driver No 141 0.085 706 68 0.096 0
ADGRG6_ENST00000230173 ADGRG6 Q86SQ4 Adhesion G-protein coupled receptor G6 chr6 GO:0004175 Not Cancer Driver No 132 0.108 23 0 0.0 2
ASPRV1 ASPRV1 Q53RT3 Retroviral-like aspartic protease 1 chr2 GO:0004175 Not Cancer Driver No 66 0.192 85 18 0.212 3
ATG4B ATG4B Q9Y4P1 Cysteine protease ATG4B chr2 GO:0004175 Not Cancer Driver No 34 0.087 13 2 0.154 0
BACE1 BACE1 P56817 Beta-secretase 1 chr11 GO:0004175 Not Cancer Driver No 55 0.11 53 5 0.094 0
BACE2 BACE2 Q9Y5Z0 Beta-secretase 2 chr21 GO:0004175 Not Cancer Driver No 61 0.118 23 2 0.087 0
CAPN10 CAPN10 Q9HC96 Calpain-10 chr2 GO:0004175 Not Cancer Driver No 87 0.129 52 6 0.115 0
CAPN11 CAPN11 Q9UMQ6 Calpain-11 chr6 GO:0004175 Not Cancer Driver No 96 0.13 103 12 0.117 0
CAPN12 CAPN12 Q6ZSI9 Calpain-12 chr19 GO:0004175 Not Cancer Driver No 83 0.115 62 9 0.145 0
CAPN13 CAPN13 Q6MZZ7 Calpain-13 chr2 GO:0004175 Not Cancer Driver No 155 0.232 73 24 0.329 0
CAPN14 CAPN14 A8MX76 Calpain-14 chr2 GO:0004175 Not Cancer Driver No 47 0.069 22 2 0.091 0
CAPN15 CAPN15 O75808 Calpain-15 chr16 GO:0004175 Not Cancer Driver No 98 0.09 385 29 0.075 0
CAPN1_ENST00000533129 CAPN1 P07384 Calpain-1 catalytic subunit chr11 GO:0004175 Not Cancer Driver No 68 0.095 32 2 0.062 1
CAPN2 CAPN2 P17655 Calpain-2 catalytic subunit chr1 GO:0004175 Not Cancer Driver No 81 0.116 46 11 0.239 0
CAPN3 CAPN3 P20807 Calpain-3 chr15 GO:0004175 Not Cancer Driver No 111 0.135 168 11 0.065 52
CAPN5 CAPN5 O15484 Calpain-5 chr11 GO:0004175 Not Cancer Driver No 103 0.161 110 25 0.227 2
CAPN6 CAPN6 Q9Y6Q1 Calpain-6 chrX GO:0004175 Not Cancer Driver No 156 0.243 19 8 0.421 0
CAPN7 CAPN7 Q9Y6W3 Calpain-7 chr3 GO:0004175 Not Cancer Driver No 80 0.098 92 9 0.098 0
CAPN8 CAPN8 A6NHC0 Calpain-8 chr1 GO:0004175 Not Cancer Driver No 36 0.051 76 6 0.079 0
CAPN9 CAPN9 O14815 Calpain-9 chr1 GO:0004175 Not Cancer Driver No 110 0.159 81 17 0.21 0
CAPNS1 CAPNS1 P04632 Calpain small subunit 1 chr19 GO:0004175 Not Cancer Driver No 30 0.112 58 5 0.086 0
CAPNS2 CAPNS2 Q96L46 Calpain small subunit 2 chr16 GO:0004175 Not Cancer Driver No 21 0.085 56 5 0.089 0
CASP1 CASP1 P29466 Caspase-1 chr11 GO:0004175 Not Cancer Driver No 79 0.196 87 18 0.207 0
CASP10_ENST00000272879 CASP10 Q92851 Caspase-10 chr2 GO:0004175 Not Cancer Driver No 57 0.109 126 17 0.135 3
CASP12 CASP12 Q6UXS9 Inactive caspase-12 chr11 GO:0004175 Not Cancer Driver No 12 0.035 31 1 0.032 0
CASP14 CASP14 P31944 Caspase-14 chr19 GO:0004175 Not Cancer Driver No 50 0.207 84 13 0.155 0
CASP2 CASP2 P42575 Caspase-2 chr7 GO:0004175 Not Cancer Driver No 63 0.139 42 12 0.286 0
CASP3 CASP3 P42574 Caspase-3 chr4 GO:0004175 Census Yes 32 0.116 62 5 0.081 0
CASP4 CASP4 P49662 Caspase-4 chr11 GO:0004175 Not Cancer Driver No 56 0.149 102 14 0.137 0
CASP5_ENST00000260315 CASP5 P51878 Caspase-5 chr11 GO:0004175 Not Cancer Driver No 103 0.237 61 17 0.279 0
CASP6 CASP6 P55212 Caspase-6 chr4 GO:0004175 Not Cancer Driver No 28 0.096 24 4 0.167 0
CASP7_ENST00000345633 CASP7 P55210 Caspase-7 chr10 GO:0004175 Not Cancer Driver No 38 0.125 73 10 0.137 0
CASP8_ENST00000432109 CASP8 Q14790 Caspase-8 chr2 GO:0004175 Census, Compendium Yes 142 0.296 106 12 0.113 1
CASP9 CASP9 P55211 Caspase-9 chr1 GO:0004175 Census Yes 49 0.118 71 7 0.099 0
CELA2A CELA2A P08217 Chymotrypsin-like elastase family member 2A chr1 GO:0004175 Not Cancer Driver No 39 0.145 4 4 1.0 2
CFLAR CFLAR O15519 CASP8 and FADD-like apoptosis regulator chr2 GO:0004175 Not Cancer Driver No 40 0.083 44 2 0.045 0
CLPP CLPP Q16740 ATP-dependent Clp protease proteolytic subunit, mitochondrial chr19 GO:0004175 Not Cancer Driver No 22 0.079 83 9 0.108 3
CMA1 CMA1 P23946 Chymase chr14 GO:0004175 Not Cancer Driver No 47 0.19 9 1 0.111 0
CORIN CORIN Q9Y5Q5 Atrial natriuretic peptide-converting enzyme chr4 GO:0004175 Not Cancer Driver No 208 0.2 60 13 0.217 2
CPNE1_ENST00000352393 CPNE1 Q99829 Copine-1 chr20 GO:0004175 Not Cancer Driver No 74 0.138 80 7 0.087 0
CPS1_ENST00000233072 CPS1 P31327 Carbamoyl-phosphate synthase [ammonia], mitochondrial chr2 GO:0004175 Not Cancer Driver No 368 0.245 73 22 0.301 140
CTSD CTSD P07339 Cathepsin D chr11 GO:0004175 Not Cancer Driver No 57 0.138 6 1 0.167 2
CTSE CTSE P14091 Cathepsin E chr1 GO:0004175 Not Cancer Driver No 59 0.149 23 2 0.087 0
CTSH CTSH P09668 Pro-cathepsin H chr15 GO:0004175 Not Cancer Driver No 45 0.134 4 0 0.0 0
DDI1 DDI1 Q8WTU0 Protein DDI1 homolog 1 chr11 GO:0004175 Not Cancer Driver No 151 0.381 166 73 0.44 0
DDI2 DDI2 Q5TDH0 Protein DDI1 homolog 2 chr1 GO:0004175 Not Cancer Driver No 47 0.118 187 30 0.16 0
ECE1 ECE1 P42892 Endothelin-converting enzyme 1 chr1 GO:0004175 Not Cancer Driver No 118 0.153 99 26 0.263 1
ELANE_ENST00000263621 ELANE P08246 Neutrophil elastase chr19 GO:0004175 Not Cancer Driver No 39 0.146 18 3 0.167 89
ERAP1_ENST00000443439 ERAP1 Q9NZ08 Endoplasmic reticulum aminopeptidase 1 chr5 GO:0004175 Not Cancer Driver No 78 0.083 70 2 0.029 0
ERAP2 ERAP2 Q6P179 Endoplasmic reticulum aminopeptidase 2 chr5 GO:0004175 Not Cancer Driver No 97 0.101 23 4 0.174 0
F9 F9 P00740 Coagulation factor IX chrX GO:0004175 Not Cancer Driver No 121 0.262 40 16 0.4 141
FAP FAP Q12884 Prolyl endopeptidase FAP chr2 GO:0004175 Not Cancer Driver No 158 0.208 6 2 0.333 0
FURIN_ENST00000610579 FURIN P09958 Furin chr15 GO:0004175 Not Cancer Driver No 93 0.117 283 35 0.124 0
GPAA1 GPAA1 O43292 Glycosylphosphatidylinositol anchor attachment 1 protein chr8 GO:0004175 Not Cancer Driver No 55 0.089 20 3 0.15 5
HGF_ENST00000644543 HGF P14210 Hepatocyte growth factor chr7 GO:0004175 Compendium Yes 233 0.32 43 16 0.372 0
HM13_ENST00000340852 HM13 Q8TCT9 Minor histocompatibility antigen H13 chr20 GO:0004175 Not Cancer Driver No 42 0.111 61 6 0.098 0
HTRA3 HTRA3 P83110 Serine protease HTRA3 chr4 GO:0004175 Not Cancer Driver No 64 0.141 57 11 0.193 0
HTRA4 HTRA4 P83105 Serine protease HTRA4 chr8 GO:0004175 Not Cancer Driver No 57 0.12 15 0 0.0 0
IDE IDE P14735 Insulin-degrading enzyme chr10 GO:0004175 Not Cancer Driver No 90 0.088 96 8 0.083 0
JMJD7 JMJD7 P0C870 Bifunctional peptidase and (3S)-lysyl hydroxylase JMJD7 chr15 GO:0004175 Not Cancer Driver No 40 0.127 0 0 0.0 0
KDM8_ENST00000286096 KDM8 Q8N371 Bifunctional peptidase and arginyl-hydroxylase JMJD5 chr16 GO:0004175 Not Cancer Driver No 52 0.125 29 6 0.207 0
KLK3 KLK3 P07288 Prostate-specific antigen chr19 GO:0004175 Not Cancer Driver No 68 0.261 6 1 0.167 0
LPA LPA P08519 Apolipoprotein(a) chr6 GO:0004175 Not Cancer Driver No 365 0.179 884 148 0.167 0
MALT1 MALT1 Q9UDY8 Mucosa-associated lymphoid tissue lymphoma translocation protein 1 chr18 GO:0004175 Census, Compendium Yes 75 0.091 139 12 0.086 1
MMEL1 MMEL1 Q495T6 Membrane metallo-endopeptidase-like 1 chr1 GO:0004175 Not Cancer Driver No 117 0.15 46 5 0.109 0
MME_ENST00000492661 MME P08473 Neprilysin chr3 GO:0004175 Not Cancer Driver No 189 0.252 40 17 0.425 4
MMP1 MMP1 P03956 Interstitial collagenase chr11 GO:0004175 Not Cancer Driver No 83 0.177 113 18 0.159 0
MMP12 MMP12 P39900 Macrophage metalloelastase chr11 GO:0004175 Not Cancer Driver No 100 0.213 29 5 0.172 0
MMP13 MMP13 P45452 Collagenase 3 chr11 GO:0004175 Not Cancer Driver No 113 0.24 59 16 0.271 5
MMP14 MMP14 P50281 Matrix metalloproteinase-14 chr14 GO:0004175 Not Cancer Driver No 64 0.11 118 11 0.093 1
MMP2 MMP2 P08253 72 kDa type IV collagenase chr16 GO:0004175 Not Cancer Driver No 123 0.186 29 6 0.207 2
MMP3 MMP3 P08254 Stromelysin-1 chr11 GO:0004175 Not Cancer Driver No 99 0.208 66 14 0.212 0
MMP7 MMP7 P09237 Matrilysin chr11 GO:0004175 Not Cancer Driver No 39 0.146 70 2 0.029 0
MMP8 MMP8 P22894 Neutrophil collagenase chr11 GO:0004175 Not Cancer Driver No 73 0.156 115 19 0.165 0
MMP9 MMP9 P14780 Matrix metalloproteinase-9 chr20 GO:0004175 Not Cancer Driver No 129 0.182 124 26 0.21 0
MST1 MST1 P26927 Hepatocyte growth factor-like protein chr3 GO:0004175 Not Cancer Driver No 110 0.155 168 19 0.113 0
NAPSA NAPSA O96009 Napsin-A chr19 GO:0004175 Not Cancer Driver No 58 0.138 14 1 0.071 0
NCSTN NCSTN Q92542 Nicastrin chr1 GO:0004175 Not Cancer Driver No 94 0.133 72 11 0.153 1
NRIP2 NRIP2 Q9BQI9 Nuclear receptor-interacting protein 2 chr12 GO:0004175 Not Cancer Driver No 32 0.114 158 15 0.095 0
NRIP3 NRIP3 Q9NQ35 Nuclear receptor-interacting protein 3 chr11 GO:0004175 Not Cancer Driver No 34 0.141 111 16 0.144 0
PARL PARL Q9H300 Presenilins-associated rhomboid-like protein, mitochondrial chr3 GO:0004175 Not Cancer Driver No 49 0.129 28 5 0.179 0
PCSK5 PCSK5 Q92824 Proprotein convertase subtilisin/kexin type 5 chr9 GO:0004175 Not Cancer Driver No 319 0.172 168 25 0.149 0
PCSK6 PCSK6 P29122 Proprotein convertase subtilisin/kexin type 6 chr15 GO:0004175 Not Cancer Driver No 138 0.142 207 45 0.217 0
PGA3 PGA3 P0DJD8 Pepsin A-3 chr11 GO:0004175 Not Cancer Driver No 19 0.049 24 1 0.042 0
PGA4 PGA4 P0DJD7 Pepsin A-4 chr11 GO:0004175 Not Cancer Driver No 0 0.0 24 0 0.0 0
PGA5 PGA5 P0DJD9 Pepsin A-5 chr11 GO:0004175 Not Cancer Driver No 25 0.064 24 2 0.083 0
PGC PGC P20142 Gastricsin chr6 GO:0004175 Not Cancer Driver No 60 0.155 20 1 0.05 0
PIDD1 PIDD1 Q9HB75 p53-induced death domain-containing protein 1 chr11 GO:0004175 Not Cancer Driver No 93 0.102 137 14 0.102 0
PIGK PIGK Q92643 GPI-anchor transamidase chr1 GO:0004175 Not Cancer Driver No 54 0.137 37 9 0.243 5
PIP PIP P12273 Prolactin-inducible protein chr7 GO:0004175 Not Cancer Driver No 42 0.288 0 0 0.0 0
PLG PLG P00747 Plasminogen chr6 GO:0004175 Not Cancer Driver No 242 0.299 230 64 0.278 9
PREP PREP P48147 Prolyl endopeptidase chr6 GO:0004175 Not Cancer Driver No 87 0.123 23 1 0.043 0
PRSS50 PRSS50 Q9UI38 Probable threonine protease PRSS50 chr3 GO:0004175 Not Cancer Driver No 104 0.27 63 26 0.413 0
PSEN1 PSEN1 P49768 Presenilin-1 chr14 GO:0004175 Not Cancer Driver No 61 0.131 134 21 0.157 96
PSEN2 PSEN2 P49810 Presenilin-2 chr1 GO:0004175 Not Cancer Driver No 68 0.152 89 16 0.18 7
PSMA4_ENST00000559082 PSMA4 P25789 Proteasome subunit alpha type-4 chr15 GO:0004175 Not Cancer Driver No 29 0.111 28 9 0.321 0
PSMA6 PSMA6 P60900 Proteasome subunit alpha type-6 chr14 GO:0004175 Not Cancer Driver No 37 0.15 2 1 0.5 0
PSMB1 PSMB1 P20618 Proteasome subunit beta type-1 chr6 GO:0004175 Not Cancer Driver No 25 0.104 14 2 0.143 0
PSMB10 PSMB10 P40306 Proteasome subunit beta type-10 chr16 GO:0004175 Not Cancer Driver No 22 0.081 36 5 0.139 0
PSMB11 PSMB11 A5LHX3 Proteasome subunit beta type-11 chr14 GO:0004175 Not Cancer Driver No 62 0.207 71 11 0.155 0
PSMB2 PSMB2 P49721 Proteasome subunit beta type-2 chr1 GO:0004175 Not Cancer Driver No 24 0.119 0 0 0.0 0
PSMB4 PSMB4 P28070 Proteasome subunit beta type-4 chr1 GO:0004175 Not Cancer Driver No 23 0.087 18 2 0.111 0
PSMB5 PSMB5 P28074 Proteasome subunit beta type-5 chr14 GO:0004175 Not Cancer Driver No 39 0.148 9 0 0.0 0
PSMB6 PSMB6 P28072 Proteasome subunit beta type-6 chr17 GO:0004175 Not Cancer Driver No 19 0.079 22 1 0.045 0
PSMB7 PSMB7 Q99436 Proteasome subunit beta type-7 chr9 GO:0004175 Not Cancer Driver No 25 0.09 26 3 0.115 0
PSMB8 PSMB8 P28062 Proteasome subunit beta type-8 chr6 GO:0004175 Not Cancer Driver No 43 0.156 62 7 0.113 3
PSMB9 PSMB9 P28065 Proteasome subunit beta type-9 chr6 GO:0004175 Not Cancer Driver No 21 0.096 17 1 0.059 1
RCE1 RCE1 Q9Y256 CAAX prenyl protease 2 chr11 GO:0004175 Not Cancer Driver No 40 0.122 0 0 0.0 0
REN REN P00797 Renin chr1 GO:0004175 Not Cancer Driver No 60 0.148 10 0 0.0 3
SENP1 SENP1 Q9P0U3 Sentrin-specific protease 1 chr12 GO:0004175 Not Cancer Driver No 64 0.099 355 44 0.124 0
SENP2 SENP2 Q9HC62 Sentrin-specific protease 2 chr3 GO:0004175 Not Cancer Driver No 73 0.124 285 38 0.133 0
SENP5 SENP5 Q96HI0 Sentrin-specific protease 5 chr3 GO:0004175 Not Cancer Driver No 85 0.113 293 34 0.116 0
SENP6 SENP6 Q9GZR1 Sentrin-specific protease 6 chr6 GO:0004175 Not Cancer Driver No 120 0.108 612 59 0.096 0
SENP7 SENP7 Q9BQF6 Sentrin-specific protease 7 chr3 GO:0004175 Not Cancer Driver No 149 0.142 523 73 0.14 0
SHH SHH Q15465 Sonic hedgehog protein chr7 GO:0004175 Not Cancer Driver No 56 0.121 139 14 0.101 81
SPPL2A SPPL2A Q8TCT8 Signal peptide peptidase-like 2A chr15 GO:0004175 Not Cancer Driver No 55 0.106 3 0 0.0 0
SPPL2B SPPL2B Q8TCT7 Signal peptide peptidase-like 2B chr19 GO:0004175 Not Cancer Driver No 68 0.115 99 17 0.172 0
SPPL2C SPPL2C Q8IUH8 Signal peptide peptidase-like 2C chr17 GO:0004175 Not Cancer Driver No 110 0.161 216 45 0.208 0
SPPL3 SPPL3 Q8TCT6 Signal peptide peptidase-like 3 chr12 GO:0004175 Not Cancer Driver No 45 0.117 23 0 0.0 0
TASP1 TASP1 Q9H6P5 Threonine aspartase 1 chr20 GO:0004175 Not Cancer Driver No 59 0.14 81 11 0.136 1
TMEM59 TMEM59 Q9BXS4 Transmembrane protein 59 chr1 GO:0004175 Not Cancer Driver No 39 0.121 26 3 0.115 0
TPP1 TPP1 O14773 Tripeptidyl-peptidase 1 chr11 GO:0004175 Not Cancer Driver No 67 0.119 92 7 0.076 37
TPP2_ENST00000376065 TPP2 P29144 Tripeptidyl-peptidase 2 chr13 GO:0004175 Not Cancer Driver No 147 0.118 218 40 0.183 1
TRABD2A TRABD2A Q86V40 Metalloprotease TIKI1 chr2 GO:0004175 Not Cancer Driver No 80 0.158 132 35 0.265 0