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Total number of protein in "GO:0003697" GO term:  119

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
APTX_ENST00000379819 APTX Q7Z2E3 Aprataxin chr9 GO:0003697 Not Cancer Driver No 36 0.101 101 6 0.059 9
BLM BLM P54132 Bloom syndrome protein chr15 GO:0003697 Census Yes 153 0.108 667 70 0.105 8
BRCA2_ENST00000544455 BRCA2 P51587 Breast cancer type 2 susceptibility protein chr13 GO:0003697 Census, Compendium Yes 457 0.134 1542 225 0.146 46
C17orf53 HROB Q8N3J3 Homologous recombination OB-fold protein chr17 GO:0003697 Not Cancer Driver No 76 0.117 528 61 0.116 0
CDC45_ENST00000407835 CDC45 O75419 Cell division control protein 45 homolog chr22 GO:0003697 Not Cancer Driver No 73 0.129 66 16 0.242 5
CNBP_ENST00000422453 CNBP P62633 CCHC-type zinc finger nucleic acid binding protein chr3 GO:0003697 Census Yes 11 0.062 19 0 0.0 0
CRY2_ENST00000616080 CRY2 Q49AN0 Cryptochrome-2 chr11 GO:0003697 Not Cancer Driver No 72 0.121 100 12 0.12 0
CTC1 CTC1 Q2NKJ3 CST complex subunit CTC1 chr17 GO:0003697 Not Cancer Driver No 142 0.117 103 8 0.078 9
DDX11 DDX11 Q96FC9 ATP-dependent DNA helicase DDX11 chr12 GO:0003697 Not Cancer Driver No 154 0.159 280 55 0.196 1
DHX36 DHX36 Q9H2U1 ATP-dependent DNA/RNA helicase DHX36 chr3 GO:0003697 Not Cancer Driver No 159 0.158 222 39 0.176 0
DHX9 DHX9 Q08211 ATP-dependent RNA helicase A chr1 GO:0003697 Compendium Yes 182 0.143 331 42 0.127 0
DMC1 DMC1 Q14565 Meiotic recombination protein DMC1/LIM15 homolog chr22 GO:0003697 Not Cancer Driver No 39 0.115 49 5 0.102 0
ERCC1_ENST00000589165 ERCC1 P07992 DNA excision repair protein ERCC-1 chr19 GO:0003697 Not Cancer Driver No 42 0.141 105 14 0.133 1
ERCC4 ERCC4 Q92889 DNA repair endonuclease XPF chr16 GO:0003697 Census Yes 120 0.131 225 27 0.12 15
ERCC5 ERCC5 P28715 DNA excision repair protein ERCC-5 chr13 GO:0003697 Census Yes 175 0.148 816 121 0.148 6
FAM111A FAM111A Q96PZ2 Serine protease FAM111A chr11 GO:0003697 Not Cancer Driver No 78 0.128 169 23 0.136 5
FBH1_ENST00000362091 FBH1 Q8NFZ0 F-box DNA helicase 1 chr10 GO:0003697 Not Cancer Driver No 139 0.133 192 32 0.167 0
FUBP1 FUBP1 Q96AE4 Far upstream element-binding protein 1 chr1 GO:0003697 Census, Compendium Yes 88 0.137 595 85 0.143 0
FUBP3 FUBP3 Q96I24 Far upstream element-binding protein 3 chr9 GO:0003697 Not Cancer Driver No 68 0.119 353 51 0.144 0
HMCES_ENST00000502878 HMCES Q96FZ2 Abasic site processing protein HMCES chr3 GO:0003697 Not Cancer Driver No 37 0.105 131 16 0.122 0
HMGB1_ENST00000405805 HMGB1 P09429 High mobility group protein B1 chr13 GO:0003697 Not Cancer Driver No 25 0.116 203 20 0.099 0
HMGB2 HMGB2 P26583 High mobility group protein B2 chr4 GO:0003697 Not Cancer Driver No 38 0.182 207 38 0.184 0
HNRNPA1 HNRNPA1 P09651 Heterogeneous nuclear ribonucleoprotein A1 chr12 GO:0003697 Not Cancer Driver No 70 0.188 290 58 0.2 4
HNRNPA2B1 HNRNPA2B1 P22626 Heterogeneous nuclear ribonucleoproteins A2/B1 chr7 GO:0003697 Census, Compendium Yes 68 0.193 255 41 0.161 0
HNRNPU HNRNPU Q00839 Heterogeneous nuclear ribonucleoprotein U chr1 GO:0003697 Not Cancer Driver No 77 0.093 504 45 0.089 0
HSF1 HSF1 Q00613 Heat shock factor protein 1 chr8 GO:0003697 Not Cancer Driver No 59 0.112 335 37 0.11 0
HSPD1 HSPD1 P10809 60 kDa heat shock protein, mitochondrial chr2 GO:0003697 Not Cancer Driver No 61 0.106 82 6 0.073 2
IGHMBP2 IGHMBP2 P38935 DNA-binding protein SMUBP-2 chr11 GO:0003697 Not Cancer Driver No 136 0.137 354 53 0.15 31
JCHAIN JCHAIN P01591 Immunoglobulin J chain chr4 GO:0003697 Not Cancer Driver No 37 0.233 9 3 0.333 0
LONP1 LONP1 P36776 Lon protease homolog, mitochondrial chr19 GO:0003697 Not Cancer Driver No 99 0.103 175 15 0.086 10
LRPPRC LRPPRC P42704 Leucine-rich PPR motif-containing protein, mitochondrial chr2 GO:0003697 Not Cancer Driver No 131 0.094 18 2 0.111 1
MAPT_ENST00000262410 MAPT P10636 Microtubule-associated protein tau chr17 GO:0003697 Not Cancer Driver No 128 0.169 750 126 0.168 18
MCM10 MCM10 Q7L590 Protein MCM10 homolog chr10 GO:0003697 Not Cancer Driver No 152 0.174 535 102 0.191 1
MCM2 MCM2 P49736 DNA replication licensing factor MCM2 chr3 GO:0003697 Not Cancer Driver No 104 0.115 275 38 0.138 1
MCM3_ENST00000229854 MCM3 P25205 DNA replication licensing factor MCM3 chr6 GO:0003697 Not Cancer Driver No 92 0.114 310 47 0.152 0
MCM4 MCM4 P33991 DNA replication licensing factor MCM4 chr8 GO:0003697 Not Cancer Driver No 121 0.14 215 35 0.163 0
MCM5 MCM5 P33992 DNA replication licensing factor MCM5 chr22 GO:0003697 Not Cancer Driver No 88 0.12 109 20 0.183 1
MCM6 MCM6 Q14566 DNA replication licensing factor MCM6 chr2 GO:0003697 Not Cancer Driver No 101 0.123 122 13 0.107 0
MCM7 MCM7 P33993 DNA replication licensing factor MCM7 chr7 GO:0003697 Not Cancer Driver No 101 0.14 128 22 0.172 0
MCM8_ENST00000378896 MCM8 Q9UJA3 DNA helicase MCM8 chr20 GO:0003697 Not Cancer Driver No 94 0.112 188 19 0.101 1
MCM9_ENST00000619706 MCM9 Q9NXL9 DNA helicase MCM9 chr6 GO:0003697 Not Cancer Driver No 56 0.049 523 13 0.025 0
MEIOB_ENST00000397344 MEIOB Q8N635 Meiosis-specific with OB domain-containing protein chr16 GO:0003697 Not Cancer Driver No 37 0.084 21 2 0.095 1
MLH1 MLH1 P40692 DNA mismatch repair protein Mlh1 chr3 GO:0003697 Census Yes 92 0.122 208 22 0.106 85
MSH2 MSH2 P43246 DNA mismatch repair protein Msh2 chr2 GO:0003697 Census Yes 92 0.099 37 4 0.108 70
MSH3 MSH3 P20585 DNA mismatch repair protein Msh3 chr5 GO:0003697 Not Cancer Driver No 100 0.088 211 20 0.095 0
MYEF2 MYEF2 Q9P2K5 Myelin expression factor 2 chr15 GO:0003697 Not Cancer Driver No 85 0.142 370 45 0.122 0
NABP1 NABP1 Q96AH0 SOSS complex subunit B2 chr2 GO:0003697 Not Cancer Driver No 25 0.123 102 11 0.108 0
NABP2_ENST00000341463 NABP2 Q9BQ15 SOSS complex subunit B1 chr12 GO:0003697 Not Cancer Driver No 25 0.118 125 17 0.136 0
NEIL3 NEIL3 Q8TAT5 Endonuclease 8-like 3 chr4 GO:0003697 Not Cancer Driver No 80 0.132 131 18 0.137 0
NUCKS1 NUCKS1 Q9H1E3 Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 chr1 GO:0003697 Not Cancer Driver No 30 0.123 243 30 0.123 0
NUP35 NUP35 Q8NFH5 Nucleoporin NUP35 chr2 GO:0003697 Not Cancer Driver No 39 0.12 209 27 0.129 0
PARK7_ENST00000377488 PARK7 Q99497 Parkinson disease protein 7 chr1 GO:0003697 Not Cancer Driver No 11 0.058 30 0 0.0 5
PCBP1 PCBP1 Q15365 Poly(rC)-binding protein 1 chr2 GO:0003697 Census, Compendium Yes 65 0.183 166 24 0.145 0
PCBP2_ENST00000439930 PCBP2 Q15366 Poly(rC)-binding protein 2 chr12 GO:0003697 Not Cancer Driver No 40 0.11 200 24 0.12 0
PMS2 PMS2 P54278 Mismatch repair endonuclease PMS2 chr7 GO:0003697 Census, Compendium Yes 117 0.136 331 44 0.133 9
POLA1_ENST00000379059 POLA1 P09884 DNA polymerase alpha catalytic subunit chrX GO:0003697 Not Cancer Driver No 185 0.127 347 45 0.13 3
POLR2G POLR2G P62487 DNA-directed RNA polymerase II subunit RPB7 chr11 GO:0003697 Not Cancer Driver No 15 0.087 15 1 0.067 0
POLR2H_ENST00000456318 POLR2H P52434 DNA-directed RNA polymerases I, II, and III subunit RPABC3 chr3 GO:0003697 Not Cancer Driver No 16 0.107 14 1 0.071 0
POLR3C POLR3C Q9BUI4 DNA-directed RNA polymerase III subunit RPC3 chr1 GO:0003697 Not Cancer Driver No 60 0.112 161 21 0.13 0
POT1 POT1 Q9NUX5 Protection of telomeres protein 1 chr7 GO:0003697 Census, Compendium Yes 113 0.178 31 6 0.194 9
POU4F1 POU4F1 Q01851 POU domain, class 4, transcription factor 1 chr13 GO:0003697 Not Cancer Driver No 51 0.122 273 34 0.125 1
PURA PURA Q00577 Transcriptional activator protein Pur-alpha chr5 GO:0003697 Not Cancer Driver No 22 0.068 188 10 0.053 6
PURB PURB Q96QR8 Transcriptional activator protein Pur-beta chr7 GO:0003697 Not Cancer Driver No 27 0.087 161 14 0.087 0
RAD18 RAD18 Q9NS91 E3 ubiquitin-protein ligase RAD18 chr3 GO:0003697 Not Cancer Driver No 59 0.119 328 43 0.131 0
RAD23A RAD23A P54725 UV excision repair protein RAD23 homolog A chr19 GO:0003697 Not Cancer Driver No 50 0.138 283 41 0.145 0
RAD23B RAD23B P54727 UV excision repair protein RAD23 homolog B chr9 GO:0003697 Not Cancer Driver No 54 0.132 324 41 0.127 0
RAD50 RAD50 Q92878 DNA repair protein RAD50 chr5 GO:0003697 Not Cancer Driver No 157 0.12 730 84 0.115 0
RAD51AP1 RAD51AP1 Q96B01 RAD51-associated protein 1 chr12 GO:0003697 Not Cancer Driver No 46 0.131 335 43 0.128 0
RAD51AP2 RAD51AP2 Q09MP3 RAD51-associated protein 2 chr2 GO:0003697 Not Cancer Driver No 202 0.174 371 66 0.178 0
RAD51B_ENST00000487270 RAD51B O15315 DNA repair protein RAD51 homolog 2 chr14 GO:0003697 Census Yes 45 0.117 13 0 0.0 0
RAD51D_ENST00000394589 RAD51D O75771 DNA repair protein RAD51 homolog 4 chr17 GO:0003697 Not Cancer Driver No 34 0.104 49 10 0.204 0
RAD51_ENST00000267868 RAD51 Q06609 DNA repair protein RAD51 homolog 1 chr15 GO:0003697 Not Cancer Driver No 42 0.124 47 5 0.106 3
RAD52 RAD52 P43351 DNA repair protein RAD52 homolog chr12 GO:0003697 Not Cancer Driver No 41 0.098 251 30 0.12 0
RAD54L_ENST00000442598 RAD54L Q92698 DNA repair and recombination protein RAD54-like chr1 GO:0003697 Not Cancer Driver No 79 0.106 124 13 0.105 0
RADX RADX Q6NSI4 RPA-related protein RADX chrX GO:0003697 Not Cancer Driver No 141 0.165 226 35 0.155 0
RBBP8_ENST00000327155 RBBP8 Q99708 DNA endonuclease RBBP8 chr18 GO:0003697 Not Cancer Driver No 99 0.11 750 76 0.101 1
RBMS1 RBMS1 P29558 RNA-binding motif, single-stranded-interacting protein 1 chr2 GO:0003697 Not Cancer Driver No 55 0.135 243 36 0.148 0
RECQL4 RECQL4 O94761 ATP-dependent DNA helicase Q4 chr8 GO:0003697 Census, Compendium Yes 138 0.114 608 71 0.117 1
RECQL_ENST00000421138 RECQL P46063 ATP-dependent DNA helicase Q1 chr12 GO:0003697 Not Cancer Driver No 67 0.103 91 5 0.055 0
REXO4 REXO4 Q9GZR2 RNA exonuclease 4 chr9 GO:0003697 Not Cancer Driver No 34 0.081 298 26 0.087 0
RNF138 RNF138 Q8WVD3 E3 ubiquitin-protein ligase RNF138 chr18 GO:0003697 Not Cancer Driver No 44 0.18 34 6 0.176 0
RPA1 RPA1 P27694 Replication protein A 70 kDa DNA-binding subunit chr17 GO:0003697 Not Cancer Driver No 51 0.083 98 6 0.061 0
RPA2_ENST00000373912 RPA2 P15927 Replication protein A 32 kDa subunit chr1 GO:0003697 Not Cancer Driver No 28 0.104 114 16 0.14 0
RPA3 RPA3 P35244 Replication protein A 14 kDa subunit chr7 GO:0003697 Not Cancer Driver No 13 0.107 4 1 0.25 0
RPA4 RPA4 Q13156 Replication protein A 30 kDa subunit chrX GO:0003697 Not Cancer Driver No 66 0.253 58 15 0.259 0
RTF1 RTF1 Q92541 RNA polymerase-associated protein RTF1 homolog chr15 GO:0003697 Not Cancer Driver No 83 0.117 568 67 0.118 0
SAMHD1 SAMHD1 Q9Y3Z3 Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 chr20 GO:0003697 Not Cancer Driver No 104 0.166 91 14 0.154 13
SETMAR SETMAR Q53H47 Histone-lysine N-methyltransferase SETMAR chr3 GO:0003697 Not Cancer Driver No 62 0.091 154 12 0.078 0
SHOC1_ENST00000318737 SHOC1 Q5VXU9 Protein shortage in chiasmata 1 ortholog chr9 GO:0003697 Not Cancer Driver No 178 0.123 239 32 0.134 0
SMARCA1_ENST00000371122 SMARCA1 P28370 Probable global transcription activator SNF2L1 chrX GO:0003697 Compendium Yes 143 0.136 309 41 0.133 0
SMARCAL1 SMARCAL1 Q9NZC9 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A-like protein 1 chr2 GO:0003697 Not Cancer Driver No 128 0.134 335 49 0.146 11
SMC2 SMC2 O95347 Structural maintenance of chromosomes protein 2 chr9 GO:0003697 Not Cancer Driver No 145 0.121 573 88 0.154 0
SMC4_ENST00000344722 SMC4 Q9NTJ3 Structural maintenance of chromosomes protein 4 chr3 GO:0003697 Not Cancer Driver No 175 0.136 539 55 0.102 0
SMC6_ENST00000351948 SMC6 Q96SB8 Structural maintenance of chromosomes protein 6 chr2 GO:0003697 Not Cancer Driver No 128 0.117 458 57 0.124 0
SPRTN SPRTN Q9H040 DNA-dependent metalloprotease SPRTN chr1 GO:0003697 Not Cancer Driver No 73 0.149 252 38 0.151 1
SSBP1_ENST00000484178 SSBP1 Q04837 Single-stranded DNA-binding protein, mitochondrial chr7 GO:0003697 Not Cancer Driver No 27 0.182 0 0 0.0 6
SSBP2_ENST00000320672 SSBP2 P81877 Single-stranded DNA-binding protein 2 chr5 GO:0003697 Not Cancer Driver No 36 0.1 296 29 0.098 0
SSBP3 SSBP3 Q9BWW4 Single-stranded DNA-binding protein 3 chr1 GO:0003697 Not Cancer Driver No 51 0.131 321 42 0.131 0
SSBP4 SSBP4 Q9BWG4 Single-stranded DNA-binding protein 4 chr19 GO:0003697 Not Cancer Driver No 32 0.083 316 21 0.066 0
STN1 STN1 Q9H668 CST complex subunit STN1 chr10 GO:0003697 Not Cancer Driver No 41 0.111 27 2 0.074 2
SUB1_ENST00000515355 SUB1 P53999 Activated RNA polymerase II transcriptional coactivator p15 chr5 GO:0003697 Not Cancer Driver No 13 0.102 108 6 0.056 0
SWSAP1 SWSAP1 Q6NVH7 ATPase SWSAP1 chr19 GO:0003697 Not Cancer Driver No 26 0.114 104 14 0.135 0
TDP1_ENST00000393454 TDP1 Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 chr14 GO:0003697 Not Cancer Driver No 81 0.133 179 25 0.14 1
TDP2 TDP2 O95551 Tyrosyl-DNA phosphodiesterase 2 chr6 GO:0003697 Not Cancer Driver No 55 0.152 80 10 0.125 0
TEN1 TEN1 Q86WV5 CST complex subunit TEN1 chr17 GO:0003697 Not Cancer Driver No 6 0.049 8 4 0.5 0
TERF1 TERF1 P54274 Telomeric repeat-binding factor 1 chr8 GO:0003697 Not Cancer Driver No 63 0.144 220 34 0.155 0
TERF2 TERF2 Q15554 Telomeric repeat-binding factor 2 chr16 GO:0003697 Not Cancer Driver No 33 0.061 361 20 0.055 0
TERF2IP TERF2IP Q9NYB0 Telomeric repeat-binding factor 2-interacting protein 1 chr16 GO:0003697 Not Cancer Driver No 28 0.07 310 16 0.052 0
TOP1 TOP1 P11387 DNA topoisomerase 1 chr20 GO:0003697 Census, Compendium Yes 93 0.122 391 53 0.136 0
TOP3A TOP3A Q13472 DNA topoisomerase 3-alpha chr17 GO:0003697 Not Cancer Driver No 103 0.103 293 31 0.106 2
TP53_ENST00000445888 TP53 P04637 Cellular tumor antigen p53 chr17 GO:0003697 Census, Compendium Yes 2891 7.356 282 1466 5.199 83
TREX1_ENST00000625293 TREX1 Q9NSU2 Three-prime repair exonuclease 1 chr3 GO:0003697 Not Cancer Driver No 26 0.083 98 10 0.102 18
TSN TSN Q15631 Translin chr2 GO:0003697 Not Cancer Driver No 30 0.132 0 0 0.0 0
TWNK TWNK Q96RR1 Twinkle mtDNA helicase chr10 GO:0003697 Not Cancer Driver No 95 0.139 135 11 0.081 38
WBP11 WBP11 Q9Y2W2 WW domain-binding protein 11 chr12 GO:0003697 Not Cancer Driver No 86 0.134 606 79 0.13 0
WDR48 WDR48 Q8TAF3 WD repeat-containing protein 48 chr3 GO:0003697 Not Cancer Driver No 61 0.09 125 19 0.152 0
XPC XPC Q01831 DNA repair protein complementing XP-C cells chr3 GO:0003697 Census, Compendium Yes 88 0.094 479 48 0.1 2
YBX1 YBX1 P67809 Y-box-binding protein 1 chr1 GO:0003697 Not Cancer Driver No 41 0.127 312 41 0.131 0
ZRANB3 ZRANB3 Q5FWF4 DNA annealing helicase and endonuclease ZRANB3 chr2 GO:0003697 Not Cancer Driver No 126 0.117 261 31 0.119 0