Filter in search result
Please select a valid state.

Total number of protein in "GO:0003684" GO term:  68

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
APEX1_ENST00000555414 APEX1 P27695 DNA-(apurinic or apyrimidinic site) endonuclease chr14 GO:0003684 Not Cancer Driver No 34 0.107 103 14 0.136 0
APTX_ENST00000379819 APTX Q7Z2E3 Aprataxin chr9 GO:0003684 Not Cancer Driver No 36 0.101 101 6 0.059 9
AUNIP_ENST00000374298 AUNIP Q9H7T9 Aurora kinase A and ninein-interacting protein chr1 GO:0003684 Not Cancer Driver No 23 0.064 341 21 0.062 0
BLM BLM P54132 Bloom syndrome protein chr15 GO:0003684 Census Yes 153 0.108 667 70 0.105 8
BRCA1_ENST00000357654 BRCA1 P38398 Breast cancer type 1 susceptibility protein chr17 GO:0003684 Census, Compendium Yes 224 0.12 1458 174 0.119 35
CREBBP CREBBP Q92793 CREB-binding protein chr16 GO:0003684 Census, Compendium Yes 412 0.169 1796 247 0.138 33
CRY2_ENST00000616080 CRY2 Q49AN0 Cryptochrome-2 chr11 GO:0003684 Not Cancer Driver No 72 0.121 100 12 0.12 0
CUL4B CUL4B Q13620 Cullin-4B chrX GO:0003684 Not Cancer Driver No 138 0.151 207 38 0.184 2
DCLRE1A DCLRE1A Q6PJP8 DNA cross-link repair 1A protein chr10 GO:0003684 Not Cancer Driver No 92 0.088 514 45 0.088 0
DCLRE1B DCLRE1B Q9H816 5' exonuclease Apollo chr1 GO:0003684 Not Cancer Driver No 65 0.122 127 17 0.134 0
DCLRE1C DCLRE1C Q96SD1 Protein artemis chr10 GO:0003684 Not Cancer Driver No 76 0.11 277 26 0.094 3
DDB1 DDB1 Q16531 DNA damage-binding protein 1 chr11 GO:0003684 Not Cancer Driver No 126 0.111 50 8 0.16 4
DDB2 DDB2 Q92466 DNA damage-binding protein 2 chr11 GO:0003684 Census, Compendium Yes 45 0.105 70 5 0.071 2
EP300 EP300 Q09472 Histone acetyltransferase p300 chr22 GO:0003684 Census, Compendium Yes 334 0.138 1790 196 0.109 1
ERCC1_ENST00000589165 ERCC1 P07992 DNA excision repair protein ERCC-1 chr19 GO:0003684 Not Cancer Driver No 42 0.141 105 14 0.133 1
ERCC2 ERCC2 P18074 General transcription and DNA repair factor IIH helicase subunit XPD chr19 GO:0003684 Census, Compendium Yes 150 0.197 5 0 0.0 35
ERCC3 ERCC3 P19447 General transcription and DNA repair factor IIH helicase subunit XPB chr2 GO:0003684 Census, Compendium Yes 92 0.118 208 22 0.106 2
ERCC4 ERCC4 Q92889 DNA repair endonuclease XPF chr16 GO:0003684 Census Yes 120 0.131 225 27 0.12 15
ERCC5 ERCC5 P28715 DNA excision repair protein ERCC-5 chr13 GO:0003684 Census Yes 175 0.148 816 121 0.148 6
FANCG FANCG O15287 Fanconi anemia group G protein chr9 GO:0003684 Census Yes 64 0.103 48 3 0.062 1
FEN1 FEN1 P39748 Flap endonuclease 1 chr11 GO:0003684 Census Yes 35 0.092 111 11 0.099 0
H2AFX H2AX P16104 Histone H2AX chr11 GO:0003684 Not Cancer Driver No 20 0.14 68 10 0.147 0
HMGB1_ENST00000405805 HMGB1 P09429 High mobility group protein B1 chr13 GO:0003684 Not Cancer Driver No 25 0.116 203 20 0.099 0
HMGB2 HMGB2 P26583 High mobility group protein B2 chr4 GO:0003684 Not Cancer Driver No 38 0.182 207 38 0.184 0
KDM4D_ENST00000610872 KDM4D Q6B0I6 Lysine-specific demethylase 4D chr11 GO:0003684 Not Cancer Driver No 78 0.149 215 33 0.153 0
MPG MPG P29372 DNA-3-methyladenine glycosylase chr16 GO:0003684 Not Cancer Driver No 35 0.117 141 21 0.149 0
MSH2 MSH2 P43246 DNA mismatch repair protein Msh2 chr2 GO:0003684 Census Yes 92 0.099 37 4 0.108 70
MSH3 MSH3 P20585 DNA mismatch repair protein Msh3 chr5 GO:0003684 Not Cancer Driver No 100 0.088 211 20 0.095 0
MSH6 MSH6 P52701 DNA mismatch repair protein Msh6 chr2 GO:0003684 Census Yes 154 0.113 386 41 0.106 6
MUTYH MUTYH Q9UIF7 Adenine DNA glycosylase chr1 GO:0003684 Census Yes 90 0.165 198 29 0.146 23
NBN NBN O60934 Nibrin chr8 GO:0003684 Census Yes 90 0.119 417 54 0.129 1
NEIL1_ENST00000564784 NEIL1 Q96FI4 Endonuclease 8-like 1 chr15 GO:0003684 Not Cancer Driver No 41 0.105 165 14 0.085 0
NEIL2 NEIL2 Q969S2 Endonuclease 8-like 2 chr8 GO:0003684 Not Cancer Driver No 31 0.093 145 14 0.097 0
NEIL3 NEIL3 Q8TAT5 Endonuclease 8-like 3 chr4 GO:0003684 Not Cancer Driver No 80 0.132 131 18 0.137 0
NTHL1 NTHL1 P78549 Endonuclease III-like protein 1 chr16 GO:0003684 Census Yes 38 0.122 147 18 0.122 0
OGG1_ENST00000344629 OGG1 O15527 N-glycosylase/DNA lyase chr3 GO:0003684 Not Cancer Driver No 37 0.107 71 12 0.169 0
PCNA PCNA P12004 Proliferating cell nuclear antigen chr20 GO:0003684 Not Cancer Driver No 30 0.115 22 3 0.136 1
PNKP PNKP Q96T60 Bifunctional polynucleotide phosphatase/kinase chr19 GO:0003684 Not Cancer Driver No 53 0.102 177 23 0.13 4
POLB POLB P06746 DNA polymerase beta chr8 GO:0003684 Not Cancer Driver No 43 0.128 87 11 0.126 0
POLD1_ENST00000440232 POLD1 P28340 DNA polymerase delta catalytic subunit chr19 GO:0003684 Census, Compendium Yes 179 0.162 214 31 0.145 2
POLH POLH Q9Y253 DNA polymerase eta chr6 GO:0003684 Not Cancer Driver No 72 0.101 291 20 0.069 10
POLI POLI Q9UNA4 DNA polymerase iota chr18 GO:0003684 Not Cancer Driver No 82 0.111 300 32 0.107 0
POLK POLK Q9UBT6 DNA polymerase kappa chr5 GO:0003684 Not Cancer Driver No 97 0.111 293 36 0.123 0
POLQ POLQ O75417 DNA polymerase theta chr3 GO:0003684 Census, Compendium Yes 364 0.141 949 135 0.142 0
POT1 POT1 Q9NUX5 Protection of telomeres protein 1 chr7 GO:0003684 Census, Compendium Yes 113 0.178 31 6 0.194 9
RAD1 RAD1 O60671 Cell cycle checkpoint protein RAD1 chr5 GO:0003684 Not Cancer Driver No 29 0.103 4 1 0.25 0
RAD18 RAD18 Q9NS91 E3 ubiquitin-protein ligase RAD18 chr3 GO:0003684 Not Cancer Driver No 59 0.119 328 43 0.131 0
RAD23A RAD23A P54725 UV excision repair protein RAD23 homolog A chr19 GO:0003684 Not Cancer Driver No 50 0.138 283 41 0.145 0
RAD23B RAD23B P54727 UV excision repair protein RAD23 homolog B chr9 GO:0003684 Not Cancer Driver No 54 0.132 324 41 0.127 0
RBBP8_ENST00000327155 RBBP8 Q99708 DNA endonuclease RBBP8 chr18 GO:0003684 Not Cancer Driver No 99 0.11 750 76 0.101 1
RECQL4 RECQL4 O94761 ATP-dependent DNA helicase Q4 chr8 GO:0003684 Census, Compendium Yes 138 0.114 608 71 0.117 1
REV1 REV1 Q9UBZ9 DNA repair protein REV1 chr2 GO:0003684 Not Cancer Driver No 122 0.098 660 67 0.102 0
RPA1 RPA1 P27694 Replication protein A 70 kDa DNA-binding subunit chr17 GO:0003684 Not Cancer Driver No 51 0.083 98 6 0.061 0
RPA2_ENST00000373912 RPA2 P15927 Replication protein A 32 kDa subunit chr1 GO:0003684 Not Cancer Driver No 28 0.104 114 16 0.14 0
RPA3 RPA3 P35244 Replication protein A 14 kDa subunit chr7 GO:0003684 Not Cancer Driver No 13 0.107 4 1 0.25 0
RPS3_ENST00000527446 RPS3 P23396 40S ribosomal protein S3 chr11 GO:0003684 Not Cancer Driver No 22 0.091 48 4 0.083 0
SDE2 SDE2 Q6IQ49 Replication stress response regulator SDE2 chr1 GO:0003684 Not Cancer Driver No 56 0.124 290 35 0.121 0
SMC6_ENST00000351948 SMC6 Q96SB8 Structural maintenance of chromosomes protein 6 chr2 GO:0003684 Not Cancer Driver No 128 0.117 458 57 0.124 0
TDG TDG Q13569 G/T mismatch-specific thymine DNA glycosylase chr12 GO:0003684 Not Cancer Driver No 75 0.183 185 31 0.168 0
TP53BP1_ENST00000263801 TP53BP1 Q12888 TP53-binding protein 1 chr15 GO:0003684 Not Cancer Driver No 227 0.115 1632 190 0.116 0
TP63 TP63 Q9H3D4 Tumor protein 63 chr3 GO:0003684 Census, Compendium Yes 229 0.337 398 143 0.359 28
UNG UNG P13051 Uracil-DNA glycosylase chr12 GO:0003684 Not Cancer Driver No 34 0.109 96 13 0.135 1
WRN WRN Q14191 Werner syndrome ATP-dependent helicase chr8 GO:0003684 Census, Compendium Yes 164 0.115 373 41 0.11 2
XPA XPA P23025 DNA repair protein complementing XP-A cells chr9 GO:0003684 Census Yes 27 0.099 121 13 0.107 5
XPC XPC Q01831 DNA repair protein complementing XP-C cells chr3 GO:0003684 Census, Compendium Yes 88 0.094 479 48 0.1 2
XRCC1 XRCC1 P18887 DNA repair protein XRCC1 chr19 GO:0003684 Not Cancer Driver No 85 0.134 426 53 0.124 1
XRCC5_ENST00000392132 XRCC5 P13010 X-ray repair cross-complementing protein 5 chr2 GO:0003684 Not Cancer Driver No 87 0.119 118 11 0.093 0
XRCC6 XRCC6 P12956 X-ray repair cross-complementing protein 6 chr22 GO:0003684 Not Cancer Driver No 66 0.108 140 12 0.086 0