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Total number of protein in "GO:0003013" GO term:  238

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ABCA2_ENST00000371605 ABCA2 Q9BZC7 ATP-binding cassette sub-family A member 2 chr9 GO:0003013 Not Cancer Driver No 240 0.099 497 44 0.089 0
ABCB1_ENST00000265724 ABCB1 P08183 ATP-dependent translocase ABCB1 chr7 GO:0003013 Compendium Yes 367 0.287 103 31 0.301 0
ABCC1 ABCC1 P33527 Multidrug resistance-associated protein 1 chr16 GO:0003013 Not Cancer Driver No 199 0.13 123 22 0.179 1
ABCC2 ABCC2 Q92887 ATP-binding cassette sub-family C member 2 chr10 GO:0003013 Not Cancer Driver No 202 0.131 102 23 0.225 4
ABCC3 ABCC3 O15438 ATP-binding cassette sub-family C member 3 chr17 GO:0003013 Not Cancer Driver No 210 0.138 113 19 0.168 0
ABCC4_ENST00000376887 ABCC4 O15439 ATP-binding cassette sub-family C member 4 chr13 GO:0003013 Not Cancer Driver No 174 0.131 97 6 0.062 0
ABCC5 ABCC5 O15440 ATP-binding cassette sub-family C member 5 chr3 GO:0003013 Not Cancer Driver No 191 0.133 255 29 0.114 0
ABCC8_ENST00000389817 ABCC8 Q09428 ATP-binding cassette sub-family C member 8 chr11 GO:0003013 Not Cancer Driver No 255 0.161 138 23 0.167 97
ABCC9_ENST00000261201 ABCC9 O60706 ATP-binding cassette sub-family C member 9 chr12 GO:0003013 Not Cancer Driver No 368 0.238 132 30 0.227 15
ABCG2 ABCG2 Q9UNQ0 Broad substrate specificity ATP-binding cassette transporter ABCG2 chr4 GO:0003013 Not Cancer Driver No 124 0.189 35 10 0.286 0
ABL1_ENST00000318560 ABL1 P00519 Tyrosine-protein kinase ABL1 chr9 GO:0003013 Census, Compendium Yes 139 0.123 604 73 0.121 2
ACE ACE P12821 Angiotensin-converting enzyme chr17 GO:0003013 Not Cancer Driver No 201 0.154 86 8 0.093 0
ACE2 ACE2 Q9BYF1 Angiotensin-converting enzyme 2 chrX GO:0003013 Not Cancer Driver No 104 0.129 68 5 0.074 0
ACTA2 ACTA2 P62736 Actin, aortic smooth muscle chr10 GO:0003013 Not Cancer Driver No 50 0.133 39 4 0.103 17
ADM ADM P35318 Pro-adrenomedullin chr11 GO:0003013 Not Cancer Driver No 20 0.108 113 13 0.115 0
ADORA2A ADORA2A P29274 Adenosine receptor A2a chr22 GO:0003013 Not Cancer Driver No 61 0.148 93 11 0.118 0
ADORA2B ADORA2B P29275 Adenosine receptor A2b chr17 GO:0003013 Not Cancer Driver No 23 0.069 0 0 0.0 0
ADRA1A_ENST00000380573 ADRA1A P35348 Alpha-1A adrenergic receptor chr8 GO:0003013 Not Cancer Driver No 130 0.279 40 8 0.2 0
ADRA1B ADRA1B P35368 Alpha-1B adrenergic receptor chr5 GO:0003013 Not Cancer Driver No 53 0.102 132 1 0.008 0
ADRA1D ADRA1D P25100 Alpha-1D adrenergic receptor chr20 GO:0003013 Not Cancer Driver No 62 0.108 189 19 0.101 0
ADRA2A ADRA2A P08913 Alpha-2A adrenergic receptor chr10 GO:0003013 Not Cancer Driver No 67 0.144 161 10 0.062 0
ADRA2B ADRA2B P18089 Alpha-2B adrenergic receptor chr2 GO:0003013 Not Cancer Driver No 73 0.162 136 20 0.147 0
ADRA2C ADRA2C P18825 Alpha-2C adrenergic receptor chr4 GO:0003013 Not Cancer Driver No 47 0.102 107 0 0.0 0
ADRB1 ADRB1 P08588 Beta-1 adrenergic receptor chr10 GO:0003013 Not Cancer Driver No 35 0.073 116 1 0.009 0
ADRB2 ADRB2 P07550 Beta-2 adrenergic receptor chr5 GO:0003013 Not Cancer Driver No 52 0.126 35 4 0.114 0
ADRB3 ADRB3 P13945 Beta-3 adrenergic receptor chr8 GO:0003013 Not Cancer Driver No 40 0.098 44 6 0.136 0
AGER_ENST00000375076 AGER Q15109 Advanced glycosylation end product-specific receptor chr6 GO:0003013 Not Cancer Driver No 31 0.077 297 21 0.071 0
AGT AGT P01019 Angiotensinogen chr1 GO:0003013 Not Cancer Driver No 85 0.179 33 10 0.303 1
AGTR1_ENST00000349243 AGTR1 P30556 Type-1 angiotensin II receptor chr3 GO:0003013 Not Cancer Driver No 95 0.265 0 0 0.0 1
AGTR2 AGTR2 P50052 Type-2 angiotensin II receptor chrX GO:0003013 Not Cancer Driver No 98 0.27 0 0 0.0 0
AKAP12 AKAP12 Q02952 A-kinase anchor protein 12 chr6 GO:0003013 Not Cancer Driver No 215 0.121 1770 214 0.121 0
ANGPT1 ANGPT1 Q15389 Angiopoietin-1 chr8 GO:0003013 Not Cancer Driver No 130 0.261 131 24 0.183 1
APOE APOE P02649 Apolipoprotein E chr19 GO:0003013 Not Cancer Driver No 25 0.079 124 6 0.048 12
ARHGAP35_ENST00000614079 ARHGAP35 Q9NRY4 Rho GTPase-activating protein 35 chr19 GO:0003013 Census, Compendium Yes 255 0.17 409 58 0.142 0
ARHGAP42 ARHGAP42 A6NI28 Rho GTPase-activating protein 42 chr11 GO:0003013 Not Cancer Driver No 63 0.072 311 17 0.055 0
ASIC2_ENST00000359872 ASIC2 Q16515 Acid-sensing ion channel 2 chr17 GO:0003013 Not Cancer Driver No 101 0.197 49 1 0.02 0
ATG5_ENST00000343245 ATG5 Q9H1Y0 Autophagy protein 5 chr6 GO:0003013 Not Cancer Driver No 40 0.145 25 6 0.24 1
ATP1A2 ATP1A2 P50993 Sodium/potassium-transporting ATPase subunit alpha-2 chr1 GO:0003013 Not Cancer Driver No 230 0.225 161 34 0.211 8
ATP1A4 ATP1A4 Q13733 Sodium/potassium-transporting ATPase subunit alpha-4 chr1 GO:0003013 Not Cancer Driver No 195 0.19 117 24 0.205 0
ATP1B2 ATP1B2 P14415 Sodium/potassium-transporting ATPase subunit beta-2 chr17 GO:0003013 Not Cancer Driver No 40 0.138 16 6 0.375 0
ATP2A3_ENST00000397041 ATP2A3 Q93084 Sarcoplasmic/endoplasmic reticulum calcium ATPase 3 chr17 GO:0003013 Not Cancer Driver No 130 0.13 147 16 0.109 0
ATP2B1_ENST00000261173 ATP2B1 P20020 Plasma membrane calcium-transporting ATPase 1 chr12 GO:0003013 Not Cancer Driver No 143 0.117 293 42 0.143 0
ATP8A1 ATP8A1 Q9Y2Q0 Phospholipid-transporting ATPase IA chr4 GO:0003013 Not Cancer Driver No 185 0.159 84 7 0.083 0
AVP AVP P01185 Vasopressin-neurophysin 2-copeptin chr20 GO:0003013 Not Cancer Driver No 14 0.085 26 0 0.0 39
AVPR1A AVPR1A P37288 Vasopressin V1a receptor chr12 GO:0003013 Not Cancer Driver No 105 0.251 68 25 0.368 0
AVPR1B AVPR1B P47901 Vasopressin V1b receptor chr1 GO:0003013 Not Cancer Driver No 83 0.196 51 5 0.098 0
AVPR2_ENST00000337474 AVPR2 P30518 Vasopressin V2 receptor chrX GO:0003013 Not Cancer Driver No 58 0.156 56 7 0.125 84
AZU1 AZU1 P20160 Azurocidin chr19 GO:0003013 Not Cancer Driver No 42 0.167 53 13 0.245 0
BCR BCR P11274 Breakpoint cluster region protein chr22 GO:0003013 Census, Compendium Yes 146 0.115 603 69 0.114 0
BDKRB2 BDKRB2 P30411 B2 bradykinin receptor chr14 GO:0003013 Not Cancer Driver No 81 0.207 0 0 0.0 0
BMP6 BMP6 P22004 Bone morphogenetic protein 6 chr6 GO:0003013 Not Cancer Driver No 95 0.185 226 51 0.226 0
BMPR2 BMPR2 Q13873 Bone morphogenetic protein receptor type-2 chr2 GO:0003013 Compendium Yes 141 0.136 601 70 0.116 19
C2CD4A C2CD4A Q8NCU7 C2 calcium-dependent domain-containing protein 4A chr15 GO:0003013 Not Cancer Driver No 13 0.035 223 4 0.018 0
C2CD4B C2CD4B A6NLJ0 C2 calcium-dependent domain-containing protein 4B chr15 GO:0003013 Not Cancer Driver No 5 0.014 191 0 0.0 0
CASR_ENST00000638421 CASR P41180 Extracellular calcium-sensing receptor chr3 GO:0003013 Not Cancer Driver No 304 0.282 189 60 0.317 108
CAV1 CAV1 Q03135 Caveolin-1 chr7 GO:0003013 Not Cancer Driver No 30 0.169 2 0 0.0 0
CD36_ENST00000309881 CD36 P16671 Platelet glycoprotein 4 chr7 GO:0003013 Not Cancer Driver No 75 0.159 12 3 0.25 3
CD38 CD38 P28907 ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 chr4 GO:0003013 Not Cancer Driver No 54 0.18 3 1 0.333 0
CDH5 CDH5 P33151 Cadherin-5 chr16 GO:0003013 Not Cancer Driver No 144 0.184 305 55 0.18 0
CEACAM1 CEACAM1 P13688 Carcinoembryonic antigen-related cell adhesion molecule 1 chr19 GO:0003013 Not Cancer Driver No 64 0.122 241 25 0.104 0
CHRM3_ENST00000615928 CHRM3 P20309 Muscarinic acetylcholine receptor M3 chr1 GO:0003013 Not Cancer Driver No 182 0.308 136 42 0.309 0
CLDN5_ENST00000618236 CLDN5 O00501 Claudin-5 chr22 GO:0003013 Not Cancer Driver No 15 0.069 0 0 0.0 0
COMP COMP P49747 Cartilage oligomeric matrix protein chr19 GO:0003013 Not Cancer Driver No 97 0.128 306 52 0.17 61
CPS1_ENST00000233072 CPS1 P31327 Carbamoyl-phosphate synthase [ammonia], mitochondrial chr2 GO:0003013 Not Cancer Driver No 368 0.245 73 22 0.301 140
CRP CRP P02741 C-reactive protein chr1 GO:0003013 Not Cancer Driver No 59 0.263 0 0 0.0 0
CTNNBIP1_ENST00000377258 CTNNBIP1 Q9NSA3 Beta-catenin-interacting protein 1 chr1 GO:0003013 Not Cancer Driver No 8 0.099 64 7 0.109 0
CYSLTR1 CYSLTR1 Q9Y271 Cysteinyl leukotriene receptor 1 chrX GO:0003013 Not Cancer Driver No 58 0.172 8 1 0.125 0
DBH DBH P09172 Dopamine beta-hydroxylase chr9 GO:0003013 Not Cancer Driver No 125 0.203 71 17 0.239 3
DDAH1 DDAH1 O94760 N(G),N(G)-dimethylarginine dimethylaminohydrolase 1 chr1 GO:0003013 Not Cancer Driver No 28 0.098 44 3 0.068 0
DOCK4 DOCK4 Q8N1I0 Dedicator of cytokinesis protein 4 chr7 GO:0003013 Not Cancer Driver No 331 0.168 397 80 0.202 0
DOCK5 DOCK5 Q9H7D0 Dedicator of cytokinesis protein 5 chr8 GO:0003013 Not Cancer Driver No 278 0.149 330 45 0.136 0
DRD1 DRD1 P21728 D(1A) dopamine receptor chr5 GO:0003013 Not Cancer Driver No 73 0.164 30 4 0.133 0
DRD5 DRD5 P21918 D(1B) dopamine receptor chr4 GO:0003013 Not Cancer Driver No 172 0.361 29 18 0.621 0
ECE1 ECE1 P42892 Endothelin-converting enzyme 1 chr1 GO:0003013 Not Cancer Driver No 118 0.153 99 26 0.263 1
EDN1 EDN1 P05305 Endothelin-1 chr6 GO:0003013 Not Cancer Driver No 37 0.175 97 20 0.206 3
EDN2 EDN2 P20800 Endothelin-2 chr1 GO:0003013 Not Cancer Driver No 21 0.118 87 13 0.149 0
EDN3_ENST00000371028 EDN3 P14138 Endothelin-3 chr20 GO:0003013 Not Cancer Driver No 69 0.29 140 44 0.314 3
EDNRA EDNRA P25101 Endothelin-1 receptor chr4 GO:0003013 Not Cancer Driver No 62 0.145 21 6 0.286 2
EDNRB_ENST00000334286 EDNRB P24530 Endothelin receptor type B chr13 GO:0003013 Not Cancer Driver No 112 0.253 56 19 0.339 6
EXT1 EXT1 Q16394 Exostosin-1 chr8 GO:0003013 Census Yes 107 0.143 58 7 0.121 12
EXT2_ENST00000533608 EXT2 Q93063 Exostosin-2 chr11 GO:0003013 Census, Compendium Yes 93 0.13 12 1 0.083 9
F2R F2R P25116 Proteinase-activated receptor 1 chr5 GO:0003013 Not Cancer Driver No 73 0.172 19 2 0.105 0
F2RL1 F2RL1 P55085 Proteinase-activated receptor 2 chr5 GO:0003013 Not Cancer Driver No 55 0.139 7 2 0.286 0
FAAH FAAH O00519 Fatty-acid amide hydrolase 1 chr1 GO:0003013 Not Cancer Driver No 63 0.109 50 14 0.28 0
FABP5 FABP5 Q01469 Fatty acid-binding protein 5 chr8 GO:0003013 Not Cancer Driver No 15 0.111 4 4 1.0 0
FERMT2_ENST00000395631 FERMT2 Q96AC1 Fermitin family homolog 2 chr14 GO:0003013 Not Cancer Driver No 71 0.104 101 10 0.099 0
FGA FGA P02671 Fibrinogen alpha chain chr4 GO:0003013 Not Cancer Driver No 245 0.283 522 149 0.285 7
FGB FGB P02675 Fibrinogen beta chain chr4 GO:0003013 Not Cancer Driver No 89 0.181 143 29 0.203 7
FGFBP3 FGFBP3 Q8TAT2 Fibroblast growth factor-binding protein 3 chr10 GO:0003013 Not Cancer Driver No 6 0.023 175 3 0.017 0
FGG FGG P02679 Fibrinogen gamma chain chr4 GO:0003013 Not Cancer Driver No 81 0.179 53 8 0.151 8
GCH1_ENST00000622544 GCH1 P30793 GTP cyclohydrolase 1 chr14 GO:0003013 Not Cancer Driver No 20 0.08 99 5 0.051 38
GJA5 GJA5 P36382 Gap junction alpha-5 protein chr1 GO:0003013 Not Cancer Driver No 74 0.207 92 21 0.228 5
GPER1 GPER1 Q99527 G-protein coupled estrogen receptor 1 chr7 GO:0003013 Not Cancer Driver No 65 0.173 13 5 0.385 0
GPR4 GPR4 P46093 G-protein coupled receptor 4 chr19 GO:0003013 Not Cancer Driver No 57 0.157 44 8 0.182 0
GPX1_ENST00000620890 GPX1 P07203 Glutathione peroxidase 1 chr3 GO:0003013 Not Cancer Driver No 38 0.187 12 1 0.083 0
GRIP2_ENST00000621039 GRIP2 Q9C0E4 Glutamate receptor-interacting protein 2 chr3 GO:0003013 Not Cancer Driver No 143 0.137 586 84 0.143 0
HEG1 HEG1 Q9ULI3 Protein HEG homolog 1 chr3 GO:0003013 Not Cancer Driver No 173 0.125 974 135 0.139 0
HRH1_ENST00000438284 HRH1 P35367 Histamine H1 receptor chr3 GO:0003013 Not Cancer Driver No 96 0.197 122 26 0.213 0
HRH2_ENST00000231683 HRH2 P25021 Histamine H2 receptor chr5 GO:0003013 Not Cancer Driver No 84 0.234 44 6 0.136 0
HTR1A HTR1A P08908 5-hydroxytryptamine receptor 1A chr5 GO:0003013 Not Cancer Driver No 170 0.403 100 49 0.49 0
HTR1B HTR1B P28222 5-hydroxytryptamine receptor 1B chr6 GO:0003013 Not Cancer Driver No 91 0.233 33 15 0.455 0
HTR1D HTR1D P28221 5-hydroxytryptamine receptor 1D chr1 GO:0003013 Not Cancer Driver No 54 0.143 24 1 0.042 0
HTR2A HTR2A P28223 5-hydroxytryptamine receptor 2A chr13 GO:0003013 Not Cancer Driver No 105 0.223 44 8 0.182 0
HTR2B HTR2B P41595 5-hydroxytryptamine receptor 2B chr2 GO:0003013 Not Cancer Driver No 41 0.085 23 2 0.087 0
HTR7 HTR7 P34969 5-hydroxytryptamine receptor 7 chr10 GO:0003013 Not Cancer Driver No 102 0.213 24 1 0.042 0
INS INS P01308 Insulin chr11 GO:0003013 Not Cancer Driver No 15 0.136 5 1 0.2 22
INSR INSR P06213 Insulin receptor chr19 GO:0003013 Not Cancer Driver No 190 0.137 280 57 0.204 64
ITGA1 ITGA1 P56199 Integrin alpha-1 chr5 GO:0003013 Not Cancer Driver No 156 0.132 107 13 0.121 0
KCNA5 KCNA5 P22460 Potassium voltage-gated channel subfamily A member 5 chr12 GO:0003013 Not Cancer Driver No 213 0.347 218 53 0.243 0
KCNJ8 KCNJ8 Q15842 ATP-sensitive inward rectifier potassium channel 8 chr12 GO:0003013 Not Cancer Driver No 99 0.233 68 22 0.324 1
KCNMB1 KCNMB1 Q16558 Calcium-activated potassium channel subunit beta-1 chr5 GO:0003013 Not Cancer Driver No 49 0.257 0 0 0.0 0
KCNMB2_ENST00000452583 KCNMB2 Q9Y691 Calcium-activated potassium channel subunit beta-2 chr3 GO:0003013 Not Cancer Driver No 61 0.26 0 0 0.0 0
KCNMB4 KCNMB4 Q86W47 Calcium-activated potassium channel subunit beta-4 chr12 GO:0003013 Not Cancer Driver No 41 0.195 0 0 0.0 0
KEL KEL P23276 Kell blood group glycoprotein chr7 GO:0003013 Compendium Yes 232 0.317 117 39 0.333 0
KLF2 KLF2 Q9Y5W3 Krueppel-like factor 2 chr19 GO:0003013 Not Cancer Driver No 13 0.037 280 4 0.014 0
KNG1 KNG1 P01042 Kininogen-1 chr3 GO:0003013 Not Cancer Driver No 130 0.202 294 66 0.224 1
LEP LEP P41159 Leptin chr7 GO:0003013 Not Cancer Driver No 29 0.174 0 0 0.0 2
LEPR LEPR P48357 Leptin receptor chr1 GO:0003013 Not Cancer Driver No 243 0.209 57 11 0.193 0
LRP1 LRP1 Q07954 Prolow-density lipoprotein receptor-related protein 1 chr12 GO:0003013 Not Cancer Driver No 664 0.146 317 52 0.164 1
LRP2 LRP2 P98164 Low-density lipoprotein receptor-related protein 2 chr2 GO:0003013 Not Cancer Driver No 998 0.214 209 40 0.191 1
LRP3 LRP3 O75074 Low-density lipoprotein receptor-related protein 3 chr19 GO:0003013 Not Cancer Driver No 88 0.114 214 20 0.093 0
MFSD2A MFSD2A Q8NA29 Sodium-dependent lysophosphatidylcholine symporter 1 chr1 GO:0003013 Not Cancer Driver No 61 0.112 36 4 0.111 7
MKKS MKKS Q9NPJ1 McKusick-Kaufman/Bardet-Biedl syndromes putative chaperonin chr20 GO:0003013 Not Cancer Driver No 56 0.098 6 1 0.167 22
MMP2 MMP2 P08253 72 kDa type IV collagenase chr16 GO:0003013 Not Cancer Driver No 123 0.186 29 6 0.207 2
MTNR1B MTNR1B P49286 Melatonin receptor type 1B chr11 GO:0003013 Not Cancer Driver No 104 0.287 8 1 0.125 0
MYLK3 MYLK3 Q32MK0 Myosin light chain kinase 3 chr16 GO:0003013 Not Cancer Driver No 163 0.199 469 83 0.177 0
NOS1_ENST00000317775 NOS1 P29475 Nitric oxide synthase, brain chr12 GO:0003013 Not Cancer Driver No 405 0.282 342 99 0.289 0
NOS3 NOS3 P29474 Nitric oxide synthase, endothelial chr7 GO:0003013 Not Cancer Driver No 168 0.14 347 38 0.11 0
NPPA NPPA P01160 Natriuretic peptides A chr1 GO:0003013 Not Cancer Driver No 32 0.212 71 14 0.197 1
NPPB NPPB P16860 Natriuretic peptides B chr1 GO:0003013 Not Cancer Driver No 31 0.231 104 28 0.269 0
NPR1 NPR1 P16066 Atrial natriuretic peptide receptor 1 chr1 GO:0003013 Not Cancer Driver No 141 0.133 78 16 0.205 0
NPR3 NPR3 P17342 Atrial natriuretic peptide receptor 3 chr5 GO:0003013 Not Cancer Driver No 95 0.176 58 8 0.138 0
OCLN OCLN Q16625 Occludin chr5 GO:0003013 Not Cancer Driver No 54 0.103 244 21 0.086 1
OXTR OXTR P30559 Oxytocin receptor chr3 GO:0003013 Not Cancer Driver No 46 0.118 18 0 0.0 0
P2RX1 P2RX1 P51575 P2X purinoceptor 1 chr17 GO:0003013 Not Cancer Driver No 59 0.148 14 1 0.071 0
PDE2A PDE2A O00408 cGMP-dependent 3',5'-cyclic phosphodiesterase chr11 GO:0003013 Not Cancer Driver No 137 0.146 99 7 0.071 0
PDE3A PDE3A Q14432 cGMP-inhibited 3',5'-cyclic phosphodiesterase A chr12 GO:0003013 Not Cancer Driver No 274 0.24 527 114 0.216 6
PER2 PER2 O15055 Period circadian protein homolog 2 chr2 GO:0003013 Not Cancer Driver No 166 0.132 782 101 0.129 1
PIK3C2A PIK3C2A O00443 Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit alpha chr11 GO:0003013 Not Cancer Driver No 187 0.111 350 43 0.123 0
PLA2G6 PLA2G6 O60733 85/88 kDa calcium-independent phospholipase A2 chr22 GO:0003013 Not Cancer Driver No 108 0.134 148 23 0.155 11
PLEC PLEC Q15149 Plectin chr8 GO:0003013 Not Cancer Driver No 677 0.145 2130 272 0.128 2
PLOD3 PLOD3 O60568 Multifunctional procollagen lysine hydroxylase and glycosyltransferase LH3 chr7 GO:0003013 Not Cancer Driver No 108 0.146 65 8 0.123 1
PLVAP PLVAP Q9BX97 Plasmalemma vesicle-associated protein chr19 GO:0003013 Not Cancer Driver No 96 0.217 174 39 0.224 1
PPARD_ENST00000360694 PPARD Q03181 Peroxisome proliferator-activated receptor delta chr6 GO:0003013 Not Cancer Driver No 72 0.163 69 7 0.101 0
PTGS2 PTGS2 P35354 Prostaglandin G/H synthase 2 chr1 GO:0003013 Not Cancer Driver No 105 0.174 30 5 0.167 0
PTP4A3_ENST00000521578 PTP4A3 O75365 Protein tyrosine phosphatase type IVA 3 chr8 GO:0003013 Not Cancer Driver No 30 0.173 3 0 0.0 0
PTPRJ PTPRJ Q12913 Receptor-type tyrosine-protein phosphatase eta chr11 GO:0003013 Not Cancer Driver No 184 0.138 401 61 0.152 0
RAMP2 RAMP2 O60895 Receptor activity-modifying protein 2 chr17 GO:0003013 Not Cancer Driver No 18 0.103 34 6 0.176 0
RAP1GDS1_ENST00000408927 RAP1GDS1 P52306 Rap1 GTPase-GDP dissociation stimulator 1 chr4 GO:0003013 Census, Compendium Yes 93 0.153 13 0 0.0 0
RHOA RHOA P61586 Transforming protein RhoA chr3 GO:0003013 Census, Compendium Yes 99 0.513 46 13 0.283 2
SCNN1B SCNN1B P51168 Amiloride-sensitive sodium channel subunit beta chr16 GO:0003013 Not Cancer Driver No 90 0.141 62 4 0.065 13
SERPINF2_ENST00000382061 SERPINF2 P08697 Alpha-2-antiplasmin chr17 GO:0003013 Not Cancer Driver No 62 0.126 112 21 0.188 1
SH3GL2 SH3GL2 Q99962 Endophilin-A1 chr9 GO:0003013 Not Cancer Driver No 76 0.216 214 50 0.234 0
SLC12A2 SLC12A2 P55011 Solute carrier family 12 member 2 chr5 GO:0003013 Not Cancer Driver No 141 0.116 297 18 0.061 8
SLC13A3 SLC13A3 Q8WWT9 Solute carrier family 13 member 3 chr20 GO:0003013 Not Cancer Driver No 113 0.188 44 10 0.227 2
SLC15A2 SLC15A2 Q16348 Solute carrier family 15 member 2 chr3 GO:0003013 Not Cancer Driver No 153 0.21 37 7 0.189 0
SLC16A1 SLC16A1 P53985 Monocarboxylate transporter 1 chr1 GO:0003013 Not Cancer Driver No 69 0.138 70 3 0.043 3
SLC16A12 SLC16A12 Q6ZSM3 Monocarboxylate transporter 12 chr10 GO:0003013 Not Cancer Driver No 53 0.103 24 1 0.042 0
SLC16A2 SLC16A2 P36021 Monocarboxylate transporter 8 chrX GO:0003013 Not Cancer Driver No 84 0.156 124 12 0.097 20
SLC16A7 SLC16A7 O60669 Monocarboxylate transporter 2 chr12 GO:0003013 Not Cancer Driver No 85 0.178 77 12 0.156 0
SLC19A1 SLC19A1 P41440 Reduced folate transporter chr21 GO:0003013 Not Cancer Driver No 77 0.13 144 7 0.049 0
SLC1A1 SLC1A1 P43005 Excitatory amino acid transporter 3 chr9 GO:0003013 Not Cancer Driver No 69 0.132 17 4 0.235 1
SLC1A2 SLC1A2 P43004 Excitatory amino acid transporter 2 chr11 GO:0003013 Not Cancer Driver No 77 0.134 81 7 0.086 3
SLC1A3 SLC1A3 P43003 Excitatory amino acid transporter 1 chr5 GO:0003013 Not Cancer Driver No 100 0.185 55 9 0.164 1
SLC1A4 SLC1A4 P43007 Neutral amino acid transporter A chr2 GO:0003013 Not Cancer Driver No 43 0.081 90 9 0.1 2
SLC1A5 SLC1A5 Q15758 Neutral amino acid transporter B(0) chr19 GO:0003013 Not Cancer Driver No 52 0.096 61 7 0.115 0
SLC22A1 SLC22A1 O15245 Solute carrier family 22 member 1 chr6 GO:0003013 Not Cancer Driver No 68 0.123 12 0 0.0 0
SLC22A2 SLC22A2 O15244 Solute carrier family 22 member 2 chr6 GO:0003013 Not Cancer Driver No 126 0.227 31 11 0.355 0
SLC22A3 SLC22A3 O75751 Solute carrier family 22 member 3 chr6 GO:0003013 Not Cancer Driver No 73 0.131 21 1 0.048 0
SLC22A5_ENST00000245407 SLC22A5 O76082 Solute carrier family 22 member 5 chr5 GO:0003013 Not Cancer Driver No 53 0.095 15 2 0.133 73
SLC22A8 SLC22A8 Q8TCC7 Solute carrier family 22 member 8 chr11 GO:0003013 Not Cancer Driver No 104 0.192 64 17 0.266 0
SLC24A3 SLC24A3 Q9HC58 Sodium/potassium/calcium exchanger 3 chr20 GO:0003013 Not Cancer Driver No 143 0.222 120 45 0.375 0
SLC27A1 SLC27A1 Q6PCB7 Long-chain fatty acid transport protein 1 chr19 GO:0003013 Not Cancer Driver No 88 0.136 16 0 0.0 0
SLC27A4 SLC27A4 Q6P1M0 Long-chain fatty acid transport protein 4 chr9 GO:0003013 Not Cancer Driver No 83 0.129 27 3 0.111 5
SLC28A2 SLC28A2 O43868 Sodium/nucleoside cotransporter 2 chr15 GO:0003013 Not Cancer Driver No 93 0.141 36 6 0.167 0
SLC29A1_ENST00000371708 SLC29A1 Q99808 Equilibrative nucleoside transporter 1 chr6 GO:0003013 Not Cancer Driver No 51 0.112 27 4 0.148 0
SLC29A2_ENST00000544554 SLC29A2 Q14542 Equilibrative nucleoside transporter 2 chr11 GO:0003013 Not Cancer Driver No 60 0.132 30 6 0.2 0
SLC29A4_ENST00000297195 SLC29A4 Q7RTT9 Equilibrative nucleoside transporter 4 chr7 GO:0003013 Not Cancer Driver No 93 0.175 49 10 0.204 0
SLC2A1 SLC2A1 P11166 Solute carrier family 2, facilitated glucose transporter member 1 chr1 GO:0003013 Not Cancer Driver No 51 0.104 13 2 0.154 48
SLC2A10 SLC2A10 O95528 Solute carrier family 2, facilitated glucose transporter member 10 chr20 GO:0003013 Not Cancer Driver No 98 0.181 72 15 0.208 8
SLC2A13 SLC2A13 Q96QE2 Proton myo-inositol cotransporter chr12 GO:0003013 Not Cancer Driver No 79 0.122 52 4 0.077 0
SLC2A3 SLC2A3 P11169 Solute carrier family 2, facilitated glucose transporter member 3 chr12 GO:0003013 Not Cancer Driver No 96 0.194 33 11 0.333 0
SLC2A4 SLC2A4 P14672 Solute carrier family 2, facilitated glucose transporter member 4 chr17 GO:0003013 Not Cancer Driver No 71 0.139 43 8 0.186 1
SLC38A1_ENST00000546893 SLC38A1 Q9H2H9 Sodium-coupled neutral amino acid transporter 1 chr12 GO:0003013 Not Cancer Driver No 95 0.195 25 4 0.16 0
SLC38A2 SLC38A2 Q96QD8 Sodium-coupled neutral amino acid transporter 2 chr12 GO:0003013 Not Cancer Driver No 60 0.119 9 1 0.111 0
SLC38A3 SLC38A3 Q99624 Sodium-coupled neutral amino acid transporter 3 chr3 GO:0003013 Not Cancer Driver No 61 0.121 42 2 0.048 0
SLC38A5 SLC38A5 Q8WUX1 Sodium-coupled neutral amino acid transporter 5 chrX GO:0003013 Not Cancer Driver No 52 0.11 11 1 0.091 0
SLC44A1 SLC44A1 Q8WWI5 Choline transporter-like protein 1 chr9 GO:0003013 Not Cancer Driver No 75 0.114 2 0 0.0 0
SLC4A3_ENST00000317151 SLC4A3 P48751 Anion exchange protein 3 chr2 GO:0003013 Not Cancer Driver No 189 0.153 564 91 0.161 0
SLC4A4_ENST00000264485 SLC4A4 Q9Y6R1 Electrogenic sodium bicarbonate cotransporter 1 chr4 GO:0003013 Not Cancer Driver No 193 0.179 281 60 0.214 8
SLC4A8 SLC4A8 Q2Y0W8 Electroneutral sodium bicarbonate exchanger 1 chr12 GO:0003013 Not Cancer Driver No 176 0.161 276 41 0.149 0
SLC5A1 SLC5A1 P13866 Sodium/glucose cotransporter 1 chr22 GO:0003013 Not Cancer Driver No 104 0.157 47 2 0.043 22
SLC5A3 SLC5A3 P53794 Sodium/myo-inositol cotransporter chr21 GO:0003013 Not Cancer Driver No 81 0.113 73 6 0.082 0
SLC5A5 SLC5A5 Q92911 Sodium/iodide cotransporter chr19 GO:0003013 Not Cancer Driver No 96 0.149 59 7 0.119 5
SLC5A6 SLC5A6 Q9Y289 Sodium-dependent multivitamin transporter chr2 GO:0003013 Not Cancer Driver No 87 0.137 28 0 0.0 2
SLC6A13 SLC6A13 Q9NSD5 Sodium- and chloride-dependent GABA transporter 2 chr12 GO:0003013 Not Cancer Driver No 136 0.226 37 11 0.297 0
SLC6A17 SLC6A17 Q9H1V8 Sodium-dependent neutral amino acid transporter SLC6A17 chr1 GO:0003013 Not Cancer Driver No 119 0.164 67 10 0.149 2
SLC6A1_ENST00000643498 SLC6A1 P30531 Sodium- and chloride-dependent GABA transporter 1 chr3 GO:0003013 Not Cancer Driver No 119 0.199 24 9 0.375 4
SLC6A20 SLC6A20 Q9NP91 Sodium- and chloride-dependent transporter XTRP3 chr3 GO:0003013 Not Cancer Driver No 81 0.137 0 0 0.0 0
SLC6A4_ENST00000401766 SLC6A4 P31645 Sodium-dependent serotonin transporter chr17 GO:0003013 Not Cancer Driver No 101 0.16 73 12 0.164 0
SLC6A6_ENST00000622186 SLC6A6 P31641 Sodium- and chloride-dependent taurine transporter chr3 GO:0003013 Not Cancer Driver No 80 0.129 22 1 0.045 2
SLC6A9 SLC6A9 P48067 Sodium- and chloride-dependent glycine transporter 1 chr1 GO:0003013 Not Cancer Driver No 102 0.144 65 12 0.185 1
SLC7A1 SLC7A1 P30825 High affinity cationic amino acid transporter 1 chr13 GO:0003013 Not Cancer Driver No 89 0.141 17 3 0.176 0
SLC7A2_ENST00000494857 SLC7A2 P52569 Cationic amino acid transporter 2 chr8 GO:0003013 Not Cancer Driver No 113 0.172 36 6 0.167 0
SLC7A3 SLC7A3 Q8WY07 Cationic amino acid transporter 3 chrX GO:0003013 Not Cancer Driver No 124 0.2 16 5 0.312 0
SLC7A5 SLC7A5 Q01650 Large neutral amino acids transporter small subunit 1 chr16 GO:0003013 Not Cancer Driver No 62 0.122 35 1 0.029 0
SLC7A8 SLC7A8 Q9UHI5 Large neutral amino acids transporter small subunit 2 chr14 GO:0003013 Not Cancer Driver No 70 0.131 63 11 0.175 0
SLC8A1_ENST00000332839 SLC8A1 P32418 Sodium/calcium exchanger 1 chr2 GO:0003013 Not Cancer Driver No 305 0.313 158 48 0.304 0
SLC8A2 SLC8A2 Q9UPR5 Sodium/calcium exchanger 2 chr19 GO:0003013 Not Cancer Driver No 117 0.127 143 19 0.133 0
SLC9A3R1 SLC9A3R1 O14745 Na(+)/H(+) exchange regulatory cofactor NHE-RF1 chr17 GO:0003013 Not Cancer Driver No 19 0.053 318 16 0.05 4
SLCO1C1_ENST00000266509 SLCO1C1 Q9NYB5 Solute carrier organic anion transporter family member 1C1 chr12 GO:0003013 Not Cancer Driver No 197 0.277 19 7 0.368 0
SLCO2B1 SLCO2B1 O94956 Solute carrier organic anion transporter family member 2B1 chr11 GO:0003013 Not Cancer Driver No 114 0.161 99 18 0.182 0
SLCO3A1 SLCO3A1 Q9UIG8 Solute carrier organic anion transporter family member 3A1 chr15 GO:0003013 Not Cancer Driver No 140 0.197 64 9 0.141 0
SLIT2 SLIT2 O94813 Slit homolog 2 protein chr4 GO:0003013 Not Cancer Driver No 428 0.28 31 13 0.419 0
SMTNL1 SMTNL1 A8MU46 Smoothelin-like protein 1 chr11 GO:0003013 Not Cancer Driver No 80 0.162 372 54 0.145 0
SMTNL2 SMTNL2 Q2TAL5 Smoothelin-like protein 2 chr17 GO:0003013 Not Cancer Driver No 45 0.098 344 33 0.096 0
SNTA1 SNTA1 Q13424 Alpha-1-syntrophin chr20 GO:0003013 Not Cancer Driver No 43 0.085 238 14 0.059 2
SOD2_ENST00000367055 SOD2 P04179 Superoxide dismutase [Mn], mitochondrial chr6 GO:0003013 Not Cancer Driver No 32 0.144 25 5 0.2 0
SRC_ENST00000358208 SRC P12931 Proto-oncogene tyrosine-protein kinase Src chr20 GO:0003013 Census Yes 53 0.099 130 11 0.085 1
SVEP1 SVEP1 Q4LDE5 Sushi, von Willebrand factor type A, EGF and pentraxin domain-containing protein 1 chr9 GO:0003013 Not Cancer Driver No 626 0.175 229 33 0.144 0
TACR1 TACR1 P25103 Substance-P receptor chr2 GO:0003013 Not Cancer Driver No 69 0.17 28 2 0.071 0
TACR2 TACR2 P21452 Substance-K receptor chr10 GO:0003013 Not Cancer Driver No 61 0.153 11 4 0.364 0
TBXA2R_ENST00000375190 TBXA2R P21731 Thromboxane A2 receptor chr19 GO:0003013 Not Cancer Driver No 47 0.137 17 4 0.235 1
TBXAS1_ENST00000448866 TBXAS1 P24557 Thromboxane-A synthase chr7 GO:0003013 Not Cancer Driver No 116 0.218 44 8 0.182 4
TEK TEK Q02763 Angiopoietin-1 receptor chr9 GO:0003013 Not Cancer Driver No 219 0.195 126 22 0.175 10
TFRC_ENST00000392396 TFRC P02786 Transferrin receptor protein 1 chr3 GO:0003013 Census Yes 89 0.117 80 6 0.075 1
TGFB1 TGFB1 P01137 Transforming growth factor beta-1 proprotein chr19 GO:0003013 Not Cancer Driver No 41 0.105 41 4 0.098 10
TJP1_ENST00000346128 TJP1 Q07157 Tight junction protein ZO-1 chr15 GO:0003013 Not Cancer Driver No 198 0.113 1350 151 0.112 0
TJP2_ENST00000377245 TJP2 Q9UDY2 Tight junction protein ZO-2 chr9 GO:0003013 Not Cancer Driver No 149 0.125 919 113 0.123 1
TJP3_ENST00000541714 TJP3 O95049 Tight junction protein ZO-3 chr19 GO:0003013 Not Cancer Driver No 132 0.144 684 101 0.148 0
TNF TNF P01375 Tumor necrosis factor chr6 GO:0003013 Not Cancer Driver No 24 0.103 45 3 0.067 0
TRPM4 TRPM4 Q8TD43 Transient receptor potential cation channel subfamily M member 4 chr19 GO:0003013 Not Cancer Driver No 152 0.125 149 18 0.121 12
TRPV4 TRPV4 Q9HBA0 Transient receptor potential cation channel subfamily V member 4 chr12 GO:0003013 Not Cancer Driver No 142 0.163 231 34 0.147 44
UCN UCN P55089 Urocortin chr2 GO:0003013 Not Cancer Driver No 7 0.056 61 4 0.066 0
VEGFA_ENST00000523873 VEGFA P15692 Vascular endothelial growth factor A chr6 GO:0003013 Not Cancer Driver No 27 0.116 41 7 0.171 0
VSTM4 VSTM4 Q8IW00 V-set and transmembrane domain-containing protein 4 chr10 GO:0003013 Not Cancer Driver No 91 0.284 47 9 0.191 0
YES1_ENST00000314574 YES1 P07947 Tyrosine-protein kinase Yes chr18 GO:0003013 Not Cancer Driver No 65 0.12 62 10 0.161 0
ZDHHC21 ZDHHC21 Q8IVQ6 Palmitoyltransferase ZDHHC21 chr9 GO:0003013 Not Cancer Driver No 34 0.128 0 0 0.0 0