Total number of protein in "GO:0002718" GO term: 98
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ANGPT1 | ANGPT1 | Q15389 | Angiopoietin-1 | chr8 | GO:0002718 | Not Cancer Driver | No | 130 | 0.261 | 131 | 24 | 0.183 | 1 |
| APOA1_ENST00000375320 | APOA1 | P02647 | Apolipoprotein A-I | chr11 | GO:0002718 | Not Cancer Driver | No | 28 | 0.105 | 131 | 8 | 0.061 | 3 |
| APOA2 | APOA2 | P02652 | Apolipoprotein A-II | chr1 | GO:0002718 | Not Cancer Driver | No | 13 | 0.13 | 0 | 0 | 0.0 | 0 |
| ARG1_ENST00000368087 | ARG1 | P05089 | Arginase-1 | chr6 | GO:0002718 | Not Cancer Driver | No | 41 | 0.127 | 83 | 12 | 0.145 | 9 |
| ARID5A | ARID5A | Q03989 | AT-rich interactive domain-containing protein 5A | chr2 | GO:0002718 | Not Cancer Driver | No | 64 | 0.108 | 373 | 42 | 0.113 | 0 |
| ATG5_ENST00000343245 | ATG5 | Q9H1Y0 | Autophagy protein 5 | chr6 | GO:0002718 | Not Cancer Driver | No | 40 | 0.145 | 25 | 6 | 0.24 | 1 |
| B2M | B2M | P61769 | Beta-2-microglobulin | chr15 | GO:0002718 | Census, Compendium | Yes | 34 | 0.286 | 5 | 1 | 0.2 | 2 |
| BCL10 | BCL10 | O95999 | B-cell lymphoma/leukemia 10 | chr1 | GO:0002718 | Census, Compendium | Yes | 36 | 0.155 | 151 | 25 | 0.166 | 0 |
| BCL6_ENST00000232014 | BCL6 | P41182 | B-cell lymphoma 6 protein | chr3 | GO:0002718 | Census, Compendium | Yes | 134 | 0.19 | 328 | 67 | 0.204 | 0 |
| BST2 | BST2 | Q10589 | Bone marrow stromal antigen 2 | chr19 | GO:0002718 | Not Cancer Driver | No | 19 | 0.106 | 20 | 0 | 0.0 | 0 |
| BTK_ENST00000308731 | BTK | Q06187 | Tyrosine-protein kinase BTK | chrX | GO:0002718 | Census, Compendium | Yes | 147 | 0.223 | 114 | 27 | 0.237 | 110 |
| CAMK4_ENST00000512453 | CAMK4 | Q16566 | Calcium/calmodulin-dependent protein kinase type IV | chr5 | GO:0002718 | Not Cancer Driver | No | 101 | 0.214 | 127 | 30 | 0.236 | 0 |
| CCR2_ENST00000400888 | CCR2 | P41597 | C-C chemokine receptor type 2 | chr3 | GO:0002718 | Not Cancer Driver | No | 81 | 0.217 | 23 | 1 | 0.043 | 0 |
| CD160_ENST00000369288 | CD160 | O95971 | CD160 antigen | chr1 | GO:0002718 | Not Cancer Driver | No | 20 | 0.11 | 2 | 0 | 0.0 | 0 |
| CD226_ENST00000582621 | CD226 | Q15762 | CD226 antigen | chr18 | GO:0002718 | Not Cancer Driver | No | 79 | 0.235 | 47 | 11 | 0.234 | 0 |
| CD36_ENST00000309881 | CD36 | P16671 | Platelet glycoprotein 4 | chr7 | GO:0002718 | Not Cancer Driver | No | 75 | 0.159 | 12 | 3 | 0.25 | 3 |
| CD55_ENST00000367064 | CD55 | P08174 | Complement decay-accelerating factor | chr1 | GO:0002718 | Not Cancer Driver | No | 45 | 0.118 | 128 | 13 | 0.102 | 1 |
| CD74 | CD74 | P04233 | HLA class II histocompatibility antigen gamma chain | chr5 | GO:0002718 | Census | Yes | 31 | 0.105 | 185 | 20 | 0.108 | 0 |
| CD81 | CD81 | P60033 | CD81 antigen | chr11 | GO:0002718 | Not Cancer Driver | No | 28 | 0.119 | 0 | 0 | 0.0 | 0 |
| CD96 | CD96 | P40200 | T-cell surface protein tactile | chr3 | GO:0002718 | Not Cancer Driver | No | 132 | 0.226 | 165 | 34 | 0.206 | 1 |
| CLC | CLC | Q05315 | Galectin-10 | chr19 | GO:0002718 | Not Cancer Driver | No | 29 | 0.204 | 0 | 0 | 0.0 | 0 |
| CLEC7A | CLEC7A | Q9BXN2 | C-type lectin domain family 7 member A | chr12 | GO:0002718 | Not Cancer Driver | No | 43 | 0.174 | 46 | 2 | 0.043 | 0 |
| CLNK | CLNK | Q7Z7G1 | Cytokine-dependent hematopoietic cell linker | chr4 | GO:0002718 | Not Cancer Driver | No | 85 | 0.199 | 320 | 73 | 0.228 | 0 |
| CUEDC2 | CUEDC2 | Q9H467 | CUE domain-containing protein 2 | chr10 | GO:0002718 | Not Cancer Driver | No | 37 | 0.129 | 173 | 25 | 0.145 | 0 |
| DDX1 | DDX1 | Q92499 | ATP-dependent RNA helicase DDX1 | chr2 | GO:0002718 | Not Cancer Driver | No | 82 | 0.111 | 91 | 15 | 0.165 | 0 |
| DDX21 | DDX21 | Q9NR30 | Nucleolar RNA helicase 2 | chr10 | GO:0002718 | Not Cancer Driver | No | 72 | 0.092 | 342 | 30 | 0.088 | 0 |
| DDX58 | DDX58 | O95786 | Antiviral innate immune response receptor RIG-I | chr9 | GO:0002718 | Not Cancer Driver | No | 118 | 0.128 | 61 | 10 | 0.164 | 2 |
| DENND1B | DENND1B | Q6P3S1 | DENN domain-containing protein 1B | chr1 | GO:0002718 | Not Cancer Driver | No | 69 | 0.089 | 299 | 19 | 0.064 | 0 |
| DHX36 | DHX36 | Q9H2U1 | ATP-dependent DNA/RNA helicase DHX36 | chr3 | GO:0002718 | Not Cancer Driver | No | 159 | 0.158 | 222 | 39 | 0.176 | 0 |
| F2RL1 | F2RL1 | P55085 | Proteinase-activated receptor 2 | chr5 | GO:0002718 | Not Cancer Driver | No | 55 | 0.139 | 7 | 2 | 0.286 | 0 |
| FFAR2 | FFAR2 | O15552 | Free fatty acid receptor 2 | chr19 | GO:0002718 | Not Cancer Driver | No | 49 | 0.148 | 32 | 7 | 0.219 | 0 |
| FFAR3 | FFAR3 | O14843 | Free fatty acid receptor 3 | chr19 | GO:0002718 | Not Cancer Driver | No | 78 | 0.225 | 29 | 6 | 0.207 | 0 |
| FOXP3 | FOXP3 | Q9BZS1 | Forkhead box protein P3 | chrX | GO:0002718 | Not Cancer Driver | No | 38 | 0.088 | 186 | 16 | 0.086 | 10 |
| FZD5 | FZD5 | Q13467 | Frizzled-5 | chr2 | GO:0002718 | Not Cancer Driver | No | 45 | 0.077 | 58 | 4 | 0.069 | 0 |
| GATA3_ENST00000346208 | GATA3 | P23771 | Trans-acting T-cell-specific transcription factor GATA-3 | chr10 | GO:0002718 | Census, Compendium | Yes | 111 | 0.251 | 364 | 87 | 0.239 | 2 |
| GPRC5B_ENST00000569479 | GPRC5B | Q9NZH0 | G-protein coupled receptor family C group 5 member B | chr16 | GO:0002718 | Not Cancer Driver | No | 82 | 0.203 | 75 | 19 | 0.253 | 0 |
| HFE | HFE | Q30201 | Hereditary hemochromatosis protein | chr6 | GO:0002718 | Not Cancer Driver | No | 55 | 0.158 | 27 | 2 | 0.074 | 11 |
| HK1_ENST00000359426 | HK1 | P19367 | Hexokinase-1 | chr10 | GO:0002718 | Not Cancer Driver | No | 127 | 0.138 | 75 | 16 | 0.213 | 6 |
| HLA-A_ENST00000376809 | HLA-A | P04439 | HLA class I histocompatibility antigen, A alpha chain | chr6 | GO:0002718 | Census, Compendium | Yes | 128 | 0.351 | 125 | 60 | 0.48 | 0 |
| HLA-E | HLA-E | P13747 | HLA class I histocompatibility antigen, alpha chain E | chr6 | GO:0002718 | Not Cancer Driver | No | 63 | 0.176 | 138 | 39 | 0.283 | 0 |
| HLA-F_ENST00000376861 | HLA-F | P30511 | HLA class I histocompatibility antigen, alpha chain F | chr6 | GO:0002718 | Not Cancer Driver | No | 43 | 0.124 | 115 | 22 | 0.191 | 0 |
| HLA-G_ENST00000360323 | HLA-G | P17693 | HLA class I histocompatibility antigen, alpha chain G | chr6 | GO:0002718 | Not Cancer Driver | No | 94 | 0.278 | 85 | 22 | 0.259 | 0 |
| HMOX1 | HMOX1 | P09601 | Heme oxygenase 1 | chr22 | GO:0002718 | Not Cancer Driver | No | 46 | 0.16 | 81 | 13 | 0.16 | 0 |
| IFNA2 | IFNA2 | P01563 | Interferon alpha-2 | chr9 | GO:0002718 | Not Cancer Driver | No | 38 | 0.202 | 2 | 0 | 0.0 | 0 |
| IFNB1 | IFNB1 | P01574 | Interferon beta | chr9 | GO:0002718 | Not Cancer Driver | No | 46 | 0.246 | 0 | 0 | 0.0 | 0 |
| IL10 | IL10 | P22301 | Interleukin-10 | chr1 | GO:0002718 | Not Cancer Driver | No | 19 | 0.107 | 23 | 1 | 0.043 | 0 |
| IL18 | IL18 | Q14116 | Interleukin-18 | chr11 | GO:0002718 | Not Cancer Driver | No | 19 | 0.098 | 16 | 3 | 0.188 | 0 |
| IL18R1_ENST00000233957 | IL18R1 | Q13478 | Interleukin-18 receptor 1 | chr2 | GO:0002718 | Not Cancer Driver | No | 104 | 0.192 | 18 | 3 | 0.167 | 0 |
| IL1B | IL1B | P01584 | Interleukin-1 beta | chr2 | GO:0002718 | Not Cancer Driver | No | 39 | 0.145 | 16 | 3 | 0.188 | 0 |
| IL1R1 | IL1R1 | P14778 | Interleukin-1 receptor type 1 | chr2 | GO:0002718 | Not Cancer Driver | No | 77 | 0.135 | 59 | 8 | 0.136 | 0 |
| IL4 | IL4 | P05112 | Interleukin-4 | chr5 | GO:0002718 | Not Cancer Driver | No | 18 | 0.118 | 0 | 0 | 0.0 | 0 |
| IL6 | IL6 | P05231 | Interleukin-6 | chr7 | GO:0002718 | Not Cancer Driver | No | 35 | 0.165 | 58 | 7 | 0.121 | 0 |
| INAVA_ENST00000367342 | INAVA | Q3KP66 | Innate immunity activator protein | chr1 | GO:0002718 | Not Cancer Driver | No | 112 | 0.169 | 553 | 98 | 0.177 | 1 |
| IRAK3 | IRAK3 | Q9Y616 | Interleukin-1 receptor-associated kinase 3 | chr12 | GO:0002718 | Not Cancer Driver | No | 103 | 0.173 | 79 | 14 | 0.177 | 0 |
| JAK3 | JAK3 | P52333 | Tyrosine-protein kinase JAK3 | chr19 | GO:0002718 | Census, Compendium | Yes | 167 | 0.149 | 63 | 10 | 0.159 | 7 |
| KIT | KIT | P10721 | Mast/stem cell growth factor receptor Kit | chr4 | GO:0002718 | Census, Compendium | Yes | 226 | 0.232 | 83 | 33 | 0.398 | 21 |
| LACC1 | LACC1 | Q8IV20 | Purine nucleoside phosphorylase LACC1 | chr13 | GO:0002718 | Not Cancer Driver | No | 50 | 0.116 | 4 | 0 | 0.0 | 1 |
| LAPTM5 | LAPTM5 | Q13571 | Lysosomal-associated transmembrane protein 5 | chr1 | GO:0002718 | Not Cancer Driver | No | 46 | 0.176 | 16 | 6 | 0.375 | 0 |
| LILRB1_ENST00000396331 | LILRB1 | Q8NHL6 | Leukocyte immunoglobulin-like receptor subfamily B member 1 | chr19 | GO:0002718 | Not Cancer Driver | No | 203 | 0.312 | 291 | 97 | 0.333 | 0 |
| LILRB4 | LILRB4 | Q8NHJ6 | Leukocyte immunoglobulin-like receptor subfamily B member 4 | chr19 | GO:0002718 | Not Cancer Driver | No | 162 | 0.362 | 277 | 115 | 0.415 | 0 |
| MALT1 | MALT1 | Q9UDY8 | Mucosa-associated lymphoid tissue lymphoma translocation protein 1 | chr18 | GO:0002718 | Census, Compendium | Yes | 75 | 0.091 | 139 | 12 | 0.086 | 1 |
| MAP3K7 | MAP3K7 | O43318 | Mitogen-activated protein kinase kinase kinase 7 | chr6 | GO:0002718 | Not Cancer Driver | No | 104 | 0.172 | 333 | 66 | 0.198 | 6 |
| MAVS | MAVS | Q7Z434 | Mitochondrial antiviral-signaling protein | chr20 | GO:0002718 | Not Cancer Driver | No | 70 | 0.13 | 411 | 58 | 0.141 | 0 |
| MIF | MIF | P14174 | Macrophage migration inhibitory factor | chr22 | GO:0002718 | Not Cancer Driver | No | 4 | 0.035 | 0 | 0 | 0.0 | 0 |
| NLRP3_ENST00000391828 | NLRP3 | Q96P20 | NACHT, LRR and PYD domains-containing protein 3 | chr1 | GO:0002718 | Not Cancer Driver | No | 339 | 0.327 | 64 | 33 | 0.516 | 37 |
| NOD2 | NOD2 | Q9HC29 | Nucleotide-binding oligomerization domain-containing protein 2 | chr16 | GO:0002718 | Not Cancer Driver | No | 169 | 0.163 | 40 | 4 | 0.1 | 15 |
| NR4A3_ENST00000395097 | NR4A3 | Q92570 | Nuclear receptor subfamily 4 group A member 3 | chr9 | GO:0002718 | Census | Yes | 83 | 0.133 | 298 | 37 | 0.124 | 0 |
| PLCG2 | PLCG2 | P16885 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 | chr16 | GO:0002718 | Not Cancer Driver | No | 248 | 0.196 | 142 | 30 | 0.211 | 1 |
| PRKCZ | PRKCZ | Q05513 | Protein kinase C zeta type | chr1 | GO:0002718 | Not Cancer Driver | No | 70 | 0.118 | 116 | 11 | 0.095 | 0 |
| RAET1G | RAET1G | Q6H3X3 | UL-16 binding protein 5 | chr6 | GO:0002718 | Not Cancer Driver | No | 41 | 0.123 | 62 | 10 | 0.161 | 0 |
| RSAD2 | RSAD2 | Q8WXG1 | Radical S-adenosyl methionine domain-containing protein 2 | chr2 | GO:0002718 | Not Cancer Driver | No | 68 | 0.188 | 22 | 1 | 0.045 | 0 |
| SASH3 | SASH3 | O75995 | SAM and SH3 domain-containing protein 3 | chrX | GO:0002718 | Not Cancer Driver | No | 59 | 0.155 | 327 | 49 | 0.15 | 0 |
| SCIMP | SCIMP | Q6UWF3 | SLP adapter and CSK-interacting membrane protein | chr17 | GO:0002718 | Not Cancer Driver | No | 10 | 0.069 | 73 | 9 | 0.123 | 0 |
| SEMA7A | SEMA7A | O75326 | Semaphorin-7A | chr15 | GO:0002718 | Not Cancer Driver | No | 81 | 0.122 | 150 | 21 | 0.14 | 0 |
| SIRT1 | SIRT1 | Q96EB6 | NAD-dependent protein deacetylase sirtuin-1 | chr10 | GO:0002718 | Not Cancer Driver | No | 70 | 0.094 | 435 | 31 | 0.071 | 0 |
| SLAMF1_ENST00000302035 | SLAMF1 | Q13291 | Signaling lymphocytic activation molecule | chr1 | GO:0002718 | Not Cancer Driver | No | 82 | 0.245 | 64 | 10 | 0.156 | 0 |
| SLC7A5 | SLC7A5 | Q01650 | Large neutral amino acids transporter small subunit 1 | chr16 | GO:0002718 | Not Cancer Driver | No | 62 | 0.122 | 35 | 1 | 0.029 | 0 |
| SMAD7 | SMAD7 | O15105 | Mothers against decapentaplegic homolog 7 | chr18 | GO:0002718 | Not Cancer Driver | No | 40 | 0.094 | 139 | 0 | 0.0 | 0 |
| SPHK2 | SPHK2 | Q9NRA0 | Sphingosine kinase 2 | chr19 | GO:0002718 | Not Cancer Driver | No | 82 | 0.125 | 293 | 39 | 0.133 | 0 |
| SPON2_ENST00000431380 | SPON2 | Q9BUD6 | Spondin-2 | chr4 | GO:0002718 | Not Cancer Driver | No | 36 | 0.109 | 73 | 4 | 0.055 | 0 |
| TBX21 | TBX21 | Q9UL17 | T-box transcription factor TBX21 | chr17 | GO:0002718 | Not Cancer Driver | No | 70 | 0.131 | 348 | 50 | 0.144 | 0 |
| TGFB1 | TGFB1 | P01137 | Transforming growth factor beta-1 proprotein | chr19 | GO:0002718 | Not Cancer Driver | No | 41 | 0.105 | 41 | 4 | 0.098 | 10 |
| TGFB2_ENST00000366930 | TGFB2 | P61812 | Transforming growth factor beta-2 proprotein | chr1 | GO:0002718 | Not Cancer Driver | No | 63 | 0.152 | 47 | 8 | 0.17 | 3 |
| TGFB3 | TGFB3 | P10600 | Transforming growth factor beta-3 proprotein | chr14 | GO:0002718 | Not Cancer Driver | No | 45 | 0.109 | 96 | 14 | 0.146 | 1 |
| TICAM1 | TICAM1 | Q8IUC6 | TIR domain-containing adapter molecule 1 | chr19 | GO:0002718 | Not Cancer Driver | No | 92 | 0.129 | 443 | 66 | 0.149 | 1 |
| TLR3 | TLR3 | O15455 | Toll-like receptor 3 | chr4 | GO:0002718 | Not Cancer Driver | No | 123 | 0.136 | 0 | 0 | 0.0 | 1 |
| TLR4_ENST00000355622 | TLR4 | O00206 | Toll-like receptor 4 | chr9 | GO:0002718 | Not Cancer Driver | No | 292 | 0.348 | 0 | 0 | 0.0 | 0 |
| TNF | TNF | P01375 | Tumor necrosis factor | chr6 | GO:0002718 | Not Cancer Driver | No | 24 | 0.103 | 45 | 3 | 0.067 | 0 |
| TNFRSF14 | TNFRSF14 | Q92956 | Tumor necrosis factor receptor superfamily member 14 | chr1 | GO:0002718 | Census, Compendium | Yes | 33 | 0.117 | 54 | 8 | 0.148 | 0 |
| TNFRSF1B | TNFRSF1B | P20333 | Tumor necrosis factor receptor superfamily member 1B | chr1 | GO:0002718 | Not Cancer Driver | No | 48 | 0.104 | 229 | 28 | 0.122 | 0 |
| TNFSF4 | TNFSF4 | P23510 | Tumor necrosis factor ligand superfamily member 4 | chr1 | GO:0002718 | Not Cancer Driver | No | 28 | 0.153 | 1 | 0 | 0.0 | 0 |
| TRAF2 | TRAF2 | Q12933 | TNF receptor-associated factor 2 | chr9 | GO:0002718 | Not Cancer Driver | No | 63 | 0.126 | 4 | 1 | 0.25 | 0 |
| TRAF6_ENST00000348124 | TRAF6 | Q9Y4K3 | TNF receptor-associated factor 6 | chr11 | GO:0002718 | Not Cancer Driver | No | 67 | 0.128 | 62 | 7 | 0.113 | 0 |
| TRIL | TRIL | Q7L0X0 | TLR4 interactor with leucine rich repeats | chr7 | GO:0002718 | Not Cancer Driver | No | 60 | 0.074 | 199 | 13 | 0.065 | 0 |
| TRIM6_ENST00000278302 | TRIM6 | Q9C030 | Tripartite motif-containing protein 6 | chr11 | GO:0002718 | Not Cancer Driver | No | 86 | 0.176 | 47 | 15 | 0.319 | 0 |
| TRPM4 | TRPM4 | Q8TD43 | Transient receptor potential cation channel subfamily M member 4 | chr19 | GO:0002718 | Not Cancer Driver | No | 152 | 0.125 | 149 | 18 | 0.121 | 12 |
| WNT5A_ENST00000474267 | WNT5A | P41221 | Protein Wnt-5a | chr3 | GO:0002718 | Not Cancer Driver | No | 66 | 0.174 | 0 | 0 | 0.0 | 2 |
| XCL1 | XCL1 | P47992 | Lymphotactin | chr1 | GO:0002718 | Not Cancer Driver | No | 28 | 0.246 | 35 | 11 | 0.314 | 0 |