Total number of protein in "GO:0002253" GO term: 103
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ABL1_ENST00000318560 | ABL1 | P00519 | Tyrosine-protein kinase ABL1 | chr9 | GO:0002253 | Census, Compendium | Yes | 139 | 0.123 | 604 | 73 | 0.121 | 2 |
| AC136428.1 | IGHV3OR16-17 | S4R3C0 | Immunoglobulin heavy variable 3/OR16-17 (non-functional) (Fragment) | chr16 | GO:0002253 | Not Cancer Driver | No | 42 | 0.362 | 0 | 0 | 0.0 | 0 |
| APCS | APCS | P02743 | Serum amyloid P-component | chr1 | GO:0002253 | Not Cancer Driver | No | 73 | 0.327 | 0 | 0 | 0.0 | 0 |
| BAX_ENST00000345358 | BAX | Q07812 | Apoptosis regulator BAX | chr19 | GO:0002253 | Census | Yes | 30 | 0.156 | 39 | 2 | 0.051 | 0 |
| BLK | BLK | P51451 | Tyrosine-protein kinase Blk | chr8 | GO:0002253 | Not Cancer Driver | No | 94 | 0.186 | 75 | 21 | 0.28 | 0 |
| C1QA | C1QA | P02745 | Complement C1q subcomponent subunit A | chr1 | GO:0002253 | Not Cancer Driver | No | 41 | 0.167 | 124 | 16 | 0.129 | 0 |
| C1QB | C1QB | P02746 | Complement C1q subcomponent subunit B | chr1 | GO:0002253 | Not Cancer Driver | No | 46 | 0.182 | 133 | 31 | 0.233 | 1 |
| C1QBP | C1QBP | Q07021 | Complement component 1 Q subcomponent-binding protein, mitochondrial | chr17 | GO:0002253 | Not Cancer Driver | No | 14 | 0.05 | 103 | 6 | 0.058 | 2 |
| C1QC | C1QC | P02747 | Complement C1q subcomponent subunit C | chr1 | GO:0002253 | Not Cancer Driver | No | 46 | 0.188 | 134 | 26 | 0.194 | 1 |
| C1R | C1R | P00736 | Complement C1r subcomponent | chr12 | GO:0002253 | Not Cancer Driver | No | 88 | 0.125 | 51 | 6 | 0.118 | 6 |
| C1RL | C1RL | Q9NZP8 | Complement C1r subcomponent-like protein | chr12 | GO:0002253 | Not Cancer Driver | No | 60 | 0.123 | 146 | 22 | 0.151 | 0 |
| C1S | C1S | P09871 | Complement C1s subcomponent | chr12 | GO:0002253 | Not Cancer Driver | No | 128 | 0.186 | 97 | 21 | 0.216 | 1 |
| C2 | C2 | P06681 | Complement C2 | chr6 | GO:0002253 | Not Cancer Driver | No | 120 | 0.16 | 120 | 17 | 0.142 | 3 |
| C3 | C3 | P01024 | Complement C3 | chr19 | GO:0002253 | Not Cancer Driver | No | 337 | 0.203 | 287 | 50 | 0.174 | 12 |
| C3AR1 | C3AR1 | Q16581 | C3a anaphylatoxin chemotactic receptor | chr12 | GO:0002253 | Not Cancer Driver | No | 88 | 0.183 | 72 | 16 | 0.222 | 0 |
| C4A | C4A | P0C0L4 | Complement C4-A | chr6 | GO:0002253 | Not Cancer Driver | No | 43 | 0.025 | 309 | 6 | 0.019 | 0 |
| C4BPA | C4BPA | P04003 | C4b-binding protein alpha chain | chr1 | GO:0002253 | Not Cancer Driver | No | 109 | 0.183 | 40 | 10 | 0.25 | 0 |
| C4BPB | C4BPB | P20851 | C4b-binding protein beta chain | chr1 | GO:0002253 | Not Cancer Driver | No | 40 | 0.159 | 0 | 0 | 0.0 | 0 |
| C5 | C5 | P01031 | Complement C5 | chr9 | GO:0002253 | Not Cancer Driver | No | 192 | 0.115 | 84 | 9 | 0.107 | 0 |
| C5AR1 | C5AR1 | P21730 | C5a anaphylatoxin chemotactic receptor 1 | chr19 | GO:0002253 | Not Cancer Driver | No | 71 | 0.203 | 0 | 0 | 0.0 | 0 |
| C5AR2_ENST00000600626 | C5AR2 | Q9P296 | C5a anaphylatoxin chemotactic receptor 2 | chr19 | GO:0002253 | Not Cancer Driver | No | 60 | 0.178 | 11 | 3 | 0.273 | 0 |
| C6 | C6 | P13671 | Complement component C6 | chr5 | GO:0002253 | Not Cancer Driver | No | 346 | 0.37 | 121 | 47 | 0.388 | 0 |
| C7 | C7 | P10643 | Complement component C7 | chr5 | GO:0002253 | Not Cancer Driver | No | 291 | 0.345 | 89 | 37 | 0.416 | 5 |
| C8A | C8A | P07357 | Complement component C8 alpha chain | chr1 | GO:0002253 | Not Cancer Driver | No | 176 | 0.301 | 25 | 9 | 0.36 | 0 |
| C8B | C8B | P07358 | Complement component C8 beta chain | chr1 | GO:0002253 | Not Cancer Driver | No | 186 | 0.315 | 29 | 11 | 0.379 | 0 |
| C8G | C8G | P07360 | Complement component C8 gamma chain | chr9 | GO:0002253 | Not Cancer Driver | No | 10 | 0.05 | 26 | 2 | 0.077 | 0 |
| C9 | C9 | P02748 | Complement component C9 | chr5 | GO:0002253 | Not Cancer Driver | No | 156 | 0.279 | 40 | 8 | 0.2 | 2 |
| CD46_ENST00000358170 | CD46 | P15529 | Membrane cofactor protein | chr1 | GO:0002253 | Not Cancer Driver | No | 53 | 0.135 | 52 | 4 | 0.077 | 5 |
| CD55_ENST00000367064 | CD55 | P08174 | Complement decay-accelerating factor | chr1 | GO:0002253 | Not Cancer Driver | No | 45 | 0.118 | 128 | 13 | 0.102 | 1 |
| CFB | CFB | P00751 | Complement factor B | chr6 | GO:0002253 | Not Cancer Driver | No | 75 | 0.098 | 112 | 20 | 0.179 | 7 |
| CFD_ENST00000327726 | CFD | P00746 | Complement factor D | chr19 | GO:0002253 | Not Cancer Driver | No | 6 | 0.024 | 69 | 3 | 0.043 | 2 |
| CFH | CFH | P08603 | Complement factor H | chr1 | GO:0002253 | Not Cancer Driver | No | 355 | 0.288 | 89 | 28 | 0.315 | 42 |
| CFHR5 | CFHR5 | Q9BXR6 | Complement factor H-related protein 5 | chr1 | GO:0002253 | Not Cancer Driver | No | 162 | 0.285 | 40 | 9 | 0.225 | 0 |
| CFI_ENST00000394634 | CFI | P05156 | Complement factor I | chr4 | GO:0002253 | Not Cancer Driver | No | 97 | 0.166 | 4 | 0 | 0.0 | 13 |
| CFP | CFP | P27918 | Properdin | chrX | GO:0002253 | Not Cancer Driver | No | 60 | 0.128 | 48 | 7 | 0.146 | 6 |
| CLEC6A | CLEC6A | Q6EIG7 | C-type lectin domain family 6 member A | chr12 | GO:0002253 | Not Cancer Driver | No | 41 | 0.196 | 7 | 0 | 0.0 | 0 |
| CLEC7A | CLEC7A | Q9BXN2 | C-type lectin domain family 7 member A | chr12 | GO:0002253 | Not Cancer Driver | No | 43 | 0.174 | 46 | 2 | 0.043 | 0 |
| CLU_ENST00000523500 | CLU | P10909 | Clusterin | chr8 | GO:0002253 | Not Cancer Driver | No | 69 | 0.154 | 156 | 27 | 0.173 | 0 |
| CMKLR1 | CMKLR1 | Q99788 | Chemerin-like receptor 1 | chr12 | GO:0002253 | Not Cancer Driver | No | 107 | 0.287 | 24 | 13 | 0.542 | 0 |
| COLEC10 | COLEC10 | Q9Y6Z7 | Collectin-10 | chr8 | GO:0002253 | Not Cancer Driver | No | 58 | 0.209 | 95 | 23 | 0.242 | 1 |
| COLEC11_ENST00000349077 | COLEC11 | Q9BWP8 | Collectin-11 | chr2 | GO:0002253 | Not Cancer Driver | No | 72 | 0.266 | 158 | 40 | 0.253 | 2 |
| CR1_ENST00000367053 | CR1 | P17927 | Complement receptor type 1 | chr1 | GO:0002253 | Compendium | Yes | 383 | 0.188 | 151 | 42 | 0.278 | 0 |
| CR2_ENST00000367058 | CR2 | P20023 | Complement receptor type 2 | chr1 | GO:0002253 | Not Cancer Driver | No | 273 | 0.264 | 85 | 28 | 0.329 | 0 |
| CREBBP | CREBBP | Q92793 | CREB-binding protein | chr16 | GO:0002253 | Census, Compendium | Yes | 412 | 0.169 | 1796 | 247 | 0.138 | 33 |
| CRP | CRP | P02741 | C-reactive protein | chr1 | GO:0002253 | Not Cancer Driver | No | 59 | 0.263 | 0 | 0 | 0.0 | 0 |
| EP300 | EP300 | Q09472 | Histone acetyltransferase p300 | chr22 | GO:0002253 | Census, Compendium | Yes | 334 | 0.138 | 1790 | 196 | 0.109 | 1 |
| FCER1G | FCER1G | P30273 | High affinity immunoglobulin epsilon receptor subunit gamma | chr1 | GO:0002253 | Not Cancer Driver | No | 10 | 0.116 | 13 | 2 | 0.154 | 0 |
| FCGR2B | FCGR2B | P31994 | Low affinity immunoglobulin gamma Fc region receptor II-b | chr1 | GO:0002253 | Census | Yes | 51 | 0.165 | 99 | 30 | 0.303 | 0 |
| FCN1 | FCN1 | O00602 | Ficolin-1 | chr9 | GO:0002253 | Not Cancer Driver | No | 107 | 0.328 | 88 | 15 | 0.17 | 0 |
| FCN2 | FCN2 | Q15485 | Ficolin-2 | chr9 | GO:0002253 | Not Cancer Driver | No | 73 | 0.233 | 80 | 19 | 0.237 | 0 |
| FCN3 | FCN3 | O75636 | Ficolin-3 | chr1 | GO:0002253 | Not Cancer Driver | No | 46 | 0.154 | 65 | 19 | 0.292 | 0 |
| FFAR2 | FFAR2 | O15552 | Free fatty acid receptor 2 | chr19 | GO:0002253 | Not Cancer Driver | No | 49 | 0.148 | 32 | 7 | 0.219 | 0 |
| FGR_ENST00000374004 | FGR | P09769 | Tyrosine-protein kinase Fgr | chr1 | GO:0002253 | Not Cancer Driver | No | 85 | 0.161 | 52 | 8 | 0.154 | 0 |
| FPR1_ENST00000304748 | FPR1 | P21462 | fMet-Leu-Phe receptor | chr19 | GO:0002253 | Not Cancer Driver | No | 99 | 0.283 | 18 | 3 | 0.167 | 0 |
| FPR2 | FPR2 | P25090 | N-formyl peptide receptor 2 | chr19 | GO:0002253 | Not Cancer Driver | No | 96 | 0.274 | 26 | 5 | 0.192 | 0 |
| FPR3 | FPR3 | P25089 | N-formyl peptide receptor 3 | chr19 | GO:0002253 | Not Cancer Driver | No | 82 | 0.232 | 28 | 2 | 0.071 | 0 |
| FYN | FYN | P06241 | Tyrosine-protein kinase Fyn | chr6 | GO:0002253 | Not Cancer Driver | No | 92 | 0.171 | 70 | 13 | 0.186 | 0 |
| GPLD1 | GPLD1 | P80108 | Phosphatidylinositol-glycan-specific phospholipase D | chr6 | GO:0002253 | Not Cancer Driver | No | 153 | 0.182 | 36 | 9 | 0.25 | 0 |
| GPR32 | GPR32 | O75388 | Probable G-protein coupled receptor 32 | chr19 | GO:0002253 | Not Cancer Driver | No | 85 | 0.239 | 18 | 6 | 0.333 | 0 |
| HCK_ENST00000534862 | HCK | P08631 | Tyrosine-protein kinase HCK | chr20 | GO:0002253 | Not Cancer Driver | No | 112 | 0.213 | 124 | 25 | 0.202 | 0 |
| IGHD | IGHD | P01880 | Immunoglobulin heavy constant delta | chr14 | GO:0002253 | Not Cancer Driver | No | 61 | 0.159 | 245 | 40 | 0.163 | 0 |
| IGLL1 | IGLL1 | P15814 | Immunoglobulin lambda-like polypeptide 1 | chr22 | GO:0002253 | Not Cancer Driver | No | 25 | 0.117 | 144 | 18 | 0.125 | 1 |
| IGLL5 | IGLL5 | B9A064 | Immunoglobulin lambda-like polypeptide 5 | chr22 | GO:0002253 | Not Cancer Driver | No | 59 | 0.276 | 127 | 35 | 0.276 | 0 |
| IKBKB | IKBKB | O14920 | Inhibitor of nuclear factor kappa-B kinase subunit beta | chr8 | GO:0002253 | Census, Compendium | Yes | 106 | 0.14 | 211 | 31 | 0.147 | 1 |
| KLRC2 | KLRC2 | P26717 | NKG2-C type II integral membrane protein | chr12 | GO:0002253 | Not Cancer Driver | No | 55 | 0.238 | 45 | 17 | 0.378 | 0 |
| KLRC3_ENST00000396439 | KLRC3 | Q07444 | NKG2-E type II integral membrane protein | chr12 | GO:0002253 | Not Cancer Driver | No | 37 | 0.154 | 43 | 4 | 0.093 | 0 |
| KLRC4 | KLRC4 | O43908 | NKG2-F type II integral membrane protein | chr12 | GO:0002253 | Not Cancer Driver | No | 36 | 0.228 | 45 | 7 | 0.156 | 0 |
| KLRD1 | KLRD1 | Q13241 | Natural killer cells antigen CD94 | chr12 | GO:0002253 | Not Cancer Driver | No | 37 | 0.207 | 0 | 0 | 0.0 | 0 |
| KLRK1 | KLRK1 | P26718 | NKG2-D type II integral membrane protein | chr12 | GO:0002253 | Not Cancer Driver | No | 38 | 0.176 | 0 | 0 | 0.0 | 0 |
| KRT1 | KRT1 | P04264 | Keratin, type II cytoskeletal 1 | chr12 | GO:0002253 | Not Cancer Driver | No | 133 | 0.207 | 426 | 98 | 0.23 | 20 |
| LILRA2 | LILRA2 | Q8N149 | Leukocyte immunoglobulin-like receptor subfamily A member 2 | chr19 | GO:0002253 | Not Cancer Driver | No | 163 | 0.337 | 137 | 44 | 0.321 | 0 |
| LIMK1 | LIMK1 | P53667 | LIM domain kinase 1 | chr7 | GO:0002253 | Not Cancer Driver | No | 110 | 0.17 | 170 | 30 | 0.176 | 0 |
| LYN | LYN | P07948 | Tyrosine-protein kinase Lyn | chr8 | GO:0002253 | Census | Yes | 95 | 0.186 | 84 | 12 | 0.143 | 0 |
| MAP3K7 | MAP3K7 | O43318 | Mitogen-activated protein kinase kinase kinase 7 | chr6 | GO:0002253 | Not Cancer Driver | No | 104 | 0.172 | 333 | 66 | 0.198 | 6 |
| MASP1_ENST00000337774 | MASP1 | P48740 | Mannan-binding lectin serine protease 1 | chr3 | GO:0002253 | Not Cancer Driver | No | 142 | 0.203 | 72 | 14 | 0.194 | 0 |
| MASP2 | MASP2 | O00187 | Mannan-binding lectin serine protease 2 | chr1 | GO:0002253 | Not Cancer Driver | No | 99 | 0.144 | 58 | 11 | 0.19 | 2 |
| MBL2 | MBL2 | P11226 | Mannose-binding protein C | chr10 | GO:0002253 | Not Cancer Driver | No | 63 | 0.254 | 122 | 32 | 0.262 | 0 |
| MFAP4_ENST00000299610 | MFAP4 | P55083 | Microfibril-associated glycoprotein 4 | chr17 | GO:0002253 | Not Cancer Driver | No | 35 | 0.137 | 0 | 0 | 0.0 | 0 |
| MYO1G | MYO1G | B0I1T2 | Unconventional myosin-Ig | chr7 | GO:0002253 | Not Cancer Driver | No | 125 | 0.123 | 117 | 12 | 0.103 | 0 |
| NOD2 | NOD2 | Q9HC29 | Nucleotide-binding oligomerization domain-containing protein 2 | chr16 | GO:0002253 | Not Cancer Driver | No | 169 | 0.163 | 40 | 4 | 0.1 | 15 |
| NR4A3_ENST00000395097 | NR4A3 | Q92570 | Nuclear receptor subfamily 4 group A member 3 | chr9 | GO:0002253 | Census | Yes | 83 | 0.133 | 298 | 37 | 0.124 | 0 |
| PAK1_ENST00000356341 | PAK1 | Q13153 | Serine/threonine-protein kinase PAK 1 | chr11 | GO:0002253 | Not Cancer Driver | No | 57 | 0.105 | 299 | 30 | 0.1 | 2 |
| PAK2 | PAK2 | Q13177 | Serine/threonine-protein kinase PAK 2 | chr3 | GO:0002253 | Compendium | Yes | 89 | 0.17 | 242 | 49 | 0.202 | 0 |
| PAK3_ENST00000262836 | PAK3 | O75914 | Serine/threonine-protein kinase PAK 3 | chrX | GO:0002253 | Not Cancer Driver | No | 127 | 0.227 | 286 | 64 | 0.224 | 2 |
| PLA2G6 | PLA2G6 | O60733 | 85/88 kDa calcium-independent phospholipase A2 | chr22 | GO:0002253 | Not Cancer Driver | No | 108 | 0.134 | 148 | 23 | 0.155 | 11 |
| PLCG2 | PLCG2 | P16885 | 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 | chr16 | GO:0002253 | Not Cancer Driver | No | 248 | 0.196 | 142 | 30 | 0.211 | 1 |
| PLD2 | PLD2 | O14939 | Phospholipase D2 | chr17 | GO:0002253 | Not Cancer Driver | No | 107 | 0.115 | 97 | 8 | 0.082 | 0 |
| PLPP4 | PLPP4 | Q5VZY2 | Phospholipid phosphatase 4 | chr10 | GO:0002253 | Not Cancer Driver | No | 59 | 0.218 | 14 | 1 | 0.071 | 0 |
| PRKCD_ENST00000330452 | PRKCD | Q05655 | Protein kinase C delta type | chr3 | GO:0002253 | Compendium | Yes | 79 | 0.117 | 43 | 9 | 0.209 | 0 |
| PRKCE | PRKCE | Q02156 | Protein kinase C epsilon type | chr2 | GO:0002253 | Not Cancer Driver | No | 107 | 0.145 | 170 | 26 | 0.153 | 0 |
| PTK2_ENST00000522684 | PTK2 | Q05397 | Focal adhesion kinase 1 | chr8 | GO:0002253 | Not Cancer Driver | No | 134 | 0.127 | 425 | 55 | 0.129 | 0 |
| SERPING1 | SERPING1 | P05155 | Plasma protease C1 inhibitor | chr11 | GO:0002253 | Not Cancer Driver | No | 74 | 0.148 | 113 | 13 | 0.115 | 40 |
| SRC_ENST00000358208 | SRC | P12931 | Proto-oncogene tyrosine-protein kinase Src | chr20 | GO:0002253 | Census | Yes | 53 | 0.099 | 130 | 11 | 0.085 | 1 |
| SUSD4 | SUSD4 | Q5VX71 | Sushi domain-containing protein 4 | chr1 | GO:0002253 | Not Cancer Driver | No | 85 | 0.173 | 134 | 27 | 0.201 | 0 |
| SYK_ENST00000375746 | SYK | P43405 | Tyrosine-protein kinase SYK | chr9 | GO:0002253 | Census | Yes | 96 | 0.151 | 131 | 27 | 0.206 | 5 |
| TRAF6_ENST00000348124 | TRAF6 | Q9Y4K3 | TNF receptor-associated factor 6 | chr11 | GO:0002253 | Not Cancer Driver | No | 67 | 0.128 | 62 | 7 | 0.113 | 0 |
| TREX1_ENST00000625293 | TREX1 | Q9NSU2 | Three-prime repair exonuclease 1 | chr3 | GO:0002253 | Not Cancer Driver | No | 26 | 0.083 | 98 | 10 | 0.102 | 18 |
| TYROBP | TYROBP | O43914 | TYRO protein tyrosine kinase-binding protein | chr19 | GO:0002253 | Not Cancer Driver | No | 24 | 0.212 | 28 | 8 | 0.286 | 0 |
| VAV1 | VAV1 | P15498 | Proto-oncogene vav | chr19 | GO:0002253 | Census, Compendium | Yes | 165 | 0.195 | 113 | 19 | 0.168 | 0 |
| VAV2 | VAV2 | P52735 | Guanine nucleotide exchange factor VAV2 | chr9 | GO:0002253 | Not Cancer Driver | No | 127 | 0.145 | 135 | 17 | 0.126 | 0 |
| VAV3 | VAV3 | Q9UKW4 | Guanine nucleotide exchange factor VAV3 | chr1 | GO:0002253 | Not Cancer Driver | No | 153 | 0.181 | 102 | 18 | 0.176 | 0 |
| VSIG4 | VSIG4 | Q9Y279 | V-set and immunoglobulin domain-containing protein 4 | chrX | GO:0002253 | Not Cancer Driver | No | 73 | 0.183 | 70 | 13 | 0.186 | 0 |
| YES1_ENST00000314574 | YES1 | P07947 | Tyrosine-protein kinase Yes | chr18 | GO:0002253 | Not Cancer Driver | No | 65 | 0.12 | 62 | 10 | 0.161 | 0 |