Total number of protein in "GO:0002221" GO term: 74
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ALPK1_ENST00000177648 | ALPK1 | Q96QP1 | Alpha-protein kinase 1 | chr4 | GO:0002221 | Not Cancer Driver | No | 183 | 0.147 | 480 | 64 | 0.133 | 1 |
| BTK_ENST00000308731 | BTK | Q06187 | Tyrosine-protein kinase BTK | chrX | GO:0002221 | Census, Compendium | Yes | 147 | 0.223 | 114 | 27 | 0.237 | 110 |
| CD300LF_ENST00000326165 | CD300LF | Q8TDQ1 | CMRF35-like molecule 1 | chr17 | GO:0002221 | Not Cancer Driver | No | 36 | 0.124 | 88 | 11 | 0.125 | 0 |
| CD40 | CD40 | P25942 | Tumor necrosis factor receptor superfamily member 5 | chr20 | GO:0002221 | Not Cancer Driver | No | 39 | 0.141 | 56 | 6 | 0.107 | 2 |
| CLEC4E | CLEC4E | Q9ULY5 | C-type lectin domain family 4 member E | chr12 | GO:0002221 | Not Cancer Driver | No | 56 | 0.256 | 5 | 2 | 0.4 | 0 |
| CLEC7A | CLEC7A | Q9BXN2 | C-type lectin domain family 7 member A | chr12 | GO:0002221 | Not Cancer Driver | No | 43 | 0.174 | 46 | 2 | 0.043 | 0 |
| CLPB | CLPB | Q9H078 | Caseinolytic peptidase B protein homolog | chr11 | GO:0002221 | Not Cancer Driver | No | 69 | 0.098 | 224 | 25 | 0.112 | 11 |
| COLEC12 | COLEC12 | Q5KU26 | Collectin-12 | chr18 | GO:0002221 | Not Cancer Driver | No | 147 | 0.198 | 450 | 90 | 0.2 | 0 |
| CYLD | CYLD | Q9NQC7 | Ubiquitin carboxyl-terminal hydrolase CYLD | chr16 | GO:0002221 | Census, Compendium | Yes | 116 | 0.121 | 213 | 31 | 0.146 | 3 |
| DDX58 | DDX58 | O95786 | Antiviral innate immune response receptor RIG-I | chr9 | GO:0002221 | Not Cancer Driver | No | 118 | 0.128 | 61 | 10 | 0.164 | 2 |
| EPG5 | EPG5 | Q9HCE0 | Ectopic P granules protein 5 homolog | chr18 | GO:0002221 | Not Cancer Driver | No | 305 | 0.118 | 347 | 46 | 0.133 | 2 |
| FCN1 | FCN1 | O00602 | Ficolin-1 | chr9 | GO:0002221 | Not Cancer Driver | No | 107 | 0.328 | 88 | 15 | 0.17 | 0 |
| FFAR2 | FFAR2 | O15552 | Free fatty acid receptor 2 | chr19 | GO:0002221 | Not Cancer Driver | No | 49 | 0.148 | 32 | 7 | 0.219 | 0 |
| HAVCR2 | HAVCR2 | Q8TDQ0 | Hepatitis A virus cellular receptor 2 | chr5 | GO:0002221 | Not Cancer Driver | No | 69 | 0.229 | 17 | 2 | 0.118 | 3 |
| HSPD1 | HSPD1 | P10809 | 60 kDa heat shock protein, mitochondrial | chr2 | GO:0002221 | Not Cancer Driver | No | 61 | 0.106 | 82 | 6 | 0.073 | 2 |
| IFIH1 | IFIH1 | Q9BYX4 | Interferon-induced helicase C domain-containing protein 1 | chr2 | GO:0002221 | Not Cancer Driver | No | 109 | 0.106 | 287 | 36 | 0.125 | 9 |
| INAVA_ENST00000367342 | INAVA | Q3KP66 | Innate immunity activator protein | chr1 | GO:0002221 | Not Cancer Driver | No | 112 | 0.169 | 553 | 98 | 0.177 | 1 |
| IRAK1 | IRAK1 | P51617 | Interleukin-1 receptor-associated kinase 1 | chrX | GO:0002221 | Compendium | Yes | 71 | 0.1 | 337 | 39 | 0.116 | 0 |
| IRAK2 | IRAK2 | O43187 | Interleukin-1 receptor-associated kinase-like 2 | chr3 | GO:0002221 | Not Cancer Driver | No | 84 | 0.134 | 202 | 32 | 0.158 | 0 |
| IRAK3 | IRAK3 | Q9Y616 | Interleukin-1 receptor-associated kinase 3 | chr12 | GO:0002221 | Not Cancer Driver | No | 103 | 0.173 | 79 | 14 | 0.177 | 0 |
| IRAK4_ENST00000551736 | IRAK4 | Q9NWZ3 | Interleukin-1 receptor-associated kinase 4 | chr12 | GO:0002221 | Not Cancer Driver | No | 68 | 0.148 | 116 | 20 | 0.172 | 2 |
| IRF3_ENST00000597198 | IRF3 | Q14653 | Interferon regulatory factor 3 | chr19 | GO:0002221 | Not Cancer Driver | No | 36 | 0.084 | 204 | 21 | 0.103 | 1 |
| IRF7_ENST00000397574 | IRF7 | Q92985 | Interferon regulatory factor 7 | chr11 | GO:0002221 | Not Cancer Driver | No | 43 | 0.085 | 253 | 19 | 0.075 | 1 |
| IRGM | IRGM | A1A4Y4 | Immunity-related GTPase family M protein | chr5 | GO:0002221 | Not Cancer Driver | No | 9 | 0.05 | 45 | 1 | 0.022 | 0 |
| ITCH | ITCH | Q96J02 | E3 ubiquitin-protein ligase Itchy homolog | chr20 | GO:0002221 | Not Cancer Driver | No | 95 | 0.105 | 335 | 42 | 0.125 | 0 |
| LACC1 | LACC1 | Q8IV20 | Purine nucleoside phosphorylase LACC1 | chr13 | GO:0002221 | Not Cancer Driver | No | 50 | 0.116 | 4 | 0 | 0.0 | 1 |
| LGALS9 | LGALS9 | O00182 | Galectin-9 | chr17 | GO:0002221 | Not Cancer Driver | No | 54 | 0.152 | 65 | 16 | 0.246 | 0 |
| LSM14A_ENST00000433627 | LSM14A | Q8ND56 | Protein LSM14 homolog A | chr19 | GO:0002221 | Census | Yes | 67 | 0.145 | 408 | 63 | 0.154 | 0 |
| MAP2K6 | MAP2K6 | P52564 | Dual specificity mitogen-activated protein kinase kinase 6 | chr17 | GO:0002221 | Not Cancer Driver | No | 48 | 0.144 | 55 | 11 | 0.2 | 0 |
| MAP3K7 | MAP3K7 | O43318 | Mitogen-activated protein kinase kinase kinase 7 | chr6 | GO:0002221 | Not Cancer Driver | No | 104 | 0.172 | 333 | 66 | 0.198 | 6 |
| MBL2 | MBL2 | P11226 | Mannose-binding protein C | chr10 | GO:0002221 | Not Cancer Driver | No | 63 | 0.254 | 122 | 32 | 0.262 | 0 |
| MYD88_ENST00000396334 | MYD88 | Q99836 | Myeloid differentiation primary response protein MyD88 | chr3 | GO:0002221 | Census, Compendium | Yes | 37 | 0.125 | 47 | 1 | 0.021 | 2 |
| NFKBIA | NFKBIA | P25963 | NF-kappa-B inhibitor alpha | chr14 | GO:0002221 | Compendium | Yes | 37 | 0.117 | 102 | 9 | 0.088 | 1 |
| NOD1 | NOD1 | Q9Y239 | Nucleotide-binding oligomerization domain-containing protein 1 | chr7 | GO:0002221 | Not Cancer Driver | No | 130 | 0.136 | 38 | 7 | 0.184 | 0 |
| NOD2 | NOD2 | Q9HC29 | Nucleotide-binding oligomerization domain-containing protein 2 | chr16 | GO:0002221 | Not Cancer Driver | No | 169 | 0.163 | 40 | 4 | 0.1 | 15 |
| NR1H4 | NR1H4 | Q96RI1 | Bile acid receptor | chr12 | GO:0002221 | Not Cancer Driver | No | 111 | 0.228 | 78 | 18 | 0.231 | 0 |
| OAS1_ENST00000202917 | OAS1 | P00973 | 2'-5'-oligoadenylate synthase 1 | chr12 | GO:0002221 | Not Cancer Driver | No | 67 | 0.168 | 71 | 12 | 0.169 | 0 |
| OAS3 | OAS3 | Q9Y6K5 | 2'-5'-oligoadenylate synthase 3 | chr12 | GO:0002221 | Not Cancer Driver | No | 139 | 0.128 | 147 | 17 | 0.116 | 0 |
| OTULIN | OTULIN | Q96BN8 | Ubiquitin thioesterase otulin | chr5 | GO:0002221 | Not Cancer Driver | No | 47 | 0.134 | 97 | 5 | 0.052 | 2 |
| PHB2 | PHB2 | Q99623 | Prohibitin-2 | chr12 | GO:0002221 | Not Cancer Driver | No | 31 | 0.104 | 26 | 4 | 0.154 | 0 |
| PHB_ENST00000300408 | PHB1 | P35232 | Prohibitin 1 | chr17 | GO:0002221 | Not Cancer Driver | No | 37 | 0.136 | 4 | 1 | 0.25 | 0 |
| PIK3AP1 | PIK3AP1 | Q6ZUJ8 | Phosphoinositide 3-kinase adapter protein 1 | chr10 | GO:0002221 | Not Cancer Driver | No | 141 | 0.175 | 406 | 81 | 0.2 | 0 |
| PRKCE | PRKCE | Q02156 | Protein kinase C epsilon type | chr2 | GO:0002221 | Not Cancer Driver | No | 107 | 0.145 | 170 | 26 | 0.153 | 0 |
| RAB11FIP2_ENST00000355624 | RAB11FIP2 | Q7L804 | Rab11 family-interacting protein 2 | chr10 | GO:0002221 | Not Cancer Driver | No | 66 | 0.129 | 356 | 43 | 0.121 | 0 |
| REG3G | REG3G | Q6UW15 | Regenerating islet-derived protein 3-gamma | chr2 | GO:0002221 | Not Cancer Driver | No | 81 | 0.463 | 17 | 4 | 0.235 | 0 |
| RELA | RELA | Q04206 | Transcription factor p65 | chr11 | GO:0002221 | Compendium | Yes | 75 | 0.136 | 400 | 48 | 0.12 | 0 |
| RFTN1 | RFTN1 | Q14699 | Raftlin | chr3 | GO:0002221 | Not Cancer Driver | No | 87 | 0.151 | 319 | 44 | 0.138 | 0 |
| RIPK2 | RIPK2 | O43353 | Receptor-interacting serine/threonine-protein kinase 2 | chr8 | GO:0002221 | Not Cancer Driver | No | 63 | 0.117 | 143 | 20 | 0.14 | 0 |
| RNF135 | RNF135 | Q8IUD6 | E3 ubiquitin-protein ligase RNF135 | chr17 | GO:0002221 | Not Cancer Driver | No | 40 | 0.093 | 139 | 11 | 0.079 | 0 |
| SCARA3 | SCARA3 | Q6AZY7 | Scavenger receptor class A member 3 | chr8 | GO:0002221 | Not Cancer Driver | No | 80 | 0.132 | 230 | 29 | 0.126 | 0 |
| SCIMP | SCIMP | Q6UWF3 | SLP adapter and CSK-interacting membrane protein | chr17 | GO:0002221 | Not Cancer Driver | No | 10 | 0.069 | 73 | 9 | 0.123 | 0 |
| TICAM1 | TICAM1 | Q8IUC6 | TIR domain-containing adapter molecule 1 | chr19 | GO:0002221 | Not Cancer Driver | No | 92 | 0.129 | 443 | 66 | 0.149 | 1 |
| TICAM2 | TICAM2 | Q86XR7 | TIR domain-containing adapter molecule 2 | chr5 | GO:0002221 | Not Cancer Driver | No | 35 | 0.149 | 88 | 10 | 0.114 | 0 |
| TIFA_ENST00000500655 | TIFA | Q96CG3 | TRAF-interacting protein with FHA domain-containing protein A | chr4 | GO:0002221 | Not Cancer Driver | No | 17 | 0.092 | 32 | 5 | 0.156 | 0 |
| TIRAP_ENST00000392680 | TIRAP | P58753 | Toll/interleukin-1 receptor domain-containing adapter protein | chr11 | GO:0002221 | Not Cancer Driver | No | 28 | 0.127 | 80 | 6 | 0.075 | 0 |
| TLR10_ENST00000508334 | TLR10 | Q9BXR5 | Toll-like receptor 10 | chr4 | GO:0002221 | Not Cancer Driver | No | 122 | 0.15 | 9 | 1 | 0.111 | 0 |
| TLR1_ENST00000502213 | TLR1 | Q15399 | Toll-like receptor 1 | chr4 | GO:0002221 | Not Cancer Driver | No | 107 | 0.136 | 1 | 0 | 0.0 | 0 |
| TLR2 | TLR2 | O60603 | Toll-like receptor 2 | chr4 | GO:0002221 | Not Cancer Driver | No | 108 | 0.138 | 0 | 0 | 0.0 | 0 |
| TLR3 | TLR3 | O15455 | Toll-like receptor 3 | chr4 | GO:0002221 | Not Cancer Driver | No | 123 | 0.136 | 0 | 0 | 0.0 | 1 |
| TLR4_ENST00000355622 | TLR4 | O00206 | Toll-like receptor 4 | chr9 | GO:0002221 | Not Cancer Driver | No | 292 | 0.348 | 0 | 0 | 0.0 | 0 |
| TLR5_ENST00000366881 | TLR5 | O60602 | Toll-like receptor 5 | chr1 | GO:0002221 | Not Cancer Driver | No | 148 | 0.172 | 16 | 3 | 0.188 | 0 |
| TLR6 | TLR6 | Q9Y2C9 | Toll-like receptor 6 | chr4 | GO:0002221 | Not Cancer Driver | No | 99 | 0.124 | 1 | 0 | 0.0 | 0 |
| TLR7 | TLR7 | Q9NYK1 | Toll-like receptor 7 | chrX | GO:0002221 | Not Cancer Driver | No | 182 | 0.173 | 14 | 1 | 0.071 | 1 |
| TLR8_ENST00000218032 | TLR8 | Q9NR97 | Toll-like receptor 8 | chrX | GO:0002221 | Not Cancer Driver | No | 180 | 0.173 | 30 | 7 | 0.233 | 0 |
| TLR9 | TLR9 | Q9NR96 | Toll-like receptor 9 | chr3 | GO:0002221 | Not Cancer Driver | No | 141 | 0.137 | 35 | 3 | 0.086 | 0 |
| TNF | TNF | P01375 | Tumor necrosis factor | chr6 | GO:0002221 | Not Cancer Driver | No | 24 | 0.103 | 45 | 3 | 0.067 | 0 |
| TNFAIP3 | TNFAIP3 | P21580 | Tumor necrosis factor alpha-induced protein 3 | chr6 | GO:0002221 | Census, Compendium | Yes | 98 | 0.124 | 231 | 33 | 0.143 | 1 |
| TNIP1_ENST00000522226 | TNIP1 | Q15025 | TNFAIP3-interacting protein 1 | chr5 | GO:0002221 | Not Cancer Driver | No | 85 | 0.134 | 625 | 83 | 0.133 | 0 |
| TNIP2 | TNIP2 | Q8NFZ5 | TNFAIP3-interacting protein 2 | chr4 | GO:0002221 | Not Cancer Driver | No | 43 | 0.1 | 316 | 36 | 0.114 | 0 |
| TNIP3_ENST00000057513 | TNIP3 | Q96KP6 | TNFAIP3-interacting protein 3 | chr4 | GO:0002221 | Not Cancer Driver | No | 97 | 0.298 | 249 | 72 | 0.289 | 0 |
| TRAF3_ENST00000392745 | TRAF3 | Q13114 | TNF receptor-associated factor 3 | chr14 | GO:0002221 | Compendium | Yes | 61 | 0.107 | 101 | 9 | 0.089 | 1 |
| TRAF6_ENST00000348124 | TRAF6 | Q9Y4K3 | TNF receptor-associated factor 6 | chr11 | GO:0002221 | Not Cancer Driver | No | 67 | 0.128 | 62 | 7 | 0.113 | 0 |
| TRIM25 | TRIM25 | Q14258 | E3 ubiquitin/ISG15 ligase TRIM25 | chr17 | GO:0002221 | Not Cancer Driver | No | 59 | 0.094 | 225 | 20 | 0.089 | 0 |
| UNC93B1 | UNC93B1 | Q9H1C4 | Protein unc-93 homolog B1 | chr11 | GO:0002221 | Not Cancer Driver | No | 57 | 0.095 | 127 | 5 | 0.039 | 0 |