Total number of protein in "GO:0001889" GO term: 99
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ACADM_ENST00000370841 | ACADM | P11310 | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | chr1 | GO:0001889 | Not Cancer Driver | No | 61 | 0.145 | 41 | 5 | 0.122 | 19 |
| ACAT1 | ACAT1 | P24752 | Acetyl-CoA acetyltransferase, mitochondrial | chr11 | GO:0001889 | Not Cancer Driver | No | 45 | 0.105 | 32 | 1 | 0.031 | 10 |
| ACO2 | ACO2 | Q99798 | Aconitate hydratase, mitochondrial | chr22 | GO:0001889 | Not Cancer Driver | No | 94 | 0.121 | 172 | 19 | 0.11 | 5 |
| ADA | ADA | P00813 | Adenosine deaminase | chr20 | GO:0001889 | Not Cancer Driver | No | 50 | 0.138 | 44 | 9 | 0.205 | 27 |
| ALDH1A2 | ALDH1A2 | O94788 | Retinal dehydrogenase 2 | chr15 | GO:0001889 | Not Cancer Driver | No | 100 | 0.193 | 56 | 13 | 0.232 | 0 |
| ARF6 | ARF6 | P62330 | ADP-ribosylation factor 6 | chr14 | GO:0001889 | Not Cancer Driver | No | 18 | 0.103 | 5 | 0 | 0.0 | 0 |
| ARG1_ENST00000368087 | ARG1 | P05089 | Arginase-1 | chr6 | GO:0001889 | Not Cancer Driver | No | 41 | 0.127 | 83 | 12 | 0.145 | 9 |
| ARID5B | ARID5B | Q14865 | AT-rich interactive domain-containing protein 5B | chr10 | GO:0001889 | Not Cancer Driver | No | 162 | 0.136 | 769 | 95 | 0.124 | 0 |
| ASS1_ENST00000352480 | ASS1 | P00966 | Argininosuccinate synthase | chr9 | GO:0001889 | Not Cancer Driver | No | 65 | 0.158 | 63 | 8 | 0.127 | 86 |
| ATF2 | ATF2 | P15336 | Cyclic AMP-dependent transcription factor ATF-2 | chr2 | GO:0001889 | Not Cancer Driver | No | 65 | 0.129 | 451 | 58 | 0.129 | 0 |
| ATP7A | ATP7A | Q04656 | Copper-transporting ATPase 1 | chrX | GO:0001889 | Not Cancer Driver | No | 228 | 0.152 | 171 | 46 | 0.269 | 52 |
| AURKA_ENST00000395915 | AURKA | O14965 | Aurora kinase A | chr20 | GO:0001889 | Not Cancer Driver | No | 36 | 0.089 | 178 | 21 | 0.118 | 0 |
| BAAT_ENST00000395051 | BAAT | Q14032 | Bile acid-CoA:amino acid N-acyltransferase | chr9 | GO:0001889 | Not Cancer Driver | No | 88 | 0.211 | 10 | 4 | 0.4 | 1 |
| CADM1_ENST00000452722 | CADM1 | Q9BY67 | Cell adhesion molecule 1 | chr11 | GO:0001889 | Not Cancer Driver | No | 106 | 0.24 | 103 | 28 | 0.272 | 0 |
| CCND1 | CCND1 | P24385 | G1/S-specific cyclin-D1 | chr11 | GO:0001889 | Census, Compendium | Yes | 55 | 0.186 | 31 | 25 | 0.806 | 0 |
| CDK5RAP3_ENST00000338399 | CDK5RAP3 | Q96JB5 | CDK5 regulatory subunit-associated protein 3 | chr17 | GO:0001889 | Not Cancer Driver | No | 50 | 0.099 | 99 | 20 | 0.202 | 0 |
| CDKN2B | CDKN2B | P42772 | Cyclin-dependent kinase 4 inhibitor B | chr9 | GO:0001889 | Not Cancer Driver | No | 15 | 0.109 | 67 | 3 | 0.045 | 0 |
| CEBPA | CEBPA | P49715 | CCAAT/enhancer-binding protein alpha | chr19 | GO:0001889 | Census, Compendium | Yes | 12 | 0.034 | 342 | 12 | 0.035 | 1 |
| CEBPB | CEBPB | P17676 | CCAAT/enhancer-binding protein beta | chr20 | GO:0001889 | Not Cancer Driver | No | 3 | 0.009 | 276 | 2 | 0.007 | 0 |
| CEBPG_ENST00000585933 | CEBPG | P53567 | CCAAT/enhancer-binding protein gamma | chr19 | GO:0001889 | Not Cancer Driver | No | 13 | 0.087 | 141 | 12 | 0.085 | 0 |
| CITED2_ENST00000367651 | CITED2 | Q99967 | Cbp/p300-interacting transactivator 2 | chr6 | GO:0001889 | Not Cancer Driver | No | 23 | 0.085 | 230 | 18 | 0.078 | 0 |
| CIT_ENST00000261833 | CIT | O14578 | Citron Rho-interacting kinase | chr12 | GO:0001889 | Not Cancer Driver | No | 284 | 0.14 | 1017 | 160 | 0.157 | 3 |
| CLDN1 | CLDN1 | O95832 | Claudin-1 | chr3 | GO:0001889 | Not Cancer Driver | No | 31 | 0.147 | 16 | 3 | 0.188 | 0 |
| COBL_ENST00000265136 | COBL | O75128 | Protein cordon-bleu | chr7 | GO:0001889 | Not Cancer Driver | No | 233 | 0.185 | 1149 | 216 | 0.188 | 0 |
| CPB2_ENST00000645658 | CPB2 | Q96IY4 | Carboxypeptidase B2 | chr13 | GO:0001889 | Not Cancer Driver | No | 59 | 0.139 | 2 | 0 | 0.0 | 0 |
| CPT1A_ENST00000539743 | CPT1A | P50416 | Carnitine O-palmitoyltransferase 1, liver isoform | chr11 | GO:0001889 | Not Cancer Driver | No | 144 | 0.186 | 62 | 10 | 0.161 | 15 |
| CSNK2A2 | CSNK2A2 | P19784 | Casein kinase II subunit alpha' | chr16 | GO:0001889 | Not Cancer Driver | No | 43 | 0.123 | 13 | 1 | 0.077 | 0 |
| ELK1_ENST00000376983 | ELK1 | P19419 | ETS domain-containing protein Elk-1 | chrX | GO:0001889 | Not Cancer Driver | No | 51 | 0.119 | 327 | 34 | 0.104 | 0 |
| EZH2_ENST00000460911 | EZH2 | Q15910 | Histone-lysine N-methyltransferase EZH2 | chr7 | GO:0001889 | Census, Compendium | Yes | 120 | 0.161 | 284 | 44 | 0.155 | 11 |
| FPGS | FPGS | Q05932 | Folylpolyglutamate synthase, mitochondrial | chr9 | GO:0001889 | Not Cancer Driver | No | 68 | 0.116 | 141 | 18 | 0.128 | 0 |
| GATA6 | GATA6 | Q92908 | Transcription factor GATA-6 | chr18 | GO:0001889 | Not Cancer Driver | No | 57 | 0.096 | 476 | 51 | 0.107 | 10 |
| GFER | GFER | P55789 | FAD-linked sulfhydryl oxidase ALR | chr16 | GO:0001889 | Not Cancer Driver | No | 10 | 0.049 | 97 | 4 | 0.041 | 1 |
| GLI1 | GLI1 | P08151 | Zinc finger protein GLI1 | chr12 | GO:0001889 | Census, Compendium | Yes | 206 | 0.186 | 1015 | 184 | 0.181 | 0 |
| GLI3 | GLI3 | P10071 | Transcriptional activator GLI3 | chr7 | GO:0001889 | Not Cancer Driver | No | 385 | 0.244 | 1352 | 327 | 0.242 | 7 |
| HAMP_ENST00000222304 | HAMP | P81172 | Hepcidin | chr19 | GO:0001889 | Not Cancer Driver | No | 7 | 0.083 | 4 | 0 | 0.0 | 4 |
| HES1 | HES1 | Q14469 | Transcription factor HES-1 | chr3 | GO:0001889 | Not Cancer Driver | No | 37 | 0.132 | 226 | 32 | 0.142 | 0 |
| HGF_ENST00000644543 | HGF | P14210 | Hepatocyte growth factor | chr7 | GO:0001889 | Compendium | Yes | 233 | 0.32 | 43 | 16 | 0.372 | 0 |
| HLX | HLX | Q14774 | H2.0-like homeobox protein | chr1 | GO:0001889 | Not Cancer Driver | No | 107 | 0.219 | 412 | 98 | 0.238 | 0 |
| HMGCS2 | HMGCS2 | P54868 | Hydroxymethylglutaryl-CoA synthase, mitochondrial | chr1 | GO:0001889 | Not Cancer Driver | No | 92 | 0.181 | 29 | 4 | 0.138 | 19 |
| HMOX1 | HMOX1 | P09601 | Heme oxygenase 1 | chr22 | GO:0001889 | Not Cancer Driver | No | 46 | 0.16 | 81 | 13 | 0.16 | 0 |
| HNF1A_ENST00000257555 | HNF1A | P20823 | Hepatocyte nuclear factor 1-alpha | chr12 | GO:0001889 | Census, Compendium | Yes | 96 | 0.152 | 569 | 80 | 0.141 | 42 |
| HNRNPD | HNRNPD | Q14103 | Heterogeneous nuclear ribonucleoprotein D0 | chr4 | GO:0001889 | Not Cancer Driver | No | 39 | 0.11 | 206 | 19 | 0.092 | 0 |
| IGF2R | IGF2R | P11717 | Cation-independent mannose-6-phosphate receptor | chr6 | GO:0001889 | Not Cancer Driver | No | 318 | 0.128 | 255 | 20 | 0.078 | 0 |
| IHH | IHH | Q14623 | Indian hedgehog protein | chr2 | GO:0001889 | Not Cancer Driver | No | 58 | 0.141 | 111 | 15 | 0.135 | 6 |
| IL10 | IL10 | P22301 | Interleukin-10 | chr1 | GO:0001889 | Not Cancer Driver | No | 19 | 0.107 | 23 | 1 | 0.043 | 0 |
| IL6 | IL6 | P05231 | Interleukin-6 | chr7 | GO:0001889 | Not Cancer Driver | No | 35 | 0.165 | 58 | 7 | 0.121 | 0 |
| JARID2 | JARID2 | Q92833 | Protein Jumonji | chr6 | GO:0001889 | Not Cancer Driver | No | 190 | 0.152 | 724 | 113 | 0.156 | 0 |
| JUN | JUN | P05412 | Transcription factor Jun | chr1 | GO:0001889 | Census | Yes | 35 | 0.106 | 281 | 25 | 0.089 | 0 |
| LSR_ENST00000361790 | LSR | Q86X29 | Lipolysis-stimulated lipoprotein receptor | chr19 | GO:0001889 | Not Cancer Driver | No | 89 | 0.137 | 330 | 42 | 0.127 | 0 |
| MAN2A1 | MAN2A1 | Q16706 | Alpha-mannosidase 2 | chr5 | GO:0001889 | Not Cancer Driver | No | 165 | 0.144 | 83 | 9 | 0.108 | 0 |
| MED1 | MED1 | Q15648 | Mediator of RNA polymerase II transcription subunit 1 | chr17 | GO:0001889 | Not Cancer Driver | No | 162 | 0.102 | 1104 | 117 | 0.106 | 0 |
| MET_ENST00000397752 | MET | P08581 | Hepatocyte growth factor receptor | chr7 | GO:0001889 | Census, Compendium | Yes | 226 | 0.163 | 62 | 15 | 0.242 | 19 |
| MPST_ENST00000341116 | MPST | P25325 | 3-mercaptopyruvate sulfurtransferase | chr22 | GO:0001889 | Not Cancer Driver | No | 20 | 0.067 | 72 | 8 | 0.111 | 0 |
| MYC_ENST00000377970 | MYC | P01106 | Myc proto-oncogene protein | chr8 | GO:0001889 | Census, Compendium | Yes | 80 | 0.182 | 299 | 46 | 0.154 | 0 |
| NF1 | NF1 | P21359 | Neurofibromin | chr17 | GO:0001889 | Census, Compendium | Yes | 375 | 0.132 | 406 | 47 | 0.116 | 85 |
| NKX2-8 | NKX2-8 | O15522 | Homeobox protein Nkx-2.8 | chr14 | GO:0001889 | Not Cancer Driver | No | 18 | 0.075 | 162 | 16 | 0.099 | 0 |
| NODAL | NODAL | Q96S42 | Nodal homolog | chr10 | GO:0001889 | Not Cancer Driver | No | 40 | 0.115 | 34 | 8 | 0.235 | 4 |
| NOTCH1 | NOTCH1 | P46531 | Neurogenic locus notch homolog protein 1 | chr9 | GO:0001889 | Census, Compendium | Yes | 363 | 0.142 | 686 | 87 | 0.127 | 3 |
| ONECUT1 | ONECUT1 | Q9UBC0 | Hepatocyte nuclear factor 6 | chr15 | GO:0001889 | Not Cancer Driver | No | 78 | 0.168 | 405 | 65 | 0.16 | 0 |
| ONECUT2 | ONECUT2 | O95948 | One cut domain family member 2 | chr18 | GO:0001889 | Not Cancer Driver | No | 76 | 0.151 | 408 | 54 | 0.132 | 0 |
| OTC | OTC | P00480 | Ornithine transcarbamylase, mitochondrial | chrX | GO:0001889 | Not Cancer Driver | No | 89 | 0.251 | 24 | 4 | 0.167 | 111 |
| PCNA | PCNA | P12004 | Proliferating cell nuclear antigen | chr20 | GO:0001889 | Not Cancer Driver | No | 30 | 0.115 | 22 | 3 | 0.136 | 1 |
| PCSK9 | PCSK9 | Q8NBP7 | Proprotein convertase subtilisin/kexin type 9 | chr1 | GO:0001889 | Not Cancer Driver | No | 86 | 0.124 | 148 | 27 | 0.182 | 9 |
| PDX1 | PDX1 | P52945 | Pancreas/duodenum homeobox protein 1 | chr13 | GO:0001889 | Not Cancer Driver | No | 32 | 0.113 | 238 | 23 | 0.097 | 0 |
| PHF2 | PHF2 | O75151 | Lysine-specific demethylase PHF2 | chr9 | GO:0001889 | Not Cancer Driver | No | 131 | 0.12 | 725 | 80 | 0.11 | 0 |
| PIK3CA | PIK3CA | P42336 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | chr3 | GO:0001889 | Census, Compendium | Yes | 1669 | 1.563 | 38 | 11 | 0.289 | 30 |
| PKD1 | PKD1 | P98161 | Polycystin-1 | chr16 | GO:0001889 | Not Cancer Driver | No | 393 | 0.091 | 690 | 66 | 0.096 | 92 |
| PKD2 | PKD2 | Q13563 | Polycystin-2 | chr4 | GO:0001889 | Not Cancer Driver | No | 113 | 0.117 | 375 | 35 | 0.093 | 10 |
| PNPT1 | PNPT1 | Q8TCS8 | Polyribonucleotide nucleotidyltransferase 1, mitochondrial | chr2 | GO:0001889 | Not Cancer Driver | No | 86 | 0.11 | 115 | 10 | 0.087 | 2 |
| PRKCSH_ENST00000589838 | PRKCSH | P14314 | Glucosidase 2 subunit beta | chr19 | GO:0001889 | Not Cancer Driver | No | 68 | 0.129 | 320 | 41 | 0.128 | 0 |
| PRMT5 | PRMT5 | O14744 | Protein arginine N-methyltransferase 5 | chr14 | GO:0001889 | Not Cancer Driver | No | 83 | 0.13 | 72 | 6 | 0.083 | 0 |
| PROX1 | PROX1 | Q92786 | Prospero homeobox protein 1 | chr1 | GO:0001889 | Not Cancer Driver | No | 182 | 0.247 | 537 | 141 | 0.263 | 0 |
| PTCD2 | PTCD2 | Q8WV60 | Pentatricopeptide repeat-containing protein 2, mitochondrial | chr5 | GO:0001889 | Not Cancer Driver | No | 46 | 0.119 | 9 | 0 | 0.0 | 0 |
| PTCH1 | PTCH1 | Q13635 | Protein patched homolog 1 | chr9 | GO:0001889 | Census, Compendium | Yes | 243 | 0.168 | 382 | 67 | 0.175 | 18 |
| PTPN3 | PTPN3 | P26045 | Tyrosine-protein phosphatase non-receptor type 3 | chr9 | GO:0001889 | Not Cancer Driver | No | 139 | 0.152 | 214 | 28 | 0.131 | 0 |
| RARA | RARA | P10276 | Retinoic acid receptor alpha | chr17 | GO:0001889 | Census, Compendium | Yes | 70 | 0.152 | 167 | 14 | 0.084 | 0 |
| RB1CC1 | RB1CC1 | Q8TDY2 | RB1-inducible coiled-coil protein 1 | chr8 | GO:0001889 | Not Cancer Driver | No | 202 | 0.127 | 578 | 75 | 0.13 | 0 |
| RELA | RELA | Q04206 | Transcription factor p65 | chr11 | GO:0001889 | Compendium | Yes | 75 | 0.136 | 400 | 48 | 0.12 | 0 |
| RGN | RGN | Q15493 | Regucalcin | chrX | GO:0001889 | Not Cancer Driver | No | 38 | 0.127 | 14 | 3 | 0.214 | 0 |
| RHBDD3 | RHBDD3 | Q9Y3P4 | Rhomboid domain-containing protein 3 | chr22 | GO:0001889 | Not Cancer Driver | No | 24 | 0.062 | 147 | 16 | 0.109 | 0 |
| RPGRIP1L_ENST00000379925 | RPGRIP1L | Q68CZ1 | Protein fantom | chr16 | GO:0001889 | Not Cancer Driver | No | 177 | 0.135 | 586 | 94 | 0.16 | 8 |
| RPS15_ENST00000592588 | RPS15 | P62841 | 40S ribosomal protein S15 | chr19 | GO:0001889 | Not Cancer Driver | No | 13 | 0.09 | 59 | 7 | 0.119 | 0 |
| SEC63 | SEC63 | Q9UGP8 | Translocation protein SEC63 homolog | chr6 | GO:0001889 | Not Cancer Driver | No | 98 | 0.129 | 266 | 37 | 0.139 | 0 |
| SERPINA10 | SERPINA10 | Q9UK55 | Protein Z-dependent protease inhibitor | chr14 | GO:0001889 | Not Cancer Driver | No | 108 | 0.243 | 74 | 18 | 0.243 | 0 |
| SMAD3 | SMAD3 | P84022 | Mothers against decapentaplegic homolog 3 | chr15 | GO:0001889 | Census, Compendium | Yes | 97 | 0.228 | 111 | 19 | 0.171 | 5 |
| SOD2_ENST00000367055 | SOD2 | P04179 | Superoxide dismutase [Mn], mitochondrial | chr6 | GO:0001889 | Not Cancer Driver | No | 32 | 0.144 | 25 | 5 | 0.2 | 0 |
| SP3 | SP3 | Q02447 | Transcription factor Sp3 | chr2 | GO:0001889 | Not Cancer Driver | No | 66 | 0.085 | 587 | 37 | 0.063 | 0 |
| SRD5A1 | SRD5A1 | P18405 | 3-oxo-5-alpha-steroid 4-dehydrogenase 1 | chr5 | GO:0001889 | Not Cancer Driver | No | 35 | 0.135 | 0 | 0 | 0.0 | 0 |
| SRSF5_ENST00000557154 | SRSF5 | Q13243 | Serine/arginine-rich splicing factor 5 | chr14 | GO:0001889 | Not Cancer Driver | No | 50 | 0.184 | 189 | 40 | 0.212 | 0 |
| TGFBR3_ENST00000525962 | TGFBR3 | Q03167 | Transforming growth factor beta receptor type 3 | chr1 | GO:0001889 | Not Cancer Driver | No | 129 | 0.152 | 268 | 41 | 0.153 | 0 |
| TNF | TNF | P01375 | Tumor necrosis factor | chr6 | GO:0001889 | Not Cancer Driver | No | 24 | 0.103 | 45 | 3 | 0.067 | 0 |
| TYMS | TYMS | P04818 | Thymidylate synthase | chr18 | GO:0001889 | Not Cancer Driver | No | 22 | 0.07 | 41 | 0 | 0.0 | 0 |
| UCP2 | UCP2 | P55851 | Mitochondrial uncoupling protein 2 | chr11 | GO:0001889 | Not Cancer Driver | No | 31 | 0.1 | 11 | 3 | 0.273 | 0 |
| UGT1A1 | UGT1A1 | P22309 | UDP-glucuronosyltransferase 1A1 | chr2 | GO:0001889 | Not Cancer Driver | No | 100 | 0.188 | 11 | 2 | 0.182 | 55 |
| UPB1 | UPB1 | Q9UBR1 | Beta-ureidopropionase | chr22 | GO:0001889 | Not Cancer Driver | No | 66 | 0.172 | 22 | 7 | 0.318 | 8 |
| UPF2_ENST00000357604 | UPF2 | Q9HAU5 | Regulator of nonsense transcripts 2 | chr10 | GO:0001889 | Not Cancer Driver | No | 150 | 0.118 | 632 | 84 | 0.133 | 0 |
| WNT4 | WNT4 | P56705 | Protein Wnt-4 | chr1 | GO:0001889 | Not Cancer Driver | No | 30 | 0.085 | 39 | 4 | 0.103 | 4 |
| XBP1 | XBP1 | P17861 | X-box-binding protein 1 | chr22 | GO:0001889 | Not Cancer Driver | No | 19 | 0.073 | 169 | 9 | 0.053 | 0 |
| ZMPSTE24 | ZMPSTE24 | O75844 | CAAX prenyl protease 1 homolog | chr1 | GO:0001889 | Not Cancer Driver | No | 67 | 0.141 | 23 | 0 | 0.0 | 3 |