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Total number of protein in "GO:0001568" GO term:  114

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ACVR2B ACVR2B Q13705 Activin receptor type-2B chr3 GO:0001568 Not Cancer Driver No 83 0.162 70 14 0.2 2
ACVRL1 ACVRL1 P37023 Serine/threonine-protein kinase receptor R3 chr12 GO:0001568 Not Cancer Driver No 93 0.185 60 11 0.183 82
ADAMTS6 ADAMTS6 Q9UKP5 A disintegrin and metalloproteinase with thrombospondin motifs 6 chr5 GO:0001568 Not Cancer Driver No 166 0.149 75 11 0.147 0
AHR AHR P35869 Aryl hydrocarbon receptor chr7 GO:0001568 Not Cancer Driver No 129 0.152 351 75 0.214 0
AKT1_ENST00000349310 AKT1 P31749 RAC-alpha serine/threonine-protein kinase chr14 GO:0001568 Census, Compendium Yes 108 0.225 158 24 0.152 4
ALDH1A2 ALDH1A2 O94788 Retinal dehydrogenase 2 chr15 GO:0001568 Not Cancer Driver No 100 0.193 56 13 0.232 0
ANGPT1 ANGPT1 Q15389 Angiopoietin-1 chr8 GO:0001568 Not Cancer Driver No 130 0.261 131 24 0.183 1
ANGPT2 ANGPT2 O15123 Angiopoietin-2 chr8 GO:0001568 Not Cancer Driver No 63 0.127 96 10 0.104 1
ANTXR1 ANTXR1 Q9H6X2 Anthrax toxin receptor 1 chr2 GO:0001568 Not Cancer Driver No 105 0.186 183 44 0.24 0
AP2B1_ENST00000621914 AP2B1 P63010 AP-2 complex subunit beta chr17 GO:0001568 Not Cancer Driver No 85 0.091 95 12 0.126 0
APELA APELA P0DMC3 Apelin receptor early endogenous ligand chr4 GO:0001568 Not Cancer Driver No 1 0.019 0 0 0.0 0
APLN APLN Q9ULZ1 Apelin chrX GO:0001568 Not Cancer Driver No 8 0.104 51 6 0.118 0
APLNR APLNR P35414 Apelin receptor chr11 GO:0001568 Not Cancer Driver No 96 0.253 29 8 0.276 0
ATP7A ATP7A Q04656 Copper-transporting ATPase 1 chrX GO:0001568 Not Cancer Driver No 228 0.152 171 46 0.269 52
BMP4 BMP4 P12644 Bone morphogenetic protein 4 chr14 GO:0001568 Not Cancer Driver No 86 0.211 142 26 0.183 5
BMPER BMPER Q8N8U9 BMP-binding endothelial regulator protein chr7 GO:0001568 Not Cancer Driver No 196 0.286 0 0 0.0 1
BMPR2 BMPR2 Q13873 Bone morphogenetic protein receptor type-2 chr2 GO:0001568 Compendium Yes 141 0.136 601 70 0.116 19
CCN1 CCN1 O00622 CCN family member 1 chr1 GO:0001568 Not Cancer Driver No 33 0.087 12 0 0.0 0
CDX2 CDX2 Q99626 Homeobox protein CDX-2 chr13 GO:0001568 Census, Compendium Yes 39 0.125 271 35 0.129 0
CDX4 CDX4 O14627 Homeobox protein CDX-4 chrX GO:0001568 Not Cancer Driver No 86 0.303 188 54 0.287 0
CEACAM1 CEACAM1 P13688 Carcinoembryonic antigen-related cell adhesion molecule 1 chr19 GO:0001568 Not Cancer Driver No 64 0.122 241 25 0.104 0
CFC1 CFC1 P0CG37 Cryptic protein chr2 GO:0001568 Not Cancer Driver No 25 0.112 68 23 0.338 1
CFC1B CFC1B P0CG36 Cryptic family protein 1B chr2 GO:0001568 Not Cancer Driver No 2 0.009 55 1 0.018 0
CNTRL_ENST00000238341 CNTRL Q7Z7A1 Centriolin chr9 GO:0001568 Census Yes 234 0.101 1556 159 0.102 0
COL1A1 COL1A1 P02452 Collagen alpha-1(I) chain chr17 GO:0001568 Census, Compendium Yes 247 0.169 1212 214 0.177 148
COL1A2 COL1A2 P08123 Collagen alpha-2(I) chain chr7 GO:0001568 Not Cancer Driver No 372 0.272 1159 329 0.284 83
COL5A1 COL5A1 P20908 Collagen alpha-1(V) chain chr9 GO:0001568 Not Cancer Driver No 451 0.245 1456 385 0.264 7
CRKL CRKL P46109 Crk-like protein chr22 GO:0001568 Not Cancer Driver No 38 0.125 160 25 0.156 0
DCTN5 DCTN5 Q9BTE1 Dynactin subunit 5 chr16 GO:0001568 Not Cancer Driver No 23 0.126 0 0 0.0 0
DLX3 DLX3 O60479 Homeobox protein DLX-3 chr17 GO:0001568 Not Cancer Driver No 46 0.16 201 28 0.139 0
DYNC2H1_ENST00000375735 DYNC2H1 Q8NCM8 Cytoplasmic dynein 2 heavy chain 1 chr11 GO:0001568 Not Cancer Driver No 510 0.118 282 15 0.053 34
EDNRA EDNRA P25101 Endothelin-1 receptor chr4 GO:0001568 Not Cancer Driver No 62 0.145 21 6 0.286 2
EFEMP2 EFEMP2 O95967 EGF-containing fibulin-like extracellular matrix protein 2 chr11 GO:0001568 Not Cancer Driver No 67 0.151 41 4 0.098 8
EGFL7_ENST00000308874 EGFL7 Q9UHF1 Epidermal growth factor-like protein 7 chr9 GO:0001568 Not Cancer Driver No 24 0.088 36 2 0.056 0
EGR2 EGR2 P11161 E3 SUMO-protein ligase EGR2 chr10 GO:0001568 Compendium Yes 90 0.189 352 59 0.168 11
FBXW8 FBXW8 Q8N3Y1 F-box/WD repeat-containing protein 8 chr12 GO:0001568 Not Cancer Driver No 68 0.114 120 4 0.033 0
FLVCR1 FLVCR1 Q9Y5Y0 Feline leukemia virus subgroup C receptor-related protein 1 chr1 GO:0001568 Not Cancer Driver No 58 0.105 117 14 0.12 4
FOSL1 FOSL1 P15407 Fos-related antigen 1 chr11 GO:0001568 Not Cancer Driver No 24 0.089 271 24 0.089 0
FOXF1 FOXF1 Q12946 Forkhead box protein F1 chr16 GO:0001568 Not Cancer Driver No 56 0.148 194 20 0.103 20
FOXO1 FOXO1 Q12778 Forkhead box protein O1 chr13 GO:0001568 Census, Compendium Yes 81 0.124 584 75 0.128 0
FOXS1 FOXS1 O43638 Forkhead box protein S1 chr20 GO:0001568 Not Cancer Driver No 67 0.203 226 41 0.181 0
FZD5 FZD5 Q13467 Frizzled-5 chr2 GO:0001568 Not Cancer Driver No 45 0.077 58 4 0.069 0
GJA4 GJA4 P35212 Gap junction alpha-4 protein chr1 GO:0001568 Not Cancer Driver No 48 0.144 74 14 0.189 0
GLI3 GLI3 P10071 Transcriptional activator GLI3 chr7 GO:0001568 Not Cancer Driver No 385 0.244 1352 327 0.242 7
GPC3_ENST00000370818 GPC3 P51654 Glypican-3 chrX GO:0001568 Census Yes 89 0.153 86 11 0.128 1
HECTD1 HECTD1 Q9ULT8 E3 ubiquitin-protein ligase HECTD1 chr14 GO:0001568 Not Cancer Driver No 274 0.105 991 108 0.109 0
HES1 HES1 Q14469 Transcription factor HES-1 chr3 GO:0001568 Not Cancer Driver No 37 0.132 226 32 0.142 0
HEY1_ENST00000354724 HEY1 Q9Y5J3 Hairy/enhancer-of-split related with YRPW motif protein 1 chr8 GO:0001568 Census Yes 33 0.109 172 15 0.087 0
HEY2 HEY2 Q9UBP5 Hairy/enhancer-of-split related with YRPW motif protein 2 chr6 GO:0001568 Not Cancer Driver No 64 0.19 179 26 0.145 0
HOXA1_ENST00000643460 HOXA1 P49639 Homeobox protein Hox-A1 chr7 GO:0001568 Not Cancer Driver No 90 0.269 262 68 0.26 0
HS6ST1 HS6ST1 O60243 Heparan-sulfate 6-O-sulfotransferase 1 chr2 GO:0001568 Not Cancer Driver No 60 0.146 66 14 0.212 6
ITGB8 ITGB8 P26012 Integrin beta-8 chr7 GO:0001568 Not Cancer Driver No 126 0.164 26 3 0.115 0
JUNB JUNB P17275 Transcription factor JunB chr19 GO:0001568 Not Cancer Driver No 20 0.058 305 16 0.052 0
LEP LEP P41159 Leptin chr7 GO:0001568 Not Cancer Driver No 29 0.174 0 0 0.0 2
LOXL1 LOXL1 Q08397 Lysyl oxidase homolog 1 chr15 GO:0001568 Not Cancer Driver No 49 0.085 337 14 0.042 0
LRP2 LRP2 P98164 Low-density lipoprotein receptor-related protein 2 chr2 GO:0001568 Not Cancer Driver No 998 0.214 209 40 0.191 1
LUZP1_ENST00000418342 LUZP1 Q86V48 Leucine zipper protein 1 chr1 GO:0001568 Not Cancer Driver No 102 0.095 972 91 0.094 0
MAP2K1 MAP2K1 Q02750 Dual specificity mitogen-activated protein kinase kinase 1 chr15 GO:0001568 Census, Compendium Yes 94 0.239 96 24 0.25 6
MAP3K3_ENST00000361733 MAP3K3 Q99759 Mitogen-activated protein kinase kinase kinase 3 chr17 GO:0001568 Not Cancer Driver No 74 0.118 355 44 0.124 0
MAPK1_ENST00000398822 MAPK1 P28482 Mitogen-activated protein kinase 1 chr22 GO:0001568 Census, Compendium Yes 62 0.172 2 0 0.0 7
MDM2_ENST00000539479 MDM2 Q00987 E3 ubiquitin-protein ligase Mdm2 chr12 GO:0001568 Census, Compendium Yes 56 0.114 297 37 0.125 0
MEF2C_ENST00000504921 MEF2C Q06413 Myocyte-specific enhancer factor 2C chr5 GO:0001568 Not Cancer Driver No 92 0.195 408 81 0.199 0
MEGF8 MEGF8 Q7Z7M0 Multiple epidermal growth factor-like domains protein 8 chr19 GO:0001568 Not Cancer Driver No 363 0.128 476 59 0.124 3
MIB1 MIB1 Q86YT6 E3 ubiquitin-protein ligase MIB1 chr18 GO:0001568 Not Cancer Driver No 122 0.121 282 34 0.121 1
MMP21 MMP21 Q8N119 Matrix metalloproteinase-21 chr10 GO:0001568 Not Cancer Driver No 75 0.132 147 11 0.075 8
NDST1 NDST1 P52848 Bifunctional heparan sulfate N-deacetylase/N-sulfotransferase 1 chr5 GO:0001568 Not Cancer Driver No 117 0.133 22 1 0.045 4
NGFR NGFR P08138 Tumor necrosis factor receptor superfamily member 16 chr17 GO:0001568 Not Cancer Driver No 57 0.133 172 25 0.145 0
NKX3-1 NKX3-1 Q99801 Homeobox protein Nkx-3.1 chr8 GO:0001568 Not Cancer Driver No 35 0.15 171 16 0.094 0
NOTCH2 NOTCH2 Q04721 Neurogenic locus notch homolog protein 2 chr1 GO:0001568 Census, Compendium Yes 282 0.114 630 77 0.122 1
NR2F2 NR2F2 P24468 COUP transcription factor 2 chr15 GO:0001568 Not Cancer Driver No 66 0.159 101 1 0.01 5
NSDHL NSDHL Q15738 Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating chrX GO:0001568 Not Cancer Driver No 60 0.161 39 6 0.154 3
OSR1 OSR1 Q8TAX0 Protein odd-skipped-related 1 chr2 GO:0001568 Not Cancer Driver No 57 0.214 67 17 0.254 0
OVOL2 OVOL2 Q9BRP0 Transcription factor Ovo-like 2 chr20 GO:0001568 Not Cancer Driver No 29 0.105 139 8 0.058 0
PAX6_ENST00000241001 PAX6 P26367 Paired box protein Pax-6 chr11 GO:0001568 Not Cancer Driver No 72 0.171 337 56 0.166 38
PDE2A PDE2A O00408 cGMP-dependent 3',5'-cyclic phosphodiesterase chr11 GO:0001568 Not Cancer Driver No 137 0.146 99 7 0.071 0
PKD1 PKD1 P98161 Polycystin-1 chr16 GO:0001568 Not Cancer Driver No 393 0.091 690 66 0.096 92
PKD2 PKD2 Q13563 Polycystin-2 chr4 GO:0001568 Not Cancer Driver No 113 0.117 375 35 0.093 10
PLCD3 PLCD3 Q8N3E9 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3 chr17 GO:0001568 Not Cancer Driver No 61 0.077 229 22 0.096 0
PLG PLG P00747 Plasminogen chr6 GO:0001568 Not Cancer Driver No 242 0.299 230 64 0.278 9
PLXND1 PLXND1 Q9Y4D7 Plexin-D1 chr3 GO:0001568 Not Cancer Driver No 246 0.128 321 35 0.109 0
PRDM1 PRDM1 O75626 PR domain zinc finger protein 1 chr6 GO:0001568 Census, Compendium Yes 145 0.176 337 66 0.196 0
PRICKLE1_ENST00000640055 PRICKLE1 Q96MT3 Prickle-like protein 1 chr12 GO:0001568 Not Cancer Driver No 146 0.176 485 91 0.188 3
PROP1 PROP1 O75360 Homeobox protein prophet of Pit-1 chr5 GO:0001568 Not Cancer Driver No 35 0.155 194 32 0.165 7
PSEN1 PSEN1 P49768 Presenilin-1 chr14 GO:0001568 Not Cancer Driver No 61 0.131 134 21 0.157 96
PTK7_ENST00000230419 PTK7 Q13308 Inactive tyrosine-protein kinase 7 chr6 GO:0001568 Not Cancer Driver No 153 0.143 359 58 0.162 0
RAPGEF2 RAPGEF2 Q9Y4G8 Rap guanine nucleotide exchange factor 2 chr4 GO:0001568 Not Cancer Driver No 216 0.144 803 116 0.144 0
RBM15 RBM15 Q96T37 RNA-binding protein 15 chr1 GO:0001568 Census, Compendium Yes 118 0.121 686 91 0.133 0
RBPJ_ENST00000361572 RBPJ Q06330 Recombining binding protein suppressor of hairless chr4 GO:0001568 Not Cancer Driver No 49 0.098 151 19 0.126 2
ROBO1 ROBO1 Q9Y6N7 Roundabout homolog 1 chr3 GO:0001568 Not Cancer Driver No 353 0.214 1122 234 0.209 0
ROBO2_ENST00000461745 ROBO2 Q9HCK4 Roundabout homolog 2 chr3 GO:0001568 Census Yes 407 0.295 874 259 0.296 2
SHH SHH Q15465 Sonic hedgehog protein chr7 GO:0001568 Not Cancer Driver No 56 0.121 139 14 0.101 81
SLC2A10 SLC2A10 O95528 Solute carrier family 2, facilitated glucose transporter member 10 chr20 GO:0001568 Not Cancer Driver No 98 0.181 72 15 0.208 8
SMAD6 SMAD6 O43541 Mothers against decapentaplegic homolog 6 chr15 GO:0001568 Not Cancer Driver No 38 0.077 248 7 0.028 7
SNX17 SNX17 Q15036 Sorting nexin-17 chr2 GO:0001568 Not Cancer Driver No 55 0.117 118 10 0.085 0
SOCS3 SOCS3 O14543 Suppressor of cytokine signaling 3 chr17 GO:0001568 Not Cancer Driver No 27 0.12 111 14 0.126 0
SPHK1_ENST00000545180 SPHK1 Q9NYA1 Sphingosine kinase 1 chr17 GO:0001568 Not Cancer Driver No 47 0.122 25 2 0.08 0
SPHK2 SPHK2 Q9NRA0 Sphingosine kinase 2 chr19 GO:0001568 Not Cancer Driver No 82 0.125 293 39 0.133 0
SPINT1 SPINT1 O43278 Kunitz-type protease inhibitor 1 chr15 GO:0001568 Not Cancer Driver No 63 0.119 75 12 0.16 0
STRA6_ENST00000323940 STRA6 Q9BX79 Receptor for retinol uptake STRA6 chr15 GO:0001568 Not Cancer Driver No 77 0.115 84 14 0.167 6
SUFU SUFU Q9UMX1 Suppressor of fused homolog chr10 GO:0001568 Census Yes 55 0.114 199 19 0.095 2
TAB1 TAB1 Q15750 TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 chr22 GO:0001568 Not Cancer Driver No 81 0.161 232 34 0.147 0
TBX1_ENST00000329705 TBX1 O43435 T-box transcription factor TBX1 chr22 GO:0001568 Not Cancer Driver No 35 0.088 197 12 0.061 4
TBX3 TBX3 O15119 T-box transcription factor TBX3 chr12 GO:0001568 Census, Compendium Yes 123 0.166 352 57 0.162 2
TCF7L2_ENST00000355995 TCF7L2 Q9NQB0 Transcription factor 7-like 2 chr10 GO:0001568 Census, Compendium Yes 122 0.197 516 93 0.18 0
TDGF1 TDGF1 P13385 Teratocarcinoma-derived growth factor 1 chr3 GO:0001568 Not Cancer Driver No 39 0.207 25 2 0.08 0
TEK TEK Q02763 Angiopoietin-1 receptor chr9 GO:0001568 Not Cancer Driver No 219 0.195 126 22 0.175 10
TGFBR2_ENST00000295754 TGFBR2 P37173 TGF-beta receptor type-2 chr3 GO:0001568 Census, Compendium Yes 106 0.187 60 16 0.267 25
TMED2 TMED2 Q15363 Transmembrane emp24 domain-containing protein 2 chr12 GO:0001568 Not Cancer Driver No 24 0.119 25 4 0.16 0
TREX1_ENST00000625293 TREX1 Q9NSU2 Three-prime repair exonuclease 1 chr3 GO:0001568 Not Cancer Driver No 26 0.083 98 10 0.102 18
VASH1 VASH1 Q7L8A9 Tubulinyl-Tyr carboxypeptidase 1 chr14 GO:0001568 Not Cancer Driver No 39 0.107 215 18 0.084 0
VASH2 VASH2 Q86V25 Tubulinyl-Tyr carboxypeptidase 2 chr1 GO:0001568 Not Cancer Driver No 32 0.09 106 9 0.085 0
VEGFB VEGFB P49765 Vascular endothelial growth factor B chr11 GO:0001568 Not Cancer Driver No 25 0.121 125 22 0.176 0
WNT2 WNT2 P09544 Protein Wnt-2 chr7 GO:0001568 Not Cancer Driver No 85 0.236 11 3 0.273 0
ZBTB14_ENST00000615385 ZBTB14 O43829 Zinc finger and BTB domain-containing protein 14 chr18 GO:0001568 Not Cancer Driver No 72 0.16 207 28 0.135 0