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Total number of protein in "GO:0000165" GO term:  113

Identifier UniProt Gene UniProt Accession UniProt Name Chromosome GO term Database Cancer Driver Number of missense mutations Missense mutation per residues Number of disordered residues Number of mutations in disordered regions Disordered missense mutations per residues Number of OMIM mutation
ARAF_ENST00000377045 ARAF P10398 Serine/threonine-protein kinase A-Raf chrX GO:0000165 Census, Compendium Yes 84 0.139 181 32 0.177 0
ATF2 ATF2 P15336 Cyclic AMP-dependent transcription factor ATF-2 chr2 GO:0000165 Not Cancer Driver No 65 0.129 451 58 0.129 0
BRAF BRAF P15056 Serine/threonine-protein kinase B-raf chr7 GO:0000165 Census, Compendium Yes 791 1.033 310 43 0.139 39
BRAP BRAP Q7Z569 BRCA1-associated protein chr12 GO:0000165 Not Cancer Driver No 70 0.118 192 24 0.125 0
CAMKK2 CAMKK2 Q96RR4 Calcium/calmodulin-dependent protein kinase kinase 2 chr12 GO:0000165 Not Cancer Driver No 65 0.111 281 35 0.125 0
CCL2 CCL2 P13500 C-C motif chemokine 2 chr17 GO:0000165 Not Cancer Driver No 20 0.202 15 5 0.333 0
CCR5 CCR5 P51681 C-C chemokine receptor type 5 chr3 GO:0000165 Not Cancer Driver No 107 0.304 0 0 0.0 0
DUSP5 DUSP5 Q16690 Dual specificity protein phosphatase 5 chr10 GO:0000165 Not Cancer Driver No 58 0.151 36 4 0.111 0
DUSP6 DUSP6 Q16828 Dual specificity protein phosphatase 6 chr12 GO:0000165 Not Cancer Driver No 43 0.113 39 3 0.077 4
DUSP7 DUSP7 Q16829 Dual specificity protein phosphatase 7 chr3 GO:0000165 Not Cancer Driver No 40 0.095 139 5 0.036 0
DUSP9 DUSP9 Q99956 Dual specificity protein phosphatase 9 chrX GO:0000165 Not Cancer Driver No 40 0.104 109 12 0.11 0
EGFR EGFR P00533 Epidermal growth factor receptor chr7 GO:0000165 Census, Compendium Yes 444 0.367 223 35 0.157 1
EPGN EPGN Q6UW88 Epigen chr4 GO:0000165 Not Cancer Driver No 16 0.104 0 0 0.0 0
FGF13_ENST00000315930 FGF13 Q92913 Fibroblast growth factor 13 chrX GO:0000165 Not Cancer Driver No 70 0.286 96 33 0.344 2
FGF23 FGF23 Q9GZV9 Fibroblast growth factor 23 chr12 GO:0000165 Not Cancer Driver No 84 0.335 97 51 0.526 7
FGF8_ENST00000344255 FGF8 P55075 Fibroblast growth factor 8 chr10 GO:0000165 Not Cancer Driver No 30 0.129 79 9 0.114 6
FGFR1_ENST00000447712 FGFR1 P11362 Fibroblast growth factor receptor 1 chr8 GO:0000165 Census, Compendium Yes 152 0.185 230 43 0.187 74
FGFR3_ENST00000440486 FGFR3 P22607 Fibroblast growth factor receptor 3 chr4 GO:0000165 Census, Compendium Yes 173 0.215 241 26 0.108 37
HRAS HRAS P01112 GTPase HRas chr11 GO:0000165 Census, Compendium Yes 107 0.566 16 4 0.25 18
HSF1 HSF1 Q00613 Heat shock factor protein 1 chr8 GO:0000165 Not Cancer Driver No 59 0.112 335 37 0.11 0
IL18 IL18 Q14116 Interleukin-18 chr11 GO:0000165 Not Cancer Driver No 19 0.098 16 3 0.188 0
IL1B IL1B P01584 Interleukin-1 beta chr2 GO:0000165 Not Cancer Driver No 39 0.145 16 3 0.188 0
IL31RA_ENST00000297015 IL31RA Q8NI17 Interleukin-31 receptor subunit alpha chr5 GO:0000165 Not Cancer Driver No 117 0.16 163 30 0.184 1
ITPKB_ENST00000272117 ITPKB P27987 Inositol-trisphosphate 3-kinase B chr1 GO:0000165 Not Cancer Driver No 148 0.156 719 119 0.166 0
KRAS KRAS P01116 GTPase KRas chr12 GO:0000165 Census, Compendium Yes 788 4.169 7 2 0.286 27
LGALS9 LGALS9 O00182 Galectin-9 chr17 GO:0000165 Not Cancer Driver No 54 0.152 65 16 0.246 0
LRRK2 LRRK2 Q5S007 Leucine-rich repeat serine/threonine-protein kinase 2 chr12 GO:0000165 Not Cancer Driver No 519 0.205 90 17 0.189 23
MAP2K1 MAP2K1 Q02750 Dual specificity mitogen-activated protein kinase kinase 1 chr15 GO:0000165 Census, Compendium Yes 94 0.239 96 24 0.25 6
MAP2K2 MAP2K2 P36507 Dual specificity mitogen-activated protein kinase kinase 2 chr19 GO:0000165 Census Yes 58 0.145 105 14 0.133 4
MAP2K3 MAP2K3 P46734 Dual specificity mitogen-activated protein kinase kinase 3 chr17 GO:0000165 Not Cancer Driver No 104 0.3 75 27 0.36 0
MAP2K4_ENST00000353533 MAP2K4 P45985 Dual specificity mitogen-activated protein kinase kinase 4 chr17 GO:0000165 Census, Compendium Yes 89 0.223 137 28 0.204 0
MAP2K5 MAP2K5 Q13163 Dual specificity mitogen-activated protein kinase kinase 5 chr15 GO:0000165 Not Cancer Driver No 40 0.089 85 10 0.118 0
MAP2K6 MAP2K6 P52564 Dual specificity mitogen-activated protein kinase kinase 6 chr17 GO:0000165 Not Cancer Driver No 48 0.144 55 11 0.2 0
MAP2K7_ENST00000397979 MAP2K7 O14733 Dual specificity mitogen-activated protein kinase kinase 7 chr19 GO:0000165 Compendium Yes 89 0.212 144 20 0.139 0
MAP3K1 MAP3K1 Q13233 Mitogen-activated protein kinase kinase kinase 1 chr5 GO:0000165 Census, Compendium Yes 184 0.122 820 62 0.076 3
MAP3K11 MAP3K11 Q16584 Mitogen-activated protein kinase kinase kinase 11 chr11 GO:0000165 Not Cancer Driver No 97 0.115 466 54 0.116 0
MAP3K14 MAP3K14 Q99558 Mitogen-activated protein kinase kinase kinase 14 chr17 GO:0000165 Not Cancer Driver No 94 0.099 543 52 0.096 0
MAP3K15 MAP3K15 Q6ZN16 Mitogen-activated protein kinase kinase kinase 15 chrX GO:0000165 Not Cancer Driver No 206 0.157 315 39 0.124 0
MAP3K20 MAP3K20 Q9NYL2 Mitogen-activated protein kinase kinase kinase 20 chr2 GO:0000165 Not Cancer Driver No 101 0.126 294 41 0.139 1
MAP3K21 MAP3K21 Q5TCX8 Mitogen-activated protein kinase kinase kinase 21 chr1 GO:0000165 Not Cancer Driver No 191 0.184 658 112 0.17 0
MAP3K2_ENST00000344908 MAP3K2 Q9Y2U5 Mitogen-activated protein kinase kinase kinase 2 chr2 GO:0000165 Not Cancer Driver No 75 0.121 313 47 0.15 0
MAP3K3_ENST00000361733 MAP3K3 Q99759 Mitogen-activated protein kinase kinase kinase 3 chr17 GO:0000165 Not Cancer Driver No 74 0.118 355 44 0.124 0
MAP3K4 MAP3K4 Q9Y6R4 Mitogen-activated protein kinase kinase kinase 4 chr6 GO:0000165 Not Cancer Driver No 261 0.162 520 86 0.165 0
MAP3K5 MAP3K5 Q99683 Mitogen-activated protein kinase kinase kinase 5 chr6 GO:0000165 Not Cancer Driver No 197 0.143 242 29 0.12 0
MAP3K6 MAP3K6 O95382 Mitogen-activated protein kinase kinase kinase 6 chr1 GO:0000165 Not Cancer Driver No 108 0.084 390 31 0.079 0
MAP3K7 MAP3K7 O43318 Mitogen-activated protein kinase kinase kinase 7 chr6 GO:0000165 Not Cancer Driver No 104 0.172 333 66 0.198 6
MAP3K8_ENST00000542547 MAP3K8 P41279 Mitogen-activated protein kinase kinase kinase 8 chr10 GO:0000165 Not Cancer Driver No 58 0.124 109 10 0.092 0
MAP3K9_ENST00000554752 MAP3K9 P80192 Mitogen-activated protein kinase kinase kinase 9 chr14 GO:0000165 Not Cancer Driver No 167 0.151 684 104 0.152 0
MAP4K4_ENST00000347699 MAP4K4 O95819 Mitogen-activated protein kinase kinase kinase kinase 4 chr2 GO:0000165 Not Cancer Driver No 143 0.115 649 55 0.085 0
MAP4K5 MAP4K5 Q9Y4K4 Mitogen-activated protein kinase kinase kinase kinase 5 chr14 GO:0000165 Not Cancer Driver No 69 0.082 236 23 0.097 0
MAPK11 MAPK11 Q15759 Mitogen-activated protein kinase 11 chr22 GO:0000165 Not Cancer Driver No 23 0.063 64 2 0.031 0
MAPK12 MAPK12 P53778 Mitogen-activated protein kinase 12 chr22 GO:0000165 Not Cancer Driver No 31 0.084 63 5 0.079 0
MAPK14_ENST00000229794 MAPK14 Q16539 Mitogen-activated protein kinase 14 chr6 GO:0000165 Not Cancer Driver No 39 0.108 25 1 0.04 0
MAPK15 MAPK15 Q8TD08 Mitogen-activated protein kinase 15 chr8 GO:0000165 Not Cancer Driver No 81 0.149 235 37 0.157 0
MAPK3 MAPK3 P27361 Mitogen-activated protein kinase 3 chr16 GO:0000165 Not Cancer Driver No 38 0.1 49 5 0.102 0
MAPK4 MAPK4 P31152 Mitogen-activated protein kinase 4 chr18 GO:0000165 Not Cancer Driver No 111 0.189 222 42 0.189 0
MAPK6 MAPK6 Q16659 Mitogen-activated protein kinase 6 chr15 GO:0000165 Not Cancer Driver No 79 0.11 165 20 0.121 0
MAPK7 MAPK7 Q13164 Mitogen-activated protein kinase 7 chr17 GO:0000165 Not Cancer Driver No 92 0.113 490 50 0.102 0
MAPKAPK2 MAPKAPK2 P49137 MAP kinase-activated protein kinase 2 chr1 GO:0000165 Not Cancer Driver No 43 0.107 92 5 0.054 0
MAPKAPK3 MAPKAPK3 Q16644 MAP kinase-activated protein kinase 3 chr3 GO:0000165 Not Cancer Driver No 35 0.092 117 12 0.103 1
MAPKAPK5 MAPKAPK5 Q8IW41 MAP kinase-activated protein kinase 5 chr12 GO:0000165 Not Cancer Driver No 51 0.108 101 12 0.119 0
MBP_ENST00000580402 MBP P02686 Myelin basic protein chr18 GO:0000165 Not Cancer Driver No 52 0.171 304 52 0.171 0
MEF2A_ENST00000354410 MEF2A Q02078 Myocyte-specific enhancer factor 2A chr15 GO:0000165 Not Cancer Driver No 62 0.122 454 56 0.123 0
MEF2C_ENST00000504921 MEF2C Q06413 Myocyte-specific enhancer factor 2C chr5 GO:0000165 Not Cancer Driver No 92 0.195 408 81 0.199 0
MEN1 MEN1 O00255 Menin chr11 GO:0000165 Census, Compendium Yes 73 0.119 228 15 0.066 90
MINK1 MINK1 Q8N4C8 Misshapen-like kinase 1 chr17 GO:0000165 Not Cancer Driver No 113 0.085 740 56 0.076 0
MLKL MLKL Q8NB16 Mixed lineage kinase domain-like protein chr16 GO:0000165 Not Cancer Driver No 56 0.119 89 15 0.169 0
MOS MOS P00540 Proto-oncogene serine/threonine-protein kinase mos chr8 GO:0000165 Not Cancer Driver No 94 0.272 16 4 0.25 0
MYC_ENST00000377970 MYC P01106 Myc proto-oncogene protein chr8 GO:0000165 Census, Compendium Yes 80 0.182 299 46 0.154 0
NF1 NF1 P21359 Neurofibromin chr17 GO:0000165 Census, Compendium Yes 375 0.132 406 47 0.116 85
NLK NLK Q9UBE8 Serine/threonine-protein kinase NLK chr17 GO:0000165 Not Cancer Driver No 54 0.102 152 20 0.132 0
NRAS NRAS P01111 GTPase NRas chr1 GO:0000165 Census, Compendium Yes 284 1.503 10 0 0.0 14
NRG1_ENST00000405005 NRG1 Q02297 Pro-neuregulin-1, membrane-bound isoform chr8 GO:0000165 Census, Compendium Yes 159 0.248 528 132 0.25 0
NRK NRK Q7Z2Y5 Nik-related protein kinase chrX GO:0000165 Compendium Yes 315 0.199 812 159 0.196 0
NRTN NRTN Q99748 Neurturin chr19 GO:0000165 Not Cancer Driver No 7 0.036 26 0 0.0 0
PABPN1 PABPN1 Q86U42 Polyadenylate-binding protein 2 chr14 GO:0000165 Not Cancer Driver No 27 0.088 241 18 0.075 0
PAK1_ENST00000356341 PAK1 Q13153 Serine/threonine-protein kinase PAK 1 chr11 GO:0000165 Not Cancer Driver No 57 0.105 299 30 0.1 2
PAK3_ENST00000262836 PAK3 O75914 Serine/threonine-protein kinase PAK 3 chrX GO:0000165 Not Cancer Driver No 127 0.227 286 64 0.224 2
PBK_ENST00000301905 PBK Q96KB5 Lymphokine-activated killer T-cell-originated protein kinase chr8 GO:0000165 Not Cancer Driver No 23 0.071 92 6 0.065 0
PEA15_ENST00000360472 PEA15 Q15121 Astrocytic phosphoprotein PEA-15 chr1 GO:0000165 Not Cancer Driver No 12 0.092 35 5 0.143 0
PLVAP PLVAP Q9BX97 Plasmalemma vesicle-associated protein chr19 GO:0000165 Not Cancer Driver No 96 0.217 174 39 0.224 1
POU4F2 POU4F2 Q12837 POU domain, class 4, transcription factor 2 chr4 GO:0000165 Not Cancer Driver No 130 0.318 308 87 0.282 0
PPM1L PPM1L Q5SGD2 Protein phosphatase 1L chr3 GO:0000165 Not Cancer Driver No 67 0.186 25 2 0.08 0
PPP1CB_ENST00000358506 PPP1CB P62140 Serine/threonine-protein phosphatase PP1-beta catalytic subunit chr2 GO:0000165 Not Cancer Driver No 47 0.144 25 5 0.2 5
PPP1CC_ENST00000335007 PPP1CC P36873 Serine/threonine-protein phosphatase PP1-gamma catalytic subunit chr12 GO:0000165 Not Cancer Driver No 26 0.08 23 4 0.174 0
PPP5C PPP5C P53041 Serine/threonine-protein phosphatase 5 chr19 GO:0000165 Not Cancer Driver No 70 0.14 73 12 0.164 0
PTK2B_ENST00000346049 PTK2B Q14289 Protein-tyrosine kinase 2-beta chr8 GO:0000165 Not Cancer Driver No 161 0.16 261 37 0.142 0
PTPN3 PTPN3 P26045 Tyrosine-protein phosphatase non-receptor type 3 chr9 GO:0000165 Not Cancer Driver No 139 0.152 214 28 0.131 0
RAF1 RAF1 P04049 RAF proto-oncogene serine/threonine-protein kinase chr3 GO:0000165 Census, Compendium Yes 89 0.137 169 38 0.225 22
RAPGEF2 RAPGEF2 Q9Y4G8 Rap guanine nucleotide exchange factor 2 chr4 GO:0000165 Not Cancer Driver No 216 0.144 803 116 0.144 0
RASGRP3_ENST00000402538 RASGRP3 Q8IV61 Ras guanyl-releasing protein 3 chr2 GO:0000165 Not Cancer Driver No 119 0.172 145 20 0.138 0
RBX1 RBX1 P62877 E3 ubiquitin-protein ligase RBX1 chr22 GO:0000165 Not Cancer Driver No 10 0.093 18 1 0.056 0
RCE1 RCE1 Q9Y256 CAAX prenyl protease 2 chr11 GO:0000165 Not Cancer Driver No 40 0.122 0 0 0.0 0
RET RET P07949 Proto-oncogene tyrosine-protein kinase receptor Ret chr10 GO:0000165 Census, Compendium Yes 208 0.187 105 12 0.114 139
RHBDD3 RHBDD3 Q9Y3P4 Rhomboid domain-containing protein 3 chr22 GO:0000165 Not Cancer Driver No 24 0.062 147 16 0.109 0
RIPK1_ENST00000380409 RIPK1 Q13546 Receptor-interacting serine/threonine-protein kinase 1 chr6 GO:0000165 Compendium Yes 82 0.122 277 39 0.141 4
RIPK2 RIPK2 O43353 Receptor-interacting serine/threonine-protein kinase 2 chr8 GO:0000165 Not Cancer Driver No 63 0.117 143 20 0.14 0
RIT2 RIT2 Q99578 GTP-binding protein Rit2 chr18 GO:0000165 Not Cancer Driver No 74 0.341 29 11 0.379 0
SBK2_ENST00000344158 SBK2 P0C263 Serine/threonine-protein kinase SBK2 chr19 GO:0000165 Not Cancer Driver No 67 0.193 73 13 0.178 0
SCG2 SCG2 P13521 Secretogranin-2 chr2 GO:0000165 Not Cancer Driver No 116 0.188 531 103 0.194 0
SETX SETX Q7Z333 Probable helicase senataxin chr9 GO:0000165 Not Cancer Driver No 342 0.128 1240 156 0.126 20
SMAD1 SMAD1 Q15797 Mothers against decapentaplegic homolog 1 chr4 GO:0000165 Not Cancer Driver No 54 0.116 161 22 0.137 0
TAOK1 TAOK1 Q7L7X3 Serine/threonine-protein kinase TAO1 chr17 GO:0000165 Not Cancer Driver No 116 0.116 601 59 0.098 0
TAOK2 TAOK2 Q9UL54 Serine/threonine-protein kinase TAO2 chr16 GO:0000165 Not Cancer Driver No 191 0.155 666 102 0.153 0
TAOK3 TAOK3 Q9H2K8 Serine/threonine-protein kinase TAO3 chr12 GO:0000165 Not Cancer Driver No 123 0.137 494 64 0.13 0
TGFB1 TGFB1 P01137 Transforming growth factor beta-1 proprotein chr19 GO:0000165 Not Cancer Driver No 41 0.105 41 4 0.098 10
TNF TNF P01375 Tumor necrosis factor chr6 GO:0000165 Not Cancer Driver No 24 0.103 45 3 0.067 0
TNIK TNIK Q9UKE5 TRAF2 and NCK-interacting protein kinase chr3 GO:0000165 Not Cancer Driver No 254 0.187 781 156 0.2 0
USP17L2 USP17L2 Q6R6M4 Ubiquitin carboxyl-terminal hydrolase 17 chr8 GO:0000165 Not Cancer Driver No 105 0.198 201 54 0.269 0
YWHAE YWHAE P62258 14-3-3 protein epsilon chr17 GO:0000165 Census Yes 32 0.125 41 3 0.073 0
ZDHHC9_ENST00000371064 ZDHHC9 Q9Y397 Palmitoyltransferase ZDHHC9 chrX GO:0000165 Not Cancer Driver No 52 0.143 84 6 0.071 2
ZFP36 ZFP36 P26651 mRNA decay activator protein ZFP36 chr19 GO:0000165 Not Cancer Driver No 43 0.132 262 34 0.13 0
ZFP36L1 ZFP36L1 Q07352 mRNA decay activator protein ZFP36L1 chr14 GO:0000165 Compendium Yes 57 0.169 212 30 0.142 0