Total number of protein in "GO:0000077" GO term: 60
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ATM_ENST00000452508 | ATM | Q13315 | Serine-protein kinase ATM | chr11 | GO:0000077 | Census, Compendium | Yes | 469 | 0.153 | 225 | 39 | 0.173 | 41 |
| ATR | ATR | Q13535 | Serine/threonine-protein kinase ATR | chr3 | GO:0000077 | Census, Compendium | Yes | 338 | 0.128 | 106 | 14 | 0.132 | 1 |
| ATRIP | ATRIP | Q8WXE1 | ATR-interacting protein | chr3 | GO:0000077 | Not Cancer Driver | No | 76 | 0.096 | 383 | 32 | 0.084 | 0 |
| BRIP1 | BRIP1 | Q9BX63 | Fanconi anemia group J protein | chr17 | GO:0000077 | Census | Yes | 174 | 0.139 | 397 | 59 | 0.149 | 6 |
| CASP2 | CASP2 | P42575 | Caspase-2 | chr7 | GO:0000077 | Not Cancer Driver | No | 63 | 0.139 | 42 | 12 | 0.286 | 0 |
| CCND1 | CCND1 | P24385 | G1/S-specific cyclin-D1 | chr11 | GO:0000077 | Census, Compendium | Yes | 55 | 0.186 | 31 | 25 | 0.806 | 0 |
| CDC5L | CDC5L | Q99459 | Cell division cycle 5-like protein | chr6 | GO:0000077 | Not Cancer Driver | No | 100 | 0.125 | 618 | 77 | 0.125 | 0 |
| CDK2 | CDK2 | P24941 | Cyclin-dependent kinase 2 | chr12 | GO:0000077 | Not Cancer Driver | No | 24 | 0.081 | 0 | 0 | 0.0 | 0 |
| CDKN1A_ENST00000373711 | CDKN1A | P38936 | Cyclin-dependent kinase inhibitor 1 | chr6 | GO:0000077 | Census, Compendium | Yes | 48 | 0.293 | 121 | 30 | 0.248 | 0 |
| CDKN1B | CDKN1B | P46527 | Cyclin-dependent kinase inhibitor 1B | chr12 | GO:0000077 | Census, Compendium | Yes | 19 | 0.096 | 198 | 19 | 0.096 | 0 |
| CEP63 | CEP63 | Q96MT8 | Centrosomal protein of 63 kDa | chr3 | GO:0000077 | Not Cancer Driver | No | 100 | 0.142 | 507 | 68 | 0.134 | 0 |
| CHEK1_ENST00000428830 | CHEK1 | O14757 | Serine/threonine-protein kinase Chk1 | chr11 | GO:0000077 | Not Cancer Driver | No | 58 | 0.122 | 86 | 16 | 0.186 | 0 |
| CHEK2_ENST00000405598 | CHEK2 | O96017 | Serine/threonine-protein kinase Chk2 | chr22 | GO:0000077 | Census, Compendium | Yes | 335 | 0.617 | 157 | 130 | 0.828 | 13 |
| CLOCK | CLOCK | O15516 | Circadian locomoter output cycles protein kaput | chr4 | GO:0000077 | Not Cancer Driver | No | 83 | 0.098 | 458 | 38 | 0.083 | 0 |
| CLSPN | CLSPN | Q9HAW4 | Claspin | chr1 | GO:0000077 | Not Cancer Driver | No | 151 | 0.113 | 1283 | 147 | 0.115 | 0 |
| CRADD_ENST00000332896 | CRADD | P78560 | Death domain-containing protein CRADD | chr12 | GO:0000077 | Not Cancer Driver | No | 35 | 0.176 | 45 | 5 | 0.111 | 1 |
| DONSON | DONSON | Q9NYP3 | Protein downstream neighbor of Son | chr21 | GO:0000077 | Not Cancer Driver | No | 50 | 0.088 | 217 | 13 | 0.06 | 6 |
| DOT1L | DOT1L | Q8TEK3 | Histone-lysine N-methyltransferase, H3 lysine-79 specific | chr19 | GO:0000077 | Compendium | Yes | 178 | 0.116 | 988 | 118 | 0.119 | 0 |
| E2F1 | E2F1 | Q01094 | Transcription factor E2F1 | chr20 | GO:0000077 | Not Cancer Driver | No | 49 | 0.112 | 272 | 23 | 0.085 | 0 |
| EIF2AK4 | EIF2AK4 | Q9P2K8 | eIF-2-alpha kinase GCN2 | chr15 | GO:0000077 | Not Cancer Driver | No | 156 | 0.095 | 494 | 44 | 0.089 | 2 |
| ERCC6 | ERCC6 | Q03468 | DNA excision repair protein ERCC-6 | chr10 | GO:0000077 | Not Cancer Driver | No | 211 | 0.141 | 829 | 117 | 0.141 | 9 |
| FBXO31 | FBXO31 | Q5XUX0 | F-box only protein 31 | chr16 | GO:0000077 | Not Cancer Driver | No | 72 | 0.134 | 231 | 30 | 0.13 | 0 |
| FBXO6 | FBXO6 | Q9NRD1 | F-box only protein 6 | chr1 | GO:0000077 | Not Cancer Driver | No | 31 | 0.106 | 27 | 3 | 0.111 | 0 |
| GIGYF2_ENST00000409547 | GIGYF2 | Q6Y7W6 | GRB10-interacting GYF protein 2 | chr2 | GO:0000077 | Not Cancer Driver | No | 176 | 0.135 | 1096 | 158 | 0.144 | 6 |
| GML | GML | Q99445 | Glycosyl-phosphatidylinositol-anchored molecule-like protein | chr8 | GO:0000077 | Not Cancer Driver | No | 49 | 0.31 | 12 | 6 | 0.5 | 0 |
| GTSE1 | GTSE1 | Q9NYZ3 | G2 and S phase-expressed protein 1 | chr22 | GO:0000077 | Not Cancer Driver | No | 91 | 0.126 | 660 | 85 | 0.129 | 0 |
| H2AFX | H2AX | P16104 | Histone H2AX | chr11 | GO:0000077 | Not Cancer Driver | No | 20 | 0.14 | 68 | 10 | 0.147 | 0 |
| HINFP | HINFP | Q9BQA5 | Histone H4 transcription factor | chr11 | GO:0000077 | Not Cancer Driver | No | 65 | 0.126 | 154 | 24 | 0.156 | 0 |
| HUS1 | HUS1 | O60921 | Checkpoint protein HUS1 | chr7 | GO:0000077 | Not Cancer Driver | No | 25 | 0.089 | 17 | 2 | 0.118 | 0 |
| INTS7 | INTS7 | Q9NVH2 | Integrator complex subunit 7 | chr1 | GO:0000077 | Not Cancer Driver | No | 106 | 0.11 | 88 | 17 | 0.193 | 0 |
| MAP3K20 | MAP3K20 | Q9NYL2 | Mitogen-activated protein kinase kinase kinase 20 | chr2 | GO:0000077 | Not Cancer Driver | No | 101 | 0.126 | 294 | 41 | 0.139 | 1 |
| MAPK14_ENST00000229794 | MAPK14 | Q16539 | Mitogen-activated protein kinase 14 | chr6 | GO:0000077 | Not Cancer Driver | No | 39 | 0.108 | 25 | 1 | 0.04 | 0 |
| MDM2_ENST00000539479 | MDM2 | Q00987 | E3 ubiquitin-protein ligase Mdm2 | chr12 | GO:0000077 | Census, Compendium | Yes | 56 | 0.114 | 297 | 37 | 0.125 | 0 |
| MUC1_ENST00000611571 | MUC1 | P15941 | Mucin-1 | chr1 | GO:0000077 | Census | Yes | 40 | 0.032 | 1050 | 19 | 0.018 | 0 |
| NBN | NBN | O60934 | Nibrin | chr8 | GO:0000077 | Census | Yes | 90 | 0.119 | 417 | 54 | 0.129 | 1 |
| PIDD1 | PIDD1 | Q9HB75 | p53-induced death domain-containing protein 1 | chr11 | GO:0000077 | Not Cancer Driver | No | 93 | 0.102 | 137 | 14 | 0.102 | 0 |
| PLK2 | PLK2 | Q9NYY3 | Serine/threonine-protein kinase PLK2 | chr5 | GO:0000077 | Not Cancer Driver | No | 92 | 0.134 | 178 | 21 | 0.118 | 0 |
| PLK3 | PLK3 | Q9H4B4 | Serine/threonine-protein kinase PLK3 | chr1 | GO:0000077 | Not Cancer Driver | No | 75 | 0.116 | 202 | 15 | 0.074 | 0 |
| PML | PML | P29590 | Protein PML | chr15 | GO:0000077 | Census, Compendium | Yes | 112 | 0.127 | 312 | 34 | 0.109 | 0 |
| PRAP1 | PRAP1 | Q96NZ9 | Proline-rich acidic protein 1 | chr10 | GO:0000077 | Not Cancer Driver | No | 14 | 0.093 | 124 | 13 | 0.105 | 0 |
| PRKDC | PRKDC | P78527 | DNA-dependent protein kinase catalytic subunit | chr8 | GO:0000077 | Not Cancer Driver | No | 538 | 0.13 | 421 | 61 | 0.145 | 2 |
| PRPF19 | PRPF19 | Q9UMS4 | Pre-mRNA-processing factor 19 | chr11 | GO:0000077 | Not Cancer Driver | No | 71 | 0.141 | 109 | 16 | 0.147 | 0 |
| PTPN11_ENST00000351677 | PTPN11 | Q06124 | Tyrosine-protein phosphatase non-receptor type 11 | chr12 | GO:0000077 | Census, Compendium | Yes | 129 | 0.218 | 260 | 38 | 0.146 | 60 |
| RAD1 | RAD1 | O60671 | Cell cycle checkpoint protein RAD1 | chr5 | GO:0000077 | Not Cancer Driver | No | 29 | 0.103 | 4 | 1 | 0.25 | 0 |
| RAD17 | RAD17 | O75943 | Cell cycle checkpoint protein RAD17 | chr5 | GO:0000077 | Census | Yes | 78 | 0.115 | 207 | 19 | 0.092 | 0 |
| RAD9A | RAD9A | Q99638 | Cell cycle checkpoint control protein RAD9A | chr11 | GO:0000077 | Not Cancer Driver | No | 34 | 0.087 | 135 | 7 | 0.052 | 0 |
| RFWD3 | RFWD3 | Q6PCD5 | E3 ubiquitin-protein ligase RFWD3 | chr16 | GO:0000077 | Census | Yes | 68 | 0.088 | 318 | 30 | 0.094 | 1 |
| RHNO1 | RHNO1 | Q9BSD3 | RAD9, HUS1, RAD1-interacting nuclear orphan protein 1 | chr12 | GO:0000077 | Not Cancer Driver | No | 26 | 0.109 | 193 | 21 | 0.109 | 0 |
| RPA2_ENST00000373912 | RPA2 | P15927 | Replication protein A 32 kDa subunit | chr1 | GO:0000077 | Not Cancer Driver | No | 28 | 0.104 | 114 | 16 | 0.14 | 0 |
| RPA4 | RPA4 | Q13156 | Replication protein A 30 kDa subunit | chrX | GO:0000077 | Not Cancer Driver | No | 66 | 0.253 | 58 | 15 | 0.259 | 0 |
| RPL26 | RPL26 | P61254 | 60S ribosomal protein L26 | chr17 | GO:0000077 | Not Cancer Driver | No | 16 | 0.11 | 114 | 13 | 0.114 | 0 |
| RPS27L | RPS27L | Q71UM5 | 40S ribosomal protein S27-like | chr15 | GO:0000077 | Not Cancer Driver | No | 4 | 0.048 | 22 | 2 | 0.091 | 0 |
| SDE2 | SDE2 | Q6IQ49 | Replication stress response regulator SDE2 | chr1 | GO:0000077 | Not Cancer Driver | No | 56 | 0.124 | 290 | 35 | 0.121 | 0 |
| TIPRL | TIPRL | O75663 | TIP41-like protein | chr1 | GO:0000077 | Not Cancer Driver | No | 25 | 0.092 | 25 | 3 | 0.12 | 0 |
| TP53BP1_ENST00000263801 | TP53BP1 | Q12888 | TP53-binding protein 1 | chr15 | GO:0000077 | Not Cancer Driver | No | 227 | 0.115 | 1632 | 190 | 0.116 | 0 |
| TP53_ENST00000445888 | TP53 | P04637 | Cellular tumor antigen p53 | chr17 | GO:0000077 | Census, Compendium | Yes | 2891 | 7.356 | 282 | 1466 | 5.199 | 83 |
| TREX1_ENST00000625293 | TREX1 | Q9NSU2 | Three-prime repair exonuclease 1 | chr3 | GO:0000077 | Not Cancer Driver | No | 26 | 0.083 | 98 | 10 | 0.102 | 18 |
| TRIAP1 | TRIAP1 | O43715 | TP53-regulated inhibitor of apoptosis 1 | chr12 | GO:0000077 | Not Cancer Driver | No | 9 | 0.118 | 20 | 1 | 0.05 | 0 |
| USP28 | USP28 | Q96RU2 | Ubiquitin carboxyl-terminal hydrolase 28 | chr11 | GO:0000077 | Not Cancer Driver | No | 151 | 0.14 | 311 | 25 | 0.08 | 0 |
| WAC | WAC | Q9BTA9 | WW domain-containing adapter protein with coiled-coil | chr10 | GO:0000077 | Not Cancer Driver | No | 106 | 0.164 | 571 | 95 | 0.166 | 0 |