Total number of protein in "GO:0000018" GO term: 90
| Identifier | UniProt Gene | UniProt Accession | UniProt Name | Chromosome | GO term | Database | Cancer Driver | Number of missense mutations | Missense mutation per residues | Number of disordered residues | Number of mutations in disordered regions | Disordered missense mutations per residues | Number of OMIM mutation |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| ACTB_ENST00000646664 | ACTB | P60709 | Actin, cytoplasmic 1 | chr7 | GO:0000018 | Not Cancer Driver | No | 112 | 0.299 | 43 | 5 | 0.116 | 5 |
| ACTL6A | ACTL6A | O96019 | Actin-like protein 6A | chr3 | GO:0000018 | Not Cancer Driver | No | 61 | 0.142 | 74 | 15 | 0.203 | 0 |
| ACTR2_ENST00000260641 | ACTR2 | P61160 | Actin-related protein 2 | chr2 | GO:0000018 | Not Cancer Driver | No | 51 | 0.129 | 6 | 2 | 0.333 | 0 |
| ALYREF | ALYREF | Q86V81 | THO complex subunit 4 | chr17 | GO:0000018 | Not Cancer Driver | No | 32 | 0.125 | 223 | 26 | 0.117 | 0 |
| APLF | APLF | Q8IW19 | Aprataxin and PNK-like factor | chr2 | GO:0000018 | Not Cancer Driver | No | 64 | 0.125 | 407 | 57 | 0.14 | 0 |
| ARID2 | ARID2 | Q68CP9 | AT-rich interactive domain-containing protein 2 | chr12 | GO:0000018 | Census, Compendium | Yes | 272 | 0.148 | 1143 | 141 | 0.123 | 0 |
| ATAD5 | ATAD5 | Q96QE3 | ATPase family AAA domain-containing protein 5 | chr17 | GO:0000018 | Not Cancer Driver | No | 200 | 0.108 | 1075 | 112 | 0.104 | 0 |
| BCL6_ENST00000232014 | BCL6 | P41182 | B-cell lymphoma 6 protein | chr3 | GO:0000018 | Census, Compendium | Yes | 134 | 0.19 | 328 | 67 | 0.204 | 0 |
| BRD8 | BRD8 | Q9H0E9 | Bromodomain-containing protein 8 | chr5 | GO:0000018 | Not Cancer Driver | No | 189 | 0.153 | 934 | 147 | 0.157 | 0 |
| CD28 | CD28 | P10747 | T-cell-specific surface glycoprotein CD28 | chr2 | GO:0000018 | Census | Yes | 42 | 0.191 | 18 | 10 | 0.556 | 0 |
| CD40 | CD40 | P25942 | Tumor necrosis factor receptor superfamily member 5 | chr20 | GO:0000018 | Not Cancer Driver | No | 39 | 0.141 | 56 | 6 | 0.107 | 2 |
| CLCF1 | CLCF1 | Q9UBD9 | Cardiotrophin-like cytokine factor 1 | chr11 | GO:0000018 | Not Cancer Driver | No | 22 | 0.098 | 42 | 4 | 0.095 | 1 |
| DMAP1_ENST00000315913 | DMAP1 | Q9NPF5 | DNA methyltransferase 1-associated protein 1 | chr1 | GO:0000018 | Not Cancer Driver | No | 49 | 0.105 | 269 | 28 | 0.104 | 0 |
| EP400 | EP400 | Q96L91 | E1A-binding protein p400 | chr12 | GO:0000018 | Not Cancer Driver | No | 397 | 0.126 | 2064 | 234 | 0.113 | 0 |
| EPC1 | EPC1 | Q9H2F5 | Enhancer of polycomb homolog 1 | chr10 | GO:0000018 | Not Cancer Driver | No | 104 | 0.124 | 515 | 68 | 0.132 | 0 |
| EPC2 | EPC2 | Q52LR7 | Enhancer of polycomb homolog 2 | chr2 | GO:0000018 | Not Cancer Driver | No | 95 | 0.118 | 583 | 67 | 0.115 | 0 |
| ERCC2 | ERCC2 | P18074 | General transcription and DNA repair factor IIH helicase subunit XPD | chr19 | GO:0000018 | Census, Compendium | Yes | 150 | 0.197 | 5 | 0 | 0.0 | 35 |
| ERCC6 | ERCC6 | Q03468 | DNA excision repair protein ERCC-6 | chr10 | GO:0000018 | Not Cancer Driver | No | 211 | 0.141 | 829 | 117 | 0.141 | 9 |
| EXOSC3 | EXOSC3 | Q9NQT5 | Exosome complex component RRP40 | chr9 | GO:0000018 | Not Cancer Driver | No | 18 | 0.065 | 54 | 2 | 0.037 | 4 |
| EXOSC6 | EXOSC6 | Q5RKV6 | Exosome complex component MTR3 | chr16 | GO:0000018 | Not Cancer Driver | No | 3 | 0.011 | 102 | 0 | 0.0 | 0 |
| FANCB | FANCB | Q8NB91 | Fanconi anemia group B protein | chrX | GO:0000018 | Not Cancer Driver | No | 109 | 0.127 | 24 | 5 | 0.208 | 0 |
| FOXP3 | FOXP3 | Q9BZS1 | Forkhead box protein P3 | chrX | GO:0000018 | Not Cancer Driver | No | 38 | 0.088 | 186 | 16 | 0.086 | 10 |
| FUS | FUS | P35637 | RNA-binding protein FUS | chr16 | GO:0000018 | Census | Yes | 51 | 0.097 | 524 | 51 | 0.097 | 20 |
| HDGFL2 | HDGFL2 | Q7Z4V5 | Hepatoma-derived growth factor-related protein 2 | chr19 | GO:0000018 | Not Cancer Driver | No | 59 | 0.088 | 622 | 57 | 0.092 | 0 |
| HMCES_ENST00000502878 | HMCES | Q96FZ2 | Abasic site processing protein HMCES | chr3 | GO:0000018 | Not Cancer Driver | No | 37 | 0.105 | 131 | 16 | 0.122 | 0 |
| IL10 | IL10 | P22301 | Interleukin-10 | chr1 | GO:0000018 | Not Cancer Driver | No | 19 | 0.107 | 23 | 1 | 0.043 | 0 |
| IL2 | IL2 | P60568 | Interleukin-2 | chr4 | GO:0000018 | Census | Yes | 24 | 0.157 | 6 | 1 | 0.167 | 0 |
| IL27RA | IL27RA | Q6UWB1 | Interleukin-27 receptor subunit alpha | chr19 | GO:0000018 | Not Cancer Driver | No | 91 | 0.143 | 167 | 23 | 0.138 | 0 |
| IL4 | IL4 | P05112 | Interleukin-4 | chr5 | GO:0000018 | Not Cancer Driver | No | 18 | 0.118 | 0 | 0 | 0.0 | 0 |
| IL7R | IL7R | P16871 | Interleukin-7 receptor subunit alpha | chr5 | GO:0000018 | Census, Compendium | Yes | 177 | 0.386 | 88 | 48 | 0.545 | 1 |
| ING3 | ING3 | Q9NXR8 | Inhibitor of growth protein 3 | chr7 | GO:0000018 | Not Cancer Driver | No | 44 | 0.105 | 292 | 32 | 0.11 | 1 |
| KAT5_ENST00000377046 | KAT5 | Q92993 | Histone acetyltransferase KAT5 | chr11 | GO:0000018 | Not Cancer Driver | No | 65 | 0.127 | 173 | 21 | 0.121 | 3 |
| KHDC3L | KHDC3L | Q587J8 | KH domain-containing protein 3 | chr6 | GO:0000018 | Not Cancer Driver | No | 68 | 0.313 | 121 | 43 | 0.355 | 0 |
| KMT5B_ENST00000615954 | KMT5B | Q4FZB7 | Histone-lysine N-methyltransferase KMT5B | chr11 | GO:0000018 | Not Cancer Driver | No | 147 | 0.166 | 659 | 113 | 0.171 | 0 |
| KMT5C | KMT5C | Q86Y97 | Histone-lysine N-methyltransferase KMT5C | chr19 | GO:0000018 | Not Cancer Driver | No | 37 | 0.08 | 142 | 9 | 0.063 | 0 |
| KPNA1 | KPNA1 | P52294 | Importin subunit alpha-5 | chr3 | GO:0000018 | Not Cancer Driver | No | 65 | 0.121 | 121 | 18 | 0.149 | 0 |
| KPNA2_ENST00000330459 | KPNA2 | P52292 | Importin subunit alpha-1 | chr17 | GO:0000018 | Not Cancer Driver | No | 74 | 0.14 | 129 | 18 | 0.14 | 0 |
| MAD2L2 | MAD2L2 | Q9UI95 | Mitotic spindle assembly checkpoint protein MAD2B | chr1 | GO:0000018 | Not Cancer Driver | No | 22 | 0.104 | 0 | 0 | 0.0 | 1 |
| MBTD1_ENST00000415868 | MBTD1 | Q05BQ5 | MBT domain-containing protein 1 | chr17 | GO:0000018 | Not Cancer Driver | No | 66 | 0.105 | 119 | 8 | 0.067 | 0 |
| MEAF6_ENST00000296214 | MEAF6 | Q9HAF1 | Chromatin modification-related protein MEAF6 | chr1 | GO:0000018 | Not Cancer Driver | No | 22 | 0.115 | 171 | 21 | 0.123 | 0 |
| MLH1 | MLH1 | P40692 | DNA mismatch repair protein Mlh1 | chr3 | GO:0000018 | Census | Yes | 92 | 0.122 | 208 | 22 | 0.106 | 85 |
| MMS19 | MMS19 | Q96T76 | MMS19 nucleotide excision repair protein homolog | chr10 | GO:0000018 | Not Cancer Driver | No | 73 | 0.071 | 11 | 0 | 0.0 | 0 |
| MORF4L1 | MORF4L1 | Q9UBU8 | Mortality factor 4-like protein 1 | chr15 | GO:0000018 | Not Cancer Driver | No | 43 | 0.119 | 163 | 17 | 0.104 | 0 |
| MORF4L2_ENST00000433176 | MORF4L2 | Q15014 | Mortality factor 4-like protein 2 | chrX | GO:0000018 | Not Cancer Driver | No | 44 | 0.153 | 136 | 21 | 0.154 | 0 |
| MRE11 | MRE11 | P49959 | Double-strand break repair protein MRE11 | chr11 | GO:0000018 | Not Cancer Driver | No | 84 | 0.119 | 292 | 35 | 0.12 | 1 |
| MRGBP | MRGBP | Q9NV56 | MRG/MORF4L-binding protein | chr20 | GO:0000018 | Not Cancer Driver | No | 27 | 0.132 | 147 | 23 | 0.156 | 0 |
| MRNIP | MRNIP | Q6NTE8 | MRN complex-interacting protein | chr5 | GO:0000018 | Not Cancer Driver | No | 44 | 0.128 | 268 | 35 | 0.131 | 0 |
| MSH2 | MSH2 | P43246 | DNA mismatch repair protein Msh2 | chr2 | GO:0000018 | Census | Yes | 92 | 0.099 | 37 | 4 | 0.108 | 70 |
| NDFIP1 | NDFIP1 | Q9BT67 | NEDD4 family-interacting protein 1 | chr5 | GO:0000018 | Not Cancer Driver | No | 22 | 0.1 | 44 | 4 | 0.091 | 0 |
| NSD2_ENST00000382892 | NSD2 | O96028 | Histone-lysine N-methyltransferase NSD2 | chr4 | GO:0000018 | Census, Compendium | Yes | 191 | 0.14 | 552 | 76 | 0.138 | 0 |
| OOEP | OOEP | A6NGQ2 | Oocyte-expressed protein homolog | chr6 | GO:0000018 | Not Cancer Driver | No | 46 | 0.309 | 48 | 14 | 0.292 | 0 |
| PARP1 | PARP1 | P09874 | Poly [ADP-ribose] polymerase 1 | chr1 | GO:0000018 | Not Cancer Driver | No | 119 | 0.117 | 320 | 34 | 0.106 | 0 |
| PARP3_ENST00000431474 | PARP3 | Q9Y6F1 | Protein mono-ADP-ribosyltransferase PARP3 | chr3 | GO:0000018 | Not Cancer Driver | No | 70 | 0.131 | 269 | 38 | 0.141 | 0 |
| PAXIP1 | PAXIP1 | Q6ZW49 | PAX-interacting protein 1 | chr7 | GO:0000018 | Not Cancer Driver | No | 120 | 0.112 | 461 | 39 | 0.085 | 0 |
| POGZ | POGZ | Q7Z3K3 | Pogo transposable element with ZNF domain | chr1 | GO:0000018 | Not Cancer Driver | No | 157 | 0.111 | 746 | 78 | 0.105 | 0 |
| PRDM7_ENST00000449207 | PRDM7 | Q9NQW5 | Histone-lysine N-methyltransferase PRDM7 | chr16 | GO:0000018 | Not Cancer Driver | No | 62 | 0.126 | 280 | 26 | 0.093 | 0 |
| PRDM9 | PRDM9 | Q9NQV7 | Histone-lysine N-methyltransferase PRDM9 | chr5 | GO:0000018 | Not Cancer Driver | No | 494 | 0.553 | 372 | 201 | 0.54 | 0 |
| PTPRC | PTPRC | P08575 | Receptor-type tyrosine-protein phosphatase C | chr1 | GO:0000018 | Census, Compendium | Yes | 315 | 0.241 | 462 | 107 | 0.232 | 0 |
| RAD50 | RAD50 | Q92878 | DNA repair protein RAD50 | chr5 | GO:0000018 | Not Cancer Driver | No | 157 | 0.12 | 730 | 84 | 0.115 | 0 |
| RAD51AP1 | RAD51AP1 | Q96B01 | RAD51-associated protein 1 | chr12 | GO:0000018 | Not Cancer Driver | No | 46 | 0.131 | 335 | 43 | 0.128 | 0 |
| RBBP8_ENST00000327155 | RBBP8 | Q99708 | DNA endonuclease RBBP8 | chr18 | GO:0000018 | Not Cancer Driver | No | 99 | 0.11 | 750 | 76 | 0.101 | 1 |
| RIF1 | RIF1 | Q5UIP0 | Telomere-associated protein RIF1 | chr2 | GO:0000018 | Not Cancer Driver | No | 287 | 0.116 | 1355 | 164 | 0.121 | 0 |
| RUVBL1 | RUVBL1 | Q9Y265 | RuvB-like 1 | chr3 | GO:0000018 | Not Cancer Driver | No | 54 | 0.118 | 67 | 7 | 0.104 | 0 |
| RUVBL2 | RUVBL2 | Q9Y230 | RuvB-like 2 | chr19 | GO:0000018 | Not Cancer Driver | No | 62 | 0.134 | 100 | 13 | 0.13 | 0 |
| SHLD1 | SHLD1 | Q8IYI0 | Shieldin complex subunit 1 | chr20 | GO:0000018 | Not Cancer Driver | No | 30 | 0.146 | 116 | 20 | 0.172 | 0 |
| SHLD2_ENST00000298784 | SHLD2 | Q86V20 | Shieldin complex subunit 2 | chr10 | GO:0000018 | Not Cancer Driver | No | 84 | 0.101 | 157 | 14 | 0.089 | 0 |
| SHLD3 | SHLD3 | Q6ZNX1 | Shieldin complex subunit 3 | chr5 | GO:0000018 | Not Cancer Driver | No | 3 | 0.012 | 81 | 1 | 0.012 | 0 |
| SLC15A4 | SLC15A4 | Q8N697 | Solute carrier family 15 member 4 | chr12 | GO:0000018 | Not Cancer Driver | No | 66 | 0.114 | 23 | 4 | 0.174 | 0 |
| SMARCAD1_ENST00000354268 | SMARCAD1 | Q9H4L7 | SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 | chr4 | GO:0000018 | Not Cancer Driver | No | 129 | 0.126 | 388 | 50 | 0.129 | 0 |
| STAT6_ENST00000543873 | STAT6 | P42226 | Signal transducer and activator of transcription 6 | chr12 | GO:0000018 | Census, Compendium | Yes | 106 | 0.125 | 325 | 44 | 0.135 | 0 |
| SUPT6H | SUPT6H | Q7KZ85 | Transcription elongation factor SPT6 | chr17 | GO:0000018 | Not Cancer Driver | No | 222 | 0.129 | 761 | 107 | 0.141 | 0 |
| TBX21 | TBX21 | Q9UL17 | T-box transcription factor TBX21 | chr17 | GO:0000018 | Not Cancer Driver | No | 70 | 0.131 | 348 | 50 | 0.144 | 0 |
| TERF2 | TERF2 | Q15554 | Telomeric repeat-binding factor 2 | chr16 | GO:0000018 | Not Cancer Driver | No | 33 | 0.061 | 361 | 20 | 0.055 | 0 |
| TERF2IP | TERF2IP | Q9NYB0 | Telomeric repeat-binding factor 2-interacting protein 1 | chr16 | GO:0000018 | Not Cancer Driver | No | 28 | 0.07 | 310 | 16 | 0.052 | 0 |
| TFRC_ENST00000392396 | TFRC | P02786 | Transferrin receptor protein 1 | chr3 | GO:0000018 | Census | Yes | 89 | 0.117 | 80 | 6 | 0.075 | 1 |
| TGFB1 | TGFB1 | P01137 | Transforming growth factor beta-1 proprotein | chr19 | GO:0000018 | Not Cancer Driver | No | 41 | 0.105 | 41 | 4 | 0.098 | 10 |
| THOC1 | THOC1 | Q96FV9 | THO complex subunit 1 | chr18 | GO:0000018 | Not Cancer Driver | No | 55 | 0.084 | 280 | 26 | 0.093 | 0 |
| TIMELESS | TIMELESS | Q9UNS1 | Protein timeless homolog | chr12 | GO:0000018 | Not Cancer Driver | No | 154 | 0.127 | 367 | 51 | 0.139 | 0 |
| TNFSF13 | TNFSF13 | O75888 | Tumor necrosis factor ligand superfamily member 13 | chr17 | GO:0000018 | Not Cancer Driver | No | 14 | 0.056 | 109 | 6 | 0.055 | 0 |
| TNFSF4 | TNFSF4 | P23510 | Tumor necrosis factor ligand superfamily member 4 | chr1 | GO:0000018 | Not Cancer Driver | No | 28 | 0.153 | 1 | 0 | 0.0 | 0 |
| TP53BP1_ENST00000263801 | TP53BP1 | Q12888 | TP53-binding protein 1 | chr15 | GO:0000018 | Not Cancer Driver | No | 227 | 0.115 | 1632 | 190 | 0.116 | 0 |
| TRRAP | TRRAP | Q9Y4A5 | Transformation/transcription domain-associated protein | chr7 | GO:0000018 | Census, Compendium | Yes | 554 | 0.144 | 402 | 59 | 0.147 | 8 |
| UBE2B | UBE2B | P63146 | Ubiquitin-conjugating enzyme E2 B | chr5 | GO:0000018 | Not Cancer Driver | No | 13 | 0.086 | 68 | 6 | 0.088 | 0 |
| VPS72 | VPS72 | Q15906 | Vacuolar protein sorting-associated protein 72 homolog | chr1 | GO:0000018 | Not Cancer Driver | No | 43 | 0.118 | 329 | 37 | 0.112 | 0 |
| WAS | WAS | P42768 | Wiskott-Aldrich syndrome protein | chrX | GO:0000018 | Census, Compendium | Yes | 75 | 0.149 | 400 | 55 | 0.138 | 30 |
| WDR48 | WDR48 | Q8TAF3 | WD repeat-containing protein 48 | chr3 | GO:0000018 | Not Cancer Driver | No | 61 | 0.09 | 125 | 19 | 0.152 | 0 |
| WRAP53 | WRAP53 | Q9BUR4 | Telomerase Cajal body protein 1 | chr17 | GO:0000018 | Not Cancer Driver | No | 66 | 0.12 | 232 | 29 | 0.125 | 4 |
| YEATS4 | YEATS4 | O95619 | YEATS domain-containing protein 4 | chr12 | GO:0000018 | Not Cancer Driver | No | 23 | 0.101 | 17 | 1 | 0.059 | 0 |
| ZCWPW1 | ZCWPW1 | Q9H0M4 | Zinc finger CW-type PWWP domain protein 1 | chr7 | GO:0000018 | Not Cancer Driver | No | 90 | 0.139 | 456 | 61 | 0.134 | 0 |
| ZSCAN4_ENST00000612521 | ZSCAN4 | Q8NAM6 | Zinc finger and SCAN domain-containing protein 4 | chr19 | GO:0000018 | Not Cancer Driver | No | 108 | 0.249 | 249 | 58 | 0.233 | 0 |