| GO term | GO name | GO namespace | GO def |
| GO:0000987 | cis-regulatory region sequence-specific DNA binding | molecular_function | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. The proximal promoter is in cis with and relatively close to the core promoter. [GOC:txnOH-2018] |
| GO:0003677 | DNA binding | molecular_function | Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). [GOC:dph, GOC:jl, GOC:tb, GOC:vw] |
| GO:0000139 | Golgi membrane | cellular_component | The lipid bilayer surrounding any of the compartments of the Golgi apparatus. [GOC:mah] |
| GO:0000978 | RNA polymerase II cis-regulatory region sequence-specific DNA binding | molecular_function | Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site) located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by RNA polymerase II. [GOC:txnOH-2018] |
| GO:0016021 | integral component of membrane | cellular_component | The component of a membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane. [GOC:dos, GOC:go_curators] |
| GO:0005789 | endoplasmic reticulum membrane | cellular_component | The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah] |
| GO:0005739 | mitochondrion | cellular_component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
| GO:0000977 | RNA polymerase II transcription regulatory region sequence-specific DNA binding | molecular_function | Binding to a specific sequence of DNA that is part of a regulatory region that controls the transcription of a gene or cistron by RNA polymerase II. [GOC:txnOH] |
| GO:0005654 | nucleoplasm | cellular_component | That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653] |
| GO:0001067 | transcription regulatory region nucleic acid binding | molecular_function | Binding to a nucleic acid region that regulates a nucleic acid-based process. Such processes include transcription, DNA replication, and DNA repair. [GOC:txnOH] |
| GO:0007283 | spermatogenesis | biological_process | The developmental process by which male germ line stem cells self renew or give rise to successive cell types resulting in the development of a spermatozoa. [GOC:jid, ISBN:9780878933846, PMID:28073824, PMID:30990821] |
| GO:0000976 | transcription cis-regulatory region binding | molecular_function | Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. [GOC:txnOH] |
| GO:0005488 | binding | molecular_function | The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule. [GOC:ceb, GOC:mah, ISBN:0198506732] |
| GO:1990837 | sequence-specific double-stranded DNA binding | molecular_function | Binding to double-stranded DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA, e.g. promotor binding or rDNA binding. [GOC:dos, GOC:sl] |
| GO:0003690 | double-stranded DNA binding | molecular_function | Binding to double-stranded DNA. [GOC:elh, GOC:vw] |
| GO:0043565 | sequence-specific DNA binding | molecular_function | Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. [GOC:jl] |
| GO:0005515 | protein binding | molecular_function | Binding to a protein. [GOC:go_curators] |
| GO:0000981 | DNA-binding transcription factor activity, RNA polymerase II-specific | molecular_function | A DNA-binding transcription factor activity that modulates the transcription of specific gene sets transcribed by RNA polymerase II. [GOC:txnOH-2018] |
| GO:0006357 | regulation of transcription by RNA polymerase II | biological_process | Any process that modulates the frequency, rate or extent of transcription mediated by RNA polymerase II. [GOC:go_curators, GOC:txnOH] |
| GO:0005783 | endoplasmic reticulum | cellular_component | The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732] |
| GO:0003676 | nucleic acid binding | molecular_function | Binding to a nucleic acid. [GOC:jl] |
| GO:0097159 | organic cyclic compound binding | molecular_function | Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure. [GOC:sjw, PMID:7583672] |
| GO:0001228 | DNA-binding transcription activator activity, RNA polymerase II-specific | molecular_function | A DNA-binding transcription factor activity that activates or increases transcription of specific gene sets transcribed by RNA polymerase II. [GOC:aruk, GOC:txnOH-2018, PMID:20737563, PMID:27145859] |
| GO:0005634 | nucleus | cellular_component | A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators] |
| GO:1901363 | heterocyclic compound binding | molecular_function | Binding to heterocyclic compound. [GOC:TermGenie] |
| GO:0030968 | endoplasmic reticulum unfolded protein response | biological_process | The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation. [GOC:mah, PMID:12042763] |
| GO:0031965 | nuclear membrane | cellular_component | Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space. [GOC:mah, GOC:pz] |
| GO:0045944 | positive regulation of transcription by RNA polymerase II | biological_process | Any process that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter. [GOC:go_curators, GOC:txnOH] |
| GO:0005794 | Golgi apparatus | cellular_component | A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732] |
| GO:0000785 | chromatin | cellular_component | The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130] |