Uniprot name=
RFPL3
Uniprot Id=
O75679
Chromosome=
chr22
Ensembl Transcript=
ENST00000249007.4
Sequence len=
317
Name=
Ret finger protein-like 3
Ret finger protein-like 3
not Cancer Driver
Labels
Structure
ROI
COSMIC iSiMPre
Features
All
Sequence
Complexity
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Complexity SEG
Complexity Dust
Complexity TRF
Exons
OMIM
Polymorphisms
PhastCons
Domains
Structure
Disorder
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Combined
Experimental
AlphaFold
RSA
IUPred
Anchor
Motifs
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ELM Instances
ELM Switches
ScanSite
ClinVar
DIBS
MFIB
Modifications
Uniprot Features
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Region of Interest
Binding regions
Conservations
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Global
Mammalia
Vertebrata
CBioportal Mutations
Toggle Dropdown
CBioportal Missense
CBioportal Indel
CBioportal Frameshift
COSMIC Mutations
Toggle Dropdown
COSMIC Missense
COSMIC Indel
COSMIC Frameshift
TCGA Mutations
Toggle Dropdown
TCGA Missense
TCGA Indel
TCGA Frameshift
TCGALegacy Mutations
Toggle Dropdown
TCGALegacy Missense
TCGALegacy Indel
TCGALegacy Frameshift
CoiledCoils
Binding domain
PhaSePro
Cancertype
All
BLCA
BRCA
CESC
COAD
ESCA
GBM
HNSC
KIRC
KIRP
LAML
LGG
LIHC
LUAD
LUSC
OAD
OT
OV
PAAD
PRAD
READ
SARC
SKCM
STAD
THCA
UCEC
Summary Table
Driver Prediction
CBioportal
COSMIC
TCGA
TCGALegacy
OMIM
ClinVar
Disorder
Driver Prediction
by 20/20 rule
CBioportal Summary Informations
26.3%
16.3%
12.5%
11.3%
5%
5%
3.75%
3.75%
3.75%
3.75%
2.5%
2.5%
1.25%
1.25%
1.25%
SKCM
LUAD
LUSC
UCEC
LIHC
HNSC
SARC
STAD
BRCA
PRAD
CESC
GBM
OV
BLCA
PAAD
Missense
plotly-logomark
33.3%
33.3%
33.3%
LUAD
LUSC
SKCM
Frameshift/Nonsense
plotly-logomark
CBioportal Indel
data not found for this gene.
CBioportal Indel
data not found for this gene.
COSMIC Summary Informations
31.1%
11.9%
9.63%
6.67%
6.67%
4.44%
3.7%
2.96%
2.22%
2.22%
2.22%
2.22%
2.22%
2.22%
1.48%
1.48%
1.48%
1.48%
1.48%
0.741%
0.741%
0.741%
OT
LUAD
SKCM
UCEC
LUSC
OAD
READ
HNSC
OV
KIRC
BRCA
STAD
LIHC
GBM
SARC
CESC
COAD
LAML
PRAD
BLCA
THCA
PAAD
Missense
plotly-logomark
75%
25%
OT
LUSC
Frameshift/Nonsense
plotly-logomark
COSMIC Indel
data not found for this gene.
COSMIC Indel
data not found for this gene.
TCGA Summary Informations
20%
13.8%
12.3%
10.8%
6.15%
4.62%
4.62%
4.62%
4.62%
3.08%
3.08%
3.08%
3.08%
3.08%
1.54%
1.54%
SKCM
LUSC
UCEC
LUAD
HNSC
OV
BRCA
STAD
READ
SARC
CESC
KIRC
LIHC
GBM
BLCA
COAD
Missense
plotly-logomark
50%
50%
LUSC
SKCM
Frameshift/Nonsense
plotly-logomark
TCGA Indel
data not found for this gene.
TCGA Indel
data not found for this gene.
TCGALegacy Summary Informations
25.9%
18.8%
10.6%
7.06%
7.06%
3.53%
3.53%
3.53%
3.53%
3.53%
3.53%
2.35%
1.18%
1.18%
1.18%
1.18%
1.18%
1.18%
UCEC
SKCM
LUSC
COAD
LUAD
SARC
CESC
BRCA
STAD
GBM
HNSC
LIHC
OV
ESCA
KIRP
LGG
READ
PRAD
Missense
plotly-logomark
25%
25%
25%
25%
ESCA
LUSC
UCEC
SKCM
Frameshift/Nonsense
plotly-logomark
TCGALegacy Indel
data not found for this gene.
TCGALegacy Indel
data not found for this gene.
OMIM Summary Informations
OMIM Disease
plotly-logomark
ClinVar Summary Informations
ClinVar Disease
plotly-logomark
Structure Summary Informations
87.7%
12.3%
87.7%
12.3%
Disorder
IUpred
Alpha.
plotly-logomark
Download
Basic
Genome
Comlexity
SNP & Disease
Structure
Disorder
TCGA
COSMIC
Motifs & PTM
Uniprot
Bindings
Phase Separation
Conservation
Sig. Mut.
0
50
100
150
200
250
300
zf-C3HC4_4
RDM
PRY
SPRY
Position
?
Sequence
?
Exons
?
PhastCons
?
Complexity-SEG
?
Complexity-DUST
?
Complexity-TRF
?
Polymorphism
?
OMIM Disease Mutations
?
ClinVar
?
CBioportal missense
?
CBioportal indel
?
CBioportal frameshift
?
COSMIC missense
?
COSMIC indel
?
COSMIC frameshift
?
TCGA missense
?
TCGA indel
?
TCGA frameshift
?
TCGALegacy missense
?
TCGALegacy indel
?
TCGALegacy frameshift
?
Domains
?
Structure
?
Combined disorder
?
Exp disorder
?
Alphafold disorder (PLDDT)
?
Alphafold disorder (RSA)
?
IUPred disorder
?
Anchor disorder
?
ELM instances
?
ELM Switches
?
ScanSite
?
PTM
?
Regions of interest
?
Binding regions
?
DIBS
?
MFIB
?
Binding domain
?
PhaSePro
?
Coiled Coils
?
Global
?
Mammalia
?
Vertebrata
?
|1
|51
|101
|151
|201
|251
|301
M
K
R
L
S
L
V
T
T
N
R
L
S
P
Q
G
N
F
L
P
L
C
T
F
P
L
A
V
D
M
A
A
L
F
Q
E
A
S
S
C
P
V
C
S
D
Y
L
E
K
P
M
S
L
E
C
G
C
T
V
C
L
K
C
I
N
S
L
Q
K
E
P
H
G
E
D
L
L
C
C
C
C
S
M
V
S
Q
R
N
K
I
R
P
N
R
Q
L
E
R
L
V
S
H
I
K
E
L
E
P
K
L
K
K
I
L
Q
M
N
P
R
M
R
K
F
Q
V
D
M
T
L
D
A
D
T
A
N
N
F
L
L
I
S
D
D
L
R
S
V
R
S
G
L
I
T
Q
N
R
Q
D
L
A
E
R
F
D
V
S
V
C
I
L
G
S
P
R
F
T
C
G
R
H
Y
W
E
V
D
V
G
T
S
T
E
W
D
L
G
V
C
R
E
S
V
H
C
K
G
K
I
Q
L
T
T
E
L
G
F
W
T
V
S
L
R
D
G
S
R
L
S
A
S
T
V
P
L
T
F
L
L
V
D
R
K
L
Q
R
V
G
I
F
L
D
M
G
M
Q
N
V
S
F
F
D
A
E
S
G
S
H
V
Y
T
F
R
S
V
S
A
E
E
P
L
R
P
F
L
A
P
S
I
P
P
N
G
D
Q
G
V
L
S
I
C
P
L
M
N
S
G
T
T
D
A
P
V
R
P
G
E
A
K
zf-C3HC4_4
HMM_Acc:
PF15227.9
HMM_Name:
zf-C3HC4_4
type:
Domain
Position:
40
-
81
select
RDM
HMM_Acc:
PF11002.11
HMM_Name:
RDM
type:
Domain
Position:
83
-
124
select
PRY
HMM_Acc:
PF13765.9
HMM_Name:
PRY
type:
Family
Position:
127
-
175
select
SPRY
HMM_Acc:
PF00622.31
HMM_Name:
SPRY
type:
Family
Position:
179
-
296
select
ErkDD
Name:
Erk D-domain
Short Name:
ErkDD
Site Sequence:
RKLQRVGiFLDMGMQ
Site:
I247
Score:
0.38
Position:
240
-
254
select
S
S
T
S
S
S
Y
T
S
AlphaFold Structure
CBioportal
COSMIC
TCGA
TCGALegacy
missense
frameshift
color
Information on Sequence
Domains and Motifs
Pfam:
ELM Instances:
ELM Switches:
PTMs
PTM from dbPTM and Phosphosite:
Uniprot Annotations
Region in interest:
Binding Site:
OMIM Disease
OMIM:
Interaction Graph
Full Interaction Table
All Interaction
Intact
Biogrid
Hippie
Interaction with Cancer Drivers
Intact
Biogrid
Hippie