Uniprot name=
CCNL2
Uniprot Id=
Q96S94
Chromosome=
chr1
Ensembl Transcript=
ENST00000400809.7
Sequence len=
520
Name=
Cyclin-L2
Cyclin-L2
not Cancer Driver
Labels
Structure
ROI
COSMIC iSiMPre
Features
All
Sequence
Complexity
Toggle Dropdown
Complexity SEG
Complexity Dust
Complexity TRF
Exons
OMIM
Polymorphisms
PhastCons
Domains
Structure
Disorder
Toggle Dropdown
Combined
Experimental
AlphaFold
RSA
IUPred
Anchor
Motifs
Toggle Dropdown
ELM Instances
ELM Switches
ScanSite
ClinVar
DIBS
MFIB
Modifications
Conservations
Toggle Dropdown
Global
Mammalia
Vertebrata
Eumetazoa
Opisthokonta
Eukaryota
Viridiplantae
Uniprot Features
Toggle Dropdown
Region of Interest
Binding regions
CoiledCoils
Binding domain
PhaSePro
CBioportal Mutations
Toggle Dropdown
CBioportal Missense
CBioportal Indel
CBioportal Frameshift
COSMIC Mutations
Toggle Dropdown
COSMIC Missense
COSMIC Indel
COSMIC Frameshift
TCGA Mutations
Toggle Dropdown
TCGA Missense
TCGA Indel
TCGA Frameshift
TCGALegacy Mutations
Toggle Dropdown
TCGALegacy Missense
TCGALegacy Indel
TCGALegacy Frameshift
Cancertype
All
BLCA
BRCA
CESC
COAD
DLBC
ESCA
GBM
HNSC
KIRC
KIRP
LAML
LGG
LIHC
LUAD
LUSC
MESO
OAD
OT
OV
PAAD
PRAD
READ
SKCM
STAD
THCA
UCEC
Summary Table
Driver Prediction
CBioportal
COSMIC
TCGA
TCGALegacy
OMIM
ClinVar
Disorder
Driver Prediction
by 20/20 rule
CBioportal Summary Informations
21.9%
12.5%
10.9%
10.9%
9.38%
9.38%
4.69%
4.69%
3.13%
3.13%
1.56%
1.56%
1.56%
1.56%
1.56%
1.56%
SKCM
HNSC
LUSC
STAD
BLCA
PRAD
UCEC
LUAD
BRCA
OV
THCA
LIHC
CESC
COAD
GBM
PAAD
Missense
plotly-logomark
27.3%
18.2%
18.2%
18.2%
18.2%
STAD
SKCM
BLCA
BRCA
UCEC
Frameshift/Nonsense
plotly-logomark
CBioportal Indel
data not found for this gene.
CBioportal Indel
data not found for this gene.
COSMIC Summary Informations
40%
12.9%
7.1%
4.52%
3.87%
3.87%
3.87%
3.23%
3.23%
2.58%
1.94%
1.94%
1.94%
1.94%
1.29%
1.29%
1.29%
1.29%
0.645%
0.645%
0.645%
OT
OAD
COAD
SKCM
LUAD
STAD
HNSC
LUSC
BRCA
BLCA
GBM
UCEC
KIRC
PRAD
THCA
PAAD
LIHC
OV
LAML
CESC
DLBC
Missense
plotly-logomark
46.2%
15.4%
15.4%
7.69%
3.85%
3.85%
3.85%
3.85%
OT
UCEC
LIHC
OAD
READ
SKCM
BLCA
STAD
Frameshift/Nonsense
plotly-logomark
66.7%
33.3%
OT
READ
Indel
plotly-logomark
66.7%
33.3%
del
ins
Indels_Ins_Del
plotly-logomark
TCGA Summary Informations
17%
11.3%
9.43%
9.43%
9.43%
7.55%
7.55%
5.66%
5.66%
3.77%
3.77%
1.89%
1.89%
1.89%
1.89%
1.89%
SKCM
HNSC
LUSC
STAD
BRCA
COAD
BLCA
UCEC
KIRC
PRAD
OV
THCA
LIHC
CESC
LUAD
GBM
Missense
plotly-logomark
42.9%
28.6%
14.3%
14.3%
UCEC
SKCM
BLCA
STAD
Frameshift/Nonsense
plotly-logomark
100%
READ
Indel
plotly-logomark
100%
del
Indels_Ins_Del
plotly-logomark
TCGALegacy Summary Informations
22.2%
10%
10%
7.78%
7.78%
5.56%
5.56%
4.44%
4.44%
3.33%
3.33%
3.33%
2.22%
2.22%
2.22%
1.11%
1.11%
1.11%
1.11%
1.11%
UCEC
SKCM
COAD
STAD
HNSC
LUSC
BLCA
GBM
CESC
KIRP
LGG
BRCA
PRAD
OV
ESCA
THCA
LIHC
LUAD
MESO
READ
Missense
plotly-logomark
23.1%
23.1%
15.4%
15.4%
15.4%
7.69%
UCEC
BRCA
SKCM
BLCA
STAD
ACC
Frameshift/Nonsense
plotly-logomark
TCGALegacy Indel
data not found for this gene.
TCGALegacy Indel
data not found for this gene.
OMIM Summary Informations
OMIM Disease
plotly-logomark
ClinVar Summary Informations
ClinVar Disease
plotly-logomark
Structure Summary Informations
57.5%
42.5%
57.5%
42.5%
Disorder
IUpred
Alpha.
plotly-logomark
Download
Basic
Genome
Comlexity
SNP & Disease
Structure
Disorder
TCGA
COSMIC
Motifs & PTM
Uniprot
Bindings
Phase Separation
Conservation
Sig. Mut.
0
100
200
300
400
500
Cyclin_N
Cyclin_C
Position
?
Sequence
?
Exons
?
PhastCons
?
Complexity-SEG
?
Complexity-DUST
?
Complexity-TRF
?
Polymorphism
?
OMIM Disease Mutations
?
ClinVar
?
CBioportal missense
?
CBioportal indel
?
CBioportal frameshift
?
COSMIC missense
?
COSMIC indel
?
COSMIC frameshift
?
TCGA missense
?
TCGA indel
?
TCGA frameshift
?
TCGALegacy missense
?
TCGALegacy indel
?
TCGALegacy frameshift
?
Domains
?
Structure
?
Combined disorder
?
Exp disorder
?
Alphafold disorder (PLDDT)
?
Alphafold disorder (RSA)
?
IUPred disorder
?
Anchor disorder
?
ELM instances
?
ELM Switches
?
ScanSite
?
PTM
?
Regions of interest
?
Binding regions
?
DIBS
?
MFIB
?
Binding domain
?
PhaSePro
?
Coiled Coils
?
Global
?
Mammalia
?
Vertebrata
?
Eumetazoa
?
Opisthokonta
?
Eukaryota
?
Viridiplantae
?
|1
|51
|101
|151
|201
|251
|301
|351
|401
|451
|501
M
A
A
A
A
A
A
A
G
A
A
G
S
A
A
P
A
A
A
A
G
A
P
G
S
G
G
A
P
S
G
S
Q
G
V
L
I
G
D
R
L
Y
S
G
V
L
I
T
L
E
N
C
L
L
P
D
D
K
L
R
F
T
P
S
M
S
S
G
L
D
T
D
T
E
T
D
L
R
V
V
G
C
E
L
I
Q
A
A
G
I
L
L
R
L
P
Q
V
A
M
A
T
G
Q
V
L
F
Q
R
F
F
Y
T
K
S
F
V
K
H
S
M
E
H
V
S
M
A
C
V
H
L
A
S
K
I
E
E
A
P
R
R
I
R
D
V
I
N
V
F
H
R
L
R
Q
L
R
D
K
K
K
P
V
P
L
L
L
D
Q
D
Y
V
N
L
K
N
Q
I
I
K
A
E
R
R
V
L
K
E
L
G
F
C
V
H
V
K
H
P
H
K
I
I
V
M
Y
L
Q
V
L
E
C
E
R
N
Q
H
L
V
Q
T
S
W
N
Y
M
N
D
S
L
R
T
D
V
F
V
R
F
Q
P
E
S
I
A
C
A
C
I
Y
L
A
A
R
T
L
E
I
P
L
P
N
R
P
H
W
F
L
L
F
G
A
T
E
E
E
I
Q
E
I
C
L
K
I
L
Q
L
Y
A
R
K
K
V
D
L
T
H
L
E
G
E
V
E
K
R
K
H
A
I
E
E
A
K
A
Q
A
R
G
L
L
P
G
G
T
Q
V
L
D
G
T
S
G
F
S
P
A
P
K
L
V
E
S
P
K
E
G
K
G
S
K
P
S
P
L
S
V
K
N
T
K
R
R
L
E
G
A
K
K
A
K
A
D
S
P
V
N
G
L
P
K
G
R
E
S
R
S
R
S
R
S
R
E
Q
S
Y
S
R
S
P
S
R
S
A
S
P
K
R
R
K
S
D
S
G
S
T
S
G
G
S
K
S
Q
S
R
S
R
S
R
S
D
S
P
P
R
Q
A
P
R
S
A
P
Y
K
G
S
E
I
R
G
S
R
K
S
K
D
C
K
Y
P
Q
K
P
H
K
S
R
S
R
S
S
S
R
S
R
S
R
S
R
E
R
A
D
N
P
G
K
Y
K
K
K
S
H
Y
Y
R
D
Q
R
R
E
R
S
R
S
Y
E
R
T
G
R
R
Y
E
R
D
H
P
G
H
S
R
H
R
R
Cyclin_N
HMM_Acc:
PF00134.26
HMM_Name:
Cyclin_N
type:
Domain
Position:
55
-
192
select
Cyclin_C
HMM_Acc:
PF02984.22
HMM_Name:
Cyclin_C
type:
Domain
Position:
195
-
308
select
MOD
ELM_Acc:
ELMI003650
Name:
MOD_DYRK1A_RPxSP_1
type:
MOD
Position:
397
-
401
select
MOD
ELM_Acc:
ELMI003651
Name:
MOD_DYRK1A_RPxSP_1
type:
MOD
Position:
424
-
428
select
CDK1_2
Name:
CDK1 motif 2 - [ST]PxxK
Short Name:
CDK1_2
Site Sequence:
LDGTSGFsPAPKLVE
Site:
S330
Score:
0.2675
Position:
323
-
337
select
Clk2_Kin
Name:
Clk2 Kinase
Short Name:
Clk2_Kin
Site Sequence:
GRESRSRsRSREQSY
Site:
S384
Score:
0.4664
Position:
377
-
391
select
PKC_common
Name:
PKC alpha/beta/gamma
Short Name:
PKC_common
Site Sequence:
RSPSRSAsPKRRKSD
Site:
S400
Score:
0.3757
Position:
393
-
407
select
GSK3b
Name:
GSK3-improved
Short Name:
GSK3b
Site Sequence:
KSQSRSRsRSDSPPR
Site:
S423
Score:
0.3725
Position:
416
-
430
select
PKC_common
Name:
PKC alpha/beta/gamma
Short Name:
PKC_common
Site Sequence:
HKSRSRSsSRSRSRS
Site:
S466
Score:
0.3609
Position:
459
-
473
select
Clk2_Kin
Name:
Clk2 Kinase
Short Name:
Clk2_Kin
Site Sequence:
RDQRRERsRSYERTG
Site:
S498
Score:
0.4694
Position:
491
-
505
select
Clk2_Kin
Name:
Clk2 Kinase
Short Name:
Clk2_Kin
Site Sequence:
ESRSRSRsREQSYSR
Site:
S386
Score:
0.4557
Position:
379
-
393
select
Cdc2_Kin
Name:
Cdc2 Kinase
Short Name:
Cdc2_Kin
Site Sequence:
RSPSRSAsPKRRKSD
Site:
S400
Score:
0.3188
Position:
393
-
407
select
Clk2_Kin
Name:
Clk2 Kinase
Short Name:
Clk2_Kin
Site Sequence:
KSQSRSRsRSDSPPR
Site:
S423
Score:
0.5216
Position:
416
-
430
select
GSK3b
Name:
GSK3-improved
Short Name:
GSK3b
Site Sequence:
KSRSRSSsRSRSRSR
Site:
S467
Score:
0.3796
Position:
460
-
474
select
Akt_Kin
Name:
Akt Kinase
Short Name:
Akt_Kin
Site Sequence:
QRRERSRsYERTGRR
Site:
S500
Score:
0.3974
Position:
493
-
507
select
Akt_Kin
Name:
Akt Kinase
Short Name:
Akt_Kin
Site Sequence:
RSRSREQsYSRSPSR
Site:
S390
Score:
0.4392
Position:
383
-
397
select
Cdk5_Kin
Name:
Cdk5 Kinase
Short Name:
Cdk5_Kin
Site Sequence:
RSPSRSAsPKRRKSD
Site:
S400
Score:
0.2138
Position:
393
-
407
select
Akt_Kin
Name:
Akt Kinase
Short Name:
Akt_Kin
Site Sequence:
QSRSRSRsDSPPRQA
Site:
S425
Score:
0.4211
Position:
418
-
432
select
Clk2_Kin
Name:
Clk2 Kinase
Short Name:
Clk2_Kin
Site Sequence:
KSRSRSSsRSRSRSR
Site:
S467
Score:
0.4136
Position:
460
-
474
select
Clk2_Kin
Name:
Clk2 Kinase
Short Name:
Clk2_Kin
Site Sequence:
QRRERSRsYERTGRR
Site:
S500
Score:
0.398
Position:
493
-
507
select
Clk2_Kin
Name:
Clk2 Kinase
Short Name:
Clk2_Kin
Site Sequence:
RSRSREQsYSRSPSR
Site:
S390
Score:
0.498
Position:
383
-
397
select
CDK1_1
Name:
CDK1 motif 1 - [ST]Px[KR]x
Short Name:
CDK1_1
Site Sequence:
RSPSRSAsPKRRKSD
Site:
S400
Score:
0.1841
Position:
393
-
407
select
Akt_Kin
Name:
Akt Kinase
Short Name:
Akt_Kin
Site Sequence:
RSRSRSDsPPRQAPR
Site:
S427
Score:
0.443
Position:
420
-
434
select
Clk2_Kin
Name:
Clk2 Kinase
Short Name:
Clk2_Kin
Site Sequence:
RSRSSSRsRSRSRER
Site:
S469
Score:
0.5203
Position:
462
-
476
select
Nek5
Name:
Nek5
Short Name:
Nek5
Site Sequence:
RSRSYERtGRRYERD
Site:
T504
Score:
0.5661
Position:
497
-
511
select
CDK1_1
Name:
CDK1 motif 1 - [ST]Px[KR]x
Short Name:
CDK1_1
Site Sequence:
REQSYSRsPSRSASP
Site:
S394
Score:
0.1708
Position:
387
-
401
select
CDK1_2
Name:
CDK1 motif 2 - [ST]PxxK
Short Name:
CDK1_2
Site Sequence:
RSPSRSAsPKRRKSD
Site:
S400
Score:
0.3262
Position:
393
-
407
select
Clk2_Kin
Name:
Clk2 Kinase
Short Name:
Clk2_Kin
Site Sequence:
RSSSRSRsRSRERAD
Site:
S471
Score:
0.3307
Position:
464
-
478
select
CDK1_2
Name:
CDK1 motif 2 - [ST]PxxK
Short Name:
CDK1_2
Site Sequence:
REQSYSRsPSRSASP
Site:
S394
Score:
0.3122
Position:
387
-
401
select
Akt_Kin
Name:
Akt Kinase
Short Name:
Akt_Kin
Site Sequence:
SSRSRSRsRERADNP
Site:
S473
Score:
0.4574
Position:
466
-
480
select
Clk2_Kin
Name:
Clk2 Kinase
Short Name:
Clk2_Kin
Site Sequence:
SSRSRSRsRERADNP
Site:
S473
Score:
0.316
Position:
466
-
480
select
A
S
S
S
S
Y
T
K
K
K
K
K
T
T
S
S
S
S
S
S
T
K
K
S
S
Y
S
S
S
S
S
T
S
S
S
S
S
S
S
S
S
S
S
S
S
S
S
S
K
Y
S
S
Y
S
Cyclin-like 1
Note: Cyclin-like 1
Evidence: None
select
Cyclin-like 2
Note: Cyclin-like 2
Evidence: None
select
RS
Note: RS
Evidence: None
select
AlphaFold Structure
CBioportal
COSMIC
TCGA
TCGALegacy
missense
frameshift
color
Information on Sequence
Domains and Motifs
Pfam:
ELM Instances:
ELM Switches:
PTMs
PTM from dbPTM and Phosphosite:
Uniprot Annotations
Region in interest:
Binding Site:
OMIM Disease
OMIM:
Interaction Graph
Full Interaction Table
All Interaction
Intact
Biogrid
Hippie
Interaction with Cancer Drivers
Intact
Biogrid
Hippie